Pediatric Hematology/Oncology

General Rheumatology

Questions discussed in this category

Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?

2 Answers available

Is it necessary to prescribe a steroid taper after two weeks of high-dose prednisone (60 mg daily)?

4 Answers available

When would you consider using G-CSF in patients with rheumatic disease who have received cyclophosphamide?

2 Answers available

Is there a role for nitazoxanide for treatment of norovirus gastroenteritis in immunocompromised patients?

1 Answer available

How do you utilize cytokine panels in your clinical practice?

Is there utility when classic inflammatory markers (ESR,CRP) or disease specific markers (C3, C4, dsDNA) do not correlate with patients disease activi...

1 Answer available

What is your approach to working up diarrhea in an immunocompromised patient?

1 Answer available

Does IVIG or subcutaneous Ig interfere with monoclonal antibody therapy (i.e. dupilumab, infliximab, rituximab, etc)?

How should IVIG and either biologic injections or infusions be spaced?

2 Answers available

Is there a concern for the potential of future congenital malformations in offspring when preservation of eggs and sperm is done AFTER cyclophosphamide treatment given that it is an alkylating agent?

1 Answer available

How do you approach evaluation and management of arthralgia in a patient after CAR-T cell therapy?

1 Answer available

How do you approach dosing of anakinra in MAS?

1 Answer available

Do you typically see peripheral neuropathy in patients with castleman syndrome?

2 Answers available

Is rituximab for refractory ITP contraindicated in the setting of an active COVID infection, particularly in a patient with asymptomatic COVID?

2 Answers available

Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

3 Answers available

In patients who develop a VTE, what conditions do you consider as persistent, provoking risk factors, and at what point are they controlled enough to stop anticoagulation?

I.e., what constitutes well-controlled cancer, IBD, nephrotic syndrome, etc. What other diseases do you put in this category (obesity, autoimmune dise...

1 Answer available

Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

1 Answer available

Papers discussed in this category

Blood Adv,

American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism.

Clin Microbiol Infect, 2018 Feb 07

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).

Clinical pharmacokinetics, 2018-12

Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease.

Frontiers in immunology, 2018

Reversing Autoimmunity Combination of Rituximab and Intravenous Immunoglobulin.

Clinical immunology (Orlando, Fla.), 2020 Jul 15

The potential impact of timing of IVIG administration on the efficacy of rituximab for immune tolerance induction for patients with Pompe disease.

The Pediatric infectious disease journal, 2018 Oct

Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017 Nov 03

Successful IVIG treatment without discontinuation of TNF-α blocker in Guillain-Barre syndrome induced by adalimumab in patient with Crohn's disease.

Pediatr Blood Cancer, 2021 Oct

Idiopathic multicentric Castleman disease with TAFRO clinical subtype responsive to IL-6/JAK inhibition: A pediatric case series.

Ther Adv Musculoskelet Dis, 2020 Nov 24

Efficacy of high-dose anakinra in refractory macrophage activation syndrome in adult-onset Still's disease: when dosage matters in overcoming secondary therapy resistance.

Blood advances, 2024 Aug 13

Long-term outcomes of peripheral blood stem cell unrelated donors mobilized with filgrastim.

Annals of oncology : official journal of the European Society for Medical Oncology, 2018 Sep 01

Overall survival and risk of second malignancies with cancer chemotherapy and G-CSF support.

J Rheumatol, 2006 Jul 01

Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares.

Journal of pharmacy practice, 2021 Nov 08

Use of Colony-Stimulating Factors in Patients With Systemic Lupus Erythematosus.

The Journal of infection, 2011-11

Norovirus gastroenteritis successfully treated with nitazoxanide.

Alimentary pharmacology & therapeutics, 2006 Nov 15

Nitazoxanide in the treatment of viral gastroenteritis: a randomized double-blind placebo-controlled clinical trial.

Journal of tropical medicine, 2017 Feb 26

Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country.

Lupus, 2014 Jul 30

Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections.

MMWR. Morbidity and mortality weekly report, 2024 Sep 12

Use of 21-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024.

Journal of the Endocrine Society, 2022 Dec 02

Perioperative Evaluation and Management of Patients on Glucocorticoids.

Diagnostics (Basel, Switzerland), 2021 Apr 20

Glucocorticoid Withdrawal-An Overview on When and How to Diagnose Adrenal Insufficiency in Clinical Practice.

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