Would you recommend adjuvant chemotherapy for a patient who achieved a CR after TNT for stage III rectal adenocarcinoma but underwent no initial surgery, and now has a local recurrence >12 months later with plans to undergo low-anterior resection?  

I wavered in my response to the poll, which tells me there is no clear "right" answer. The patient has had exposure to FOLFOX already, and assuming margins are negative, it is unclear if there is benefit to more chemo in this resection setting. I think you could apply the data we have for the lack o...