Do you recommend adjuvant radiation in patients with intrahepatic cholangiocarcinoma (IHCC) resected with a positive margin (R1 resection)?

If so, what dose/volume would you use? Would you cover any nodal regions electively?

Answer from: Radiation Oncologist at Academic Institution

When considering the competing risk of distant mets, the probability of isolated local failure in this disease is probably very low and treatment of the positive margin may not result in a clear benefit. Patients with intrahepatic cholangiocarcinoma have about a 70% or more distant failure rate, and...

Comments

Radiation Oncologist at X-Ray Medical Group Radiation Oncology (XRO)
Thank you Dr. @Crane. Would the presence of gross ...

Radiation Oncologist at Memorial Sloan-Kettering Cancer Center
If there's suspicion of gross residual disease, I ...

Radiation Oncologist at University of Western Ontario Schulich School of Medicine & Dentistry
If you were to offer radiation for an R1 resection...

Radiation Oncologist at Memorial Sloan-Kettering Cancer Center
It depends on if the duodenum or colon is nearby. ...

Radiation Oncologist at UAB Department of Radiation Oncology
Although agree on higher distant failure rate of t...

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Do you recommend adjuvant radiation in patients with intrahepatic cholangiocarcinoma (IHCC) resected with a positive margin (R1 resection)?

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