How would you treat a widely metastatic poorly differentiated pancreatic neuroendocrine cancer?  

The standard first line systemic therapy for poorly differentiated extrapulmonary neuroendocrine carcinoma (EP NEC) remains PE or platinum and etoposide (with some studies suggesting superiority of cis over carbo which likely reflects bias from patient characteristics). This is based on less than op...

Tumor grade matters a great deal in pancreatic neuroendocrine tumors (PNET). When you are treating poorly differentiated, as opposed to well-differentiated or even moderately-differentiated, disease -- and especially when dealing with widely metastatic/high-volume situations -- I strongly favor star...