General Internal Medicine

General Infectious Disease

Questions discussed in this category

Do you recommend treating Candida albicans on urine culture from an indwelling catheter in a patient with septic shock?

Do you regularly recommend an immunological workup for patients with suspected immunodeficiency or defer to immunology?

Do you transition to oral antibiotics to treat uncomplicated Staphylococcus aureus bacteremia after patients have improved with intravenous antibiotic therapy?

4 Answers available

Would you ever consider oral doxycycline for treatment of either gram-negative or gram-positive uncomplicated bacteremia?

2 Answers available

Do you recommend to exchange nephrostomy tubes when a patient is diagnosed with a urinary tract infection in the absence of any overt signs of infection at the exit site?

In particular, in individuals who are know to have their urinary tract colonized with an organism, and they will periodically develop a urinary tract ...

2 Answers available

Do you prescribe linezolid to patients who are concomitantly on an SSRI?

8 Answers available

Do you routinely treat patients with neurosyphilis with IM penicillin for 1-3 weeks after completing a full treatment course of IV penicillin?

CDC Sexually Transmitted Infections Treatment Guidelines, 2021

2 Answers available

What agent and for how long would you treat a patient with asymptomatic azole-resistant C auris candiduria who is planning to undergo a urological procedure?

4 Answers available

How does trimethoprim-sulfamethoxazole's efficacy against S. pyogenes influence your empirical treatment of skin infections in regions with high resistance rates?

McCreary et al., PMID 37310038

2 Answers available

How would you manage and determine the duration of antibiotics for a patient with suspected chronic postoperative spinal implant infection, status post lumbar fusion, now presenting with loosened hardware on imaging, normal inflammatory markers, and no systemic infection symptoms?

2 Answers available

For patients with spinal hardware infections, in what circumstances do you recommend 12 weeks over 6 weeks of antimicrobial therapy?

1 Answer available

Do you routinely recommend suppressive antibiotic therapy for patients with spinal hardware infections who have undergone surgical debridement with retention of hardware?

1 Answer available

Is there any utility to trending Histoplasma serology titers to guide duration of therapy or treatment response for pulmonary histoplasmosis with negative urine antigen?

2 Answers available

Do you recommend, based on current evidence, avoiding antimotility agents in patients with non-fulminant C. difficile infection who have no evidence of ileus?

2 Answers available

What further evaluation do you pursue for patients who present with vague symptoms such as subjective fevers or intermittent night sweats, who have no pulmonary symptoms but have a positive IGRA?

1 Answer available

For how long would you treat a patient with dematiaceous fungi growing on a native heart valve discovered at the time of valve replacement?

1 Answer available

How would you treat an asymptomatic patient with a positive Blastomyces antibody, evidence of prior granulomatous lung disease on imaging, and who may require immunosuppression in the future?

1 Answer available

What specific criteria or patient conditions would make you hesitant to use fluoroquinolones early in the treatment course for managing MSSA joint infections with oral antibiotics?

For example, baseline QT prolongation, elderly age group, or underlying heart disease?

3 Answers available

Do you routinely consider FDG PET/CT imaging for workup of fever of unknown origin?

1 Answer available

How would you manage a patient with Crohn's disease on a biologic and presents with non-bloody diarrhea, normal-appearing mucosa on sigmoidoscopy but severe colitis on biopsy with a positive CMV stain?

Would you send a CMV DNA PCR in blood, and if you elect to treat with anti-CMV medication, how long would you treat and what parameters would you use,...

1 Answer available

Do you routinely recommend a lumbar puncture for patients with suspected ocular or otic syphilis in the absence of additional CNS symptoms?

3 Answers available

Do you routinely treat chronic sacral osteomyelitis when there is no plan for debridement or flap?

2 Answers available

How often do you see bony erosions in patients with Lyme arthritis?

1 Answer available

Is there a role for suppressive antibiotic therapy when it comes to chronic femoral/tibial osteomyelitis?

1 Answer available

In patients with possible Bartonella henselae infection and elevated IgG titer, what is the best way to confirm the diagnosis: tissue biopsy with Warthin-Starry staining, tissue sent for Bartonella henselae PCR, or tissue sent for culture?

1 Answer available

How would you approach treatment duration for patients with persistent candida species fungemia with a history of a prosthetic heart valve but negative TEE/CT PET and no other identifiable source of infection?

2 Answers available

Do you treat prosthetic joint infections after a two-stage revision arthroplasty with oral antibiotics for the full duration of therapy, assuming a susceptible oral option is available?

1 Answer available

What is your approach to monitoring of inflammatory markers during treatment of native vertebral osteomyelitis?

