What is your approach to counseling patients regarding re-initiation of anti-TNF therapy after completion of treatment for non-disseminated pulmonary histoplasmosis?   

We published a retrospective study on this topic in 2015 (Vergidis et al., PMID 25870331). We concluded that resumption of TNF-alpha antagonist therapy may be considered in individuals treated for histoplasmosis who have no evidence of residual disease and undetectable Histoplasma antigen levels. We...

Generally with regards to Histoplasmosis, as with many other infectious diseases, treatment of the infection (either active treatment or completed treatment) is not a contraindication to re-initiation of the immunosuppressive agent. This should always be a clinical decision based on the relative ris...