What therapy would you consider for refractory pediatric HR AML with KMT2Ar to try to induce remission for transplant?  

For any case of refractory AML regardless of the cytogenetics, we turn to regimens used in the relapse setting. Nowadays common choices are based on fludarabine/cytarabine (FLA), CPX-351, and/or venetoclax. For this patient, I would focus on FLA and venetoclax-based regimens. To take advantage of th...