Neuro-infectious disease

Questions discussed in this category

How do you interpret CSF pleocytosis in the context of significant leukocytosis on CBC?

For example, a patient with 100 WBCs in CSF with a peripheral WBC 43k/mm3 due to AML.

1 Answer available

What are the current treatment options for progressive multifocal leukoencephalopathy in patients without HIV/AIDS?

Are there any clinical trials underway to study additional therapies?

1 Answer available

What is your preferred first-line treatment for chronic fatigue in patients with long COVID-19?

7 Answers available

Do you choose an antibiotic with CSF penetration, such as nafcillin over cefazolin, in the setting of MSSA endocarditis with septic emboli to the brain (assuming no concomitant meningitis or brain abscess)?

3 Answers available

Do you repeat a lumbar puncture in a patient living with HIV diagnosed with and treated for neurosyphilis and if so, when?

1 Answer available

How do you approach the management of EBV Meningoencephalitis (CSF pleocytosis and CSF PCR positive for EBV)?

3 Answers available

When are steroids indicated in the treatment of strep pneumo meningitis?

Does timing relative to initiation of antibiotics matter?

1 Answer available

How do you approach the diagnosis and treatment of recurrent neurosyphilis in a previously treated patient?

Are VDRL titers useful?

1 Answer available

If you have a patient with isolated CN VII palsy (Bell's Palsy), and straightforward symptoms with no red flags (such as concern for carcinomatous meningitis), do you routinely get an MRI brain or do you just make a clinical diagnosis?

2 Answers available

What is your approach to the treatment of PML-IRIS in patients with HIV who have progressed to AIDS?

1 Answer available

When would you consider checking JC virus prior to initiating biologic therapy?

1 Answer available

Papers discussed in this category

Journal of neurovirology, 2018-06

Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.

Medical sciences (Basel, Switzerland), 2018-09-21

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization.

The Journal of clinical investigation, 2021 Dec 15

The intersection of COVID-19 and autoimmunity.

Molecular systems biology, 2023 Mar 15

A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation.

BMJ open, 2024 May 13

Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia.

Lancet Infect Dis, 2004 Mar

Steroids in adults with acute bacterial meningitis: a systematic review.

Cochrane Database Syst Rev, 2015 Sep 12

Corticosteroids for acute bacterial meningitis.

Lancet Neurol, 2010 Feb 03

Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data.

Clin Neurol Neurosurg, 2021 Jan 19

Clinical significance of Epstein-Barr virus in the cerebrospinal fluid of immunocompetent patients.

BMC Infect Dis, 2011 Oct 21

Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 Nov 12

Lessons from Epstein-Barr virus DNA detection in cerebrospinal fluid as a diagnostic tool for EBV-induced central nervous system dysfunction among HIV-positive patients.

The Journal of infectious diseases, 1980 Mar

A study of cephalothin and desacetylcephalothin in cerebrospinal fluid in therapy for experimental pneumococcal meningitis.

Antimicrobial agents and chemotherapy, 1976 Sep

Pharmacological study of cefazolin during intermittent and continuous infusion: a crossover investigation in humans.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020 May 08

Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis.

Neuro-infectious disease

Questions discussed in this category

Papers discussed in this category

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