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Pediatric Hematology/Oncology • Internal Medicine • Rheumatology • Hematology • Benign Hematology • General Rheumatology • Infectious Disease • Neurology • Neuro-immunology
Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?
Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?
Answer from: at Community Practice
This is an extremely important and timely question. There simply isn’t enough data or firm guidelines on this leading to different practices. The reality is that there have been a number of meningococcal breakthrough infections in those vaccinated against meningococcal disease. Complement ther...
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Answer from: at Academic Institution
In my practice, I do NOT prescribe antibiotics routinely to patients treated with eculizumab, but, that said, I understand the approach proposed by Drs. @Silversteen Silversteen and @Belmont, because the patient population I treat is different; I use it only in neuromuscular patients with refractory...
Answer from: at Academic Institution
I agree with the perspective provided by Dr. @Silversteen most especially that, although infrequent, breakthrough infections with meningococcus have occurred despite vaccination with ACWY and B vaccines. My experience with Eculizumab and Ravulizumab includes patients with SLE or SLE with CAPS and cl...