Is it acceptable to deliver ablative hypofractionated radiation therapy for unresectable intrahepatic cholangiocarcoma in conjunction with concurrent checkpoint inhibitor?   

There are safety data from MGH with single agent checkpoint inhibition (from @Theodore S. Hong) that demonstrate the combination is safe. The only concern I would have would be if you were starting both at the same time and the TAAs started to rise. You would not be able to discern toxicity from the...