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Do you recommend adjuvant chemoradiation for T2N0 gastric adenocarcinoma?
In a patient with an R0 resection, would you routinely recommend postop chemoradiation, since these patients were included in the MacDonald trial? Does the degree of lymph node dissection (D0 or D1) affect your recommendation? Does the toxicity outweigh the potential benefit?
Answer from: Radiation Oncologist at Academic Institution
In general, we do not recommend adjuvant RT for T2N0 gastric adenocarcinomas unless other adverse factors were present. The long term results of the INT-0116 trial stated patients were T3-4 or node positive, but the initial report says stages IB-IV. Notably, the studied allowed T1N1 but not T2N0. Al...
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