How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?   

My preference would be to use G-CSF at the lowest effective dose, i.e., the dose that maintains the ANC >1000. The risk of inducing leukemia is low in individuals with idiopathic, chronic neutropenia, but it is positively correlated with the G-CSF dose. There are also other side effects like bone...