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How would you approach a patient with Li Fraumeni syndrome and a mucinous anal adenocarcinoma with inguinal node metastases?
Would presence of TP53 mutation weigh in on the offer of radiation? Would there be any change expected on the chemo regimen?
Answer from: Radiation Oncologist at Academic Institution
The safe dose of radiation in this setting is not known. There is not much published about it in Li Fraumeni patients. Mucinous adenocarcinoma suggests low rectal cancer as opposed to adeno of the anal canal. Either way, we would treat this like rectal cancer. At our institution we would ...
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