3 Answers available

Do you find HZV titers useful in diagnosing shingles sine herpete?

1 Answer available

Under what circumstances would you recommend early fecal microbiota transplantation over antibiotic treatment or bezlotoxumab in a patient with recurrent C. difficile infection?

1 Answer available

Have you used Karius to aid in the diagnosis of a non-resolving pneumonia, with negative bronchoscopy, biopsy, and other infectious work up in an immunocompetent patient?

1 Answer available

How exhaustive (especially considering cost) should an immunological workup be for patients with extensive, recurrent, or deep seated Staph aureus infections without obvious immunocompromise (e.g. cancer, diabetes, steroids) or recurrent breaks in skin integrity?

1 Answer available

What is your approach to a patient with undetectable MMR titers checked prior to or during immunosuppression and a history of MMR vaccination in childhood?

Is there a role for booster vaccination and if so, how do you approach the timing when a patient is already on a biologic for immunosuppression?

1 Answer available

Is there a role for repeat surveillance blood cultures in patients with prosthetic valve endocarditis without associated cardiac abscess after a 6 week course of antibiotic treatment without surgical intervention?

1 Answer available

Have you applied the POET trial to clinical practice?

1 Answer available

How long do you continue antibiotics after cholecystostomy tube placement for acute cholecystitis?

Since the COVID-19 pandemic, increasingly we see management of acute cholecystitis with cholecystostomy tubes as opposed to surgery, even amongst pati...

1 Answer available

For how long do you treat an early spinal hardware infection secondary to MSSA after operative washout and retention of hardware?

1 Answer available

Papers discussed in this category

Circulation, 2015 Sep 15

Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

The Annals of thoracic surgery, 2017 Feb 04

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies.

European heart journal, 2023 Oct 14

2023 ESC Guidelines for the management of endocarditis.

JAMA network open, 2022 Dec 01

Association of Linezolid With Risk of Serotonin Syndrome in Patients Receiving Antidepressants.

International journal of antimicrobial agents, 2023 Jun 08

Dose optimisation of linezolid in critically ill patients based on a population pharmacokinetic model: A two-centre prospective interventional study.

Pharmacy (Basel, Switzerland), 2023 Nov 20

The Association of Serotonin Toxicity with Combination Linezolid-Serotonergic Agent Therapy: A Systematic Review and Meta-Analysis.

International journal of antimicrobial agents, 2023 May 07

Real-world evaluation of linezolid-associated serotonin toxicity with and without concurrent serotonergic agents.

European heart journal, 2023 Oct 25

Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2023 May 11

Choosing patients over placebos: oral transitional therapy vs. IV-only therapy for bacteraemia and infective endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Jul 26

Attainment of Target Antibiotic Levels by Oral Treatment of Left-Sided Infective Endocarditis: A POET Substudy.

The Lancet. Infectious diseases, 2024 Jan 17

Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006-07-15

Do follow-up imaging examinations provide useful prognostic information in patients with spine infection?

The Lancet. Neurology, 2009-08

Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment.

The American journal of medicine, 2024 Mar 16

The Contribution of 18F FDG PET-CT for the Investigation of Fever of Unknown Origin and Inflammation of Unknown Origin.

Journal of neurosurgery. Spine, 2024 Nov 15

Upper instrumented vertebra pedicle screw loosening following adult spinal deformity surgery: incidence and outcome analysis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2018 Apr 13

Pedicle screw loosening is correlated to chronic subclinical deep implant infection: a retrospective database analysis.

Neurosurgery, 2020 Oct 15

Low-Grade Infection and Implant Failure Following Spinal Instrumentation: A Prospective Comparative Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018 Mar 19

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).

Mayo Clinic proceedings. Innovations, quality & outcomes, 2020 Nov 05

Are Antimotility Agents Safe for Use in Infections? Results From an Observational Study in Malignant Hematology Patients.

The Journal of antimicrobial chemotherapy, 1995 Oct

Diarrhoea caused by Clostridium difficile: response time for treatment with metronidazole and vancomycin.

The American journal of gastroenterology, 2021 Jun 01

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 Dec 17

State-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections.

Open forum infectious diseases, 2017

Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014 Jul 15

Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Oct 13

Antibiotic Myths for the Infectious Diseases Clinician.

Antimicrobial agents and chemotherapy, 2014 Feb 03

Factors that cause trimethoprim resistance in Streptococcus pyogenes.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013-06

Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trial.

General Internal Medicine

General Infectious Disease

Questions discussed in this category

Papers discussed in this category

Related Topics in General Internal Medicine