How would you treat de novo MET amplified, RAS wt metastatic CRC after progression on standard first-line therapy?  

I personally have used tepotinib or capmatinib (completely off label) and have had excellent results (n=2) and sustained response of ~9mo in one and ~12mo in another. Again, this is completely off label and it was after a very serious discussion and goals and outcomes. Both patients are very young, ...