Hematology   

Is parasitemia >10% and severe hemolysis with Hb less than 7 enough to initiate this?

At the time of count recovery or do you continue it throughout induction and consolidation?

E.g., for a patient with myeloma, s/p induction therapy, and high-dose chemotherapy, followed by autologous rescue with inappropriate antibody respons...

If so, for how long? 

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

Infection is not part of the criteria for starting treatment both in UpToDate and in NCCN guidelines. 

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

Can experts comment on fungal pneumonia risk with individual BTK inhibitors as seen in ELEVATE-RR and whether this impacts their management decisions?

Is there a role for empiric antibiotics if there is history of opportunistic infection?

Does your recommendation differ between autologous and allogeneic transplants? Does your recommendation differ in allogeneic transplant recipients wh...

Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?