How soon do you anticipate response to cyclosporine in red cell aplasia and what cyclosporine trough levels do you target?  

I typically use tacrolimus rather than cyclosporine. I find it has fewer off target effects and is easier to maintain blood levels. Trough blood level is 5-10. Cyclosporine levels are 100-400 which is too broad. I would give it at least 3 months. If not done already, I would do for LGL.