Do you ever stop tobramycin prophylaxis in a patient with chronic bronchiectasis previously colonized with pseudomonas?  

Yes, I will often stop tobramycin if there are issues with tolerance, antibiotic resistance, or treatment fatigue. Further, in more mild bronchiectasis (cylindrical vs. varicoid or cystic morphologies), sputum bacterial cultures will negatively convert on chronic cycled inhaled tobramycin, and this ...

Agree with @Colin. In contrast to CF where chronic Pseudomonas is rarely eradicated, we do see eradication of chronic Pseudomonas in patients with bronchiectasis from other causes besides CF.  The biggest challenge to eradication for NEW Pseudomonas in individuals with bronchiectasis not from ...