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Radiation Oncology • Gastrointestinal Cancers • Rectal Cancer • Medical Oncology • ASCO Journal Club
Is there a correlation between rectal cancer stage and dose response to radiotherapy?
Dose-escalation RT trials have had mixed results in the past for advanced rectal cancer, while in the early rectal stage there is a tendency towards a correlation between cCR and dose.
Answer from: Radiation Oncologist at Academic Institution
Possibly. While some compelling data from Appelt et al. in 2013 reflected there may be a correlation between RT dose and rectal tumor response (Appelt et al., PMID 22763027), an extensive number of prospective trials examining the influence of boost doses of RT on pathologic response have produced m...
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