How would you approach patient with metastatic anaplastic thyroid cancer with NGS revealing only ARID1A mutation?  

It would be helpful to have the results of the entire NGS panel. Was ARID1A the only mutation noted on comprehensive tumor NGS? Was there any suggestion of MSI? ARID1A mutations usually result in either loss or decreased function of ARID1A which is a tumor suppressor. In-vitro and in-vivo data for P...