Do you consider using capecitabine and irinotecan (XELIRI) instead of FOLFIRI for first line metastatic colorectal cancer?   

There are no data to suggest that CAPIRI is more effective than FOLFIRI. However, the former is a much more toxic regimen, primarily because diarrhea is a significant, overlapping toxicity with capecitabine and irinotecan (BICC-C trial, JCO 2007). Consequently, I don't use CAPIRI.