Do you recommend lifelong antibiotic prophylaxis, or do you prefer a more selective approach based on risk factors in asplenic patients without a history of severe infections?  

The advice is limited by the fact that there are no randomized controlled trials in adults on daily antibiotic prophylaxis post-splenectomy. There are trials in children with sickle-cell disease that do show a benefit, but it is not clear that these can be extrapolated to splenectomized adults. Furt...

My habit has been to counsel the patient and provide amox-clav to be self-administered in case of any fever or rigors, etc. if he cannot see a physician promptly. Then call physician for follow up as soon as available. If the patient has one episode of true sepsis, hospitalized with invasive Haemop...