How is pediatric and young adult primary bone lymphoma risk stratified?

NCCN guideline V4.2021 DLBCL page BCEL-3 states stage I-II, bulky >= 7.5cm should be treated with 6 cycles of RCHOP, but most bone lymphoma studies did not list tumor size as a risk factor. Does this guideline apply to primary bone lymphoma?

Answer from: at Academic Institution

I can only talk to the pediatric experience. Studies done a number of years ago showed that multiple bone lymphoma does not give a poorer prognosis and therefore in Pediatric NHL, even widespread bone is not stage IV or FAB LMB Group C. If B-lineage, it would be stage III or Group B hence 4 courses...

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at Arnold Palmer Hospital Center for Children’s Cancer and Blood Disorders
Dr. @Sheila S. Weitzman, thank you very much for y...

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How is pediatric and young adult primary bone lymphoma risk stratified?

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