When administering adjuvant RT to the prostate bed with concurrent ADT, do you start concurrently or prefer to administer the ADT first?   

In the absence of evidence I turn to first principles. If the ADT were short-term and aimed towards improving local control, then I would start the ADT a good few months ahead of the radiation to maximize the synergy. However, if it was a high-risk case with ADT planned for a few years and the radia...

In general when giving post-op RT with ADT, our usual practice is to follow the paradigm of 2 mo neoadjuvant, and 2+ mo concurrent which is what we do for the intact setting (following RTOG 8610, 9202). It probably does take some time to generate a full therapeutic effect of ADT including castrate l...