How would you treat a pediatric or AYA patient with Ph-like ALL with induction failure?  

This is a bit of a complicated discussion. There are 2 major subtypes of Ph-like ALL, 1) CRLF2-rearranged B-ALL; 2) non-CRFL2 B-ALL which is characterized by fusions in a variety of genes including ABL1, ABL2, JAK2, etc.  If you have a patient with a documented fusion in ABL1, ABL2, and others...