Please select the option that best describes you:
Topics:
Hematologic Malignancies • Internal Medicine • Hematology • Neurology • Allergy & Immunology • Neuromuscular • Neuro-immunology • MGUS
Does receiving IVIG confound the result of SPEP and/or UPEP?
Answer from: at Community Practice
IVIG being a product of polyclonal immunoglobulins may ‘produce’ a monoclonal spike if the AUC is falsely calculated by the reader. IFE usually shows polyclonal banding but every now and then a monoclonal band is picked up. Being an IgG molecule with a 21 day halflife; and with the assum...
Sign in or Register to read more
Answer from: at Community Practice
Checking for IgG antibodies while on IVIg can give false positives. Hep C antibodies, ANA, and related results are often misinterpreted when drawn on IVIg. Waiting at least 6 weeks would be the optimal.
Also, sed rates will be very elevated with IVIG. Generally, it is best to do as much of your aut...