NCI-CCC Tumor Board Question
These are questions being discussed by academics at NCI-Cancer Centers
Questions discussed in this category
I am not sure there is much efficacy for a regimen that does not include asparaginase. The patient received 2 cycles of P-GemOx, then was admitted for...
Most patients with PGNMID have no detectable disease in their marrow or blood and urine protein cannot adequately be monitored.
At the time of initial diagnosis, there was no clear CNS involvement. When it became clinically apparent disease was refractory to EPOCH, there was CS...
Would you continue R-CHOP or would you switch therapy?
Would you consider this de novo DLBCL (unable to assess for clonality)? How would you handle prior anthracycline exposure?
Is the therapeutic purpose of the proteasome inhibitor to maximize total dosage per week or number of infusions per week?
Which PI and at what dosing intervals? Dexamethasone or not?
Emory has now published data with VRd consolidation as well as KPd consolidation, while ...
240-300 mg/m2 prior exposure. How would your management change in young fit/older individuals with comorbidities? Would you obtain interval TTE during...
Do you incorporate PEG-asparaginase or brentuximab vedotin (for CD30-expressing malignant cells) into anthracycline-based induction regimens? Do you c...
How do you choose between CAR-T and autoSCT, for example?
Would you still go to auto or consider allo?
Would you intercalate HD-MTX with her CHOEP?
Does your management change if symptomatic or asymptomatic?
For pts w/ eGFR between 30-60
CAR-T (any specific preference of product?) vs bispecific antibodies vs any other specific agents not previously utilized?
Is a repeatedly abnormal serum immunofixation all it takes for MGUS?
Would you continue with daratumumab maintenance per ANDROMEDA or switch regimen?
Ki67 = 90% with multiple small nodes on PET scan and normal CBC
Patient in mid-30s with no major medical history presented with isolated left neck swelling. Incisional biopsy w/ HTLV1/2 associated ATLL, Ki67 of >...
Would you try atezolizumab/bevacizumab or switch to a TKI?
Should staging and treatment decisions be made based on imaging alone?
If so, for what platelet count threshold and do you have a preference as to which agent?
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Papers discussed in this category
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Hepatology, 2019 Oct 14
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Transplantation, 2021 Apr 27
Surgery, 2017 Jun 16
The New England journal of medicine, 2012-05-10
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Blood, 2012 Aug 13
J Clin Oncol, 2020 Apr 16
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The New England journal of medicine, 2017-04-06
The Lancet. Oncology, 2019-01
Blood,
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Blood Cancer J, 2020 Mar 09
JAMA Oncol,
Haematologica, 2021 Jun 01
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The New England journal of medicine, 2015-11-05
Haematologica, 2018 May 24
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Leukemia, 2011 Jul 01
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JAMA Oncol,
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Blood, 2018-07-05
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J Clin Oncol, 2021 Jun 25
British journal of haematology, 2017-11
J Clin Oncol, 2016 Feb 29
Lancet Haematol, 2016 Dec 05
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N Engl J Med,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-08-20
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Leukemia, 2020 Jul 21
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Lancet (London, England), 2019-01-19
N Engl J Med, 2022 Jun 03
J Hematol Oncol, 2021 Oct 30
Blood, 2022 Mar 03
Lancet,
N Engl J Med, 2021 Dec 11
Lancet Oncol, 2020 Jun 05
Lancet Oncol, 2022 Jul 12
Blood, 2022 Oct 20
J Clin Oncol, 2017 Jan 17
The Lancet. Oncology, 2011 Dec 13
American journal of hematology, 2016-09
Blood, 2017 Jun 13
JAMA, 2023 Aug 8
Blood, 2017 Jan 31
Blood, 2020 Apr 09
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Kidney international, 2018-07
BMC nephrology, 2019-02-14
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-12-10
Blood, 2015 Jun 24
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Oct 05
The New England journal of medicine, 2024 Dec 09
Blood cancer journal, 2020 Oct 16
Blood advances, 2023 Nov 14