Hematology

Allergy & Immunology

Questions discussed in this category

What is your surveillance protocol for patients with common variable immunodeficiency receiving chronic IVIG therapy?

Is there a target IgG level to aim for? What should hematologists be aware of in monitoring these patients?

1 Answer available

Does receiving IVIG confound the result of SPEP and/or UPEP?

2 Answers available

Do you routinely consider FDG PET/CT imaging for workup of fever of unknown origin?

1 Answer available

What approaches can we take to initiate therapy and improve survival rates in patients with HLH?

2 Answers available

Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?

2 Answers available

Is it necessary to prescribe a steroid taper after two weeks of high-dose prednisone (60 mg daily)?

4 Answers available

What parasites do you screen for in your workup of HES?

1 Answer available

Do you perform genetic testing when patients have persistent hypogammaglobulinemia after rituximab therapy?

2 Answers available

Do you continue to check tryptase levels in your patients with idiopathic anaphylaxis despite normal levels >5 on repeated checks?

1 Answer available

Do you favor 24 hour urinary metabolites over random urine collection when screening for MCAS?

1 Answer available

Do you diagnose MCAS if a patient is concurrently on drugs known to cause non-specific mast cell degranulation?

1 Answer available

How do you utilize cytokine panels in your clinical practice?

Is there utility when classic inflammatory markers (ESR,CRP) or disease specific markers (C3, C4, dsDNA) do not correlate with patients disease activi...

1 Answer available

How would you work up a patient with cutaneous mastocytosis?

Is a BM biopsy a must when there is skin involvement? If tryptase level is mildly elevated but less than 20 would you recommend a BM biopsy?

1 Answer available

Do you utilize post-vaccination IgG titers to detect common variable immunodeficiency in patients who are about to start or are actively on B cell depleting therapy?

2 Answers available

How would you treat a woman with iron deficiency anemia, unresponsive to iron sulfate, and with allergic reaction to iron sucrose?

Anemia is secondary to menorrhagia. No gynecologic interventions were possible.

1 Answer available

Should testing for genetic causes of HLH be performed in all patients with MAS or secondary HLH regardless of the patient's age?

2 Answers available

What are the best labs to trend improvement in HLH?

1 Answer available

Should we recommend the COVID-19 booster vaccine to patients who had a DVT or any other complications such as hemolytic anemia or thrombocytopenia from prior vaccine doses?

2 Answers available

Do you recommend COVID vaccination in patients with antiphospholipid antibody positivity or other prothrombotic states not on anti-coagulation?

1 Answer available

How do you approach an isolated T-cell gene arrangement found in the setting of persistent hypereosinophilia?

If all work-up including peripheral flow, bone marrow biopsy, PET-CT returns negative, what additional management (if any) would be recommended?

1 Answer available

Are there any special considerations when evaluating patients with non-malignant hematologic or immunodeficiency disorders for allogeneic transplant?

Are there major differences in standard conditioning and/or GVHD prophylaxis regimens utilized? Does the non-relapse mortality different significantl...

3 Answers available

For which rituximab infusion reaction symptoms do you consider it safe to re-challenge in the office with adjusted rates and pre-medications?

1 Answer available

How do you handle hypogammaglobulinemia detected in patients prior to maintenance rituximab infusion?

2 Answers available

Papers discussed in this category

JAMA network open, 2018-11-02

Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.

The journal of allergy and clinical immunology. In practice, 2017

Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.

European journal of haematology, 2017-04

IgG4-related disease and lymphocyte-variant hypereosinophilic syndrome: A comparative case series.

J Allergy Clin Immunol Pract, 2021 Feb 03

CD3CD4 Lymphocytic Variant Hypereosinophilic Syndrome: Diagnostic Tools Revisited.

Eur J Haematol, 2020 May 18

Causes of hypereosinophilia in 100 consecutive patients.

Br J Haematol, 2019 Nov 13

Pegylated interferon alpha 2a is an effective and well-tolerated treatment option for lymphocyte-variant hypereosinophilic syndrome.

Br J Haematol, 2021 Jun 08

Treatment of lymphocyte-variant hypereosinophilic syndrome (L-HES): what to consider after confirming the elusive diagnosis.

Semin Hematol,

Epidemiology and risk factors for venous thrombosis.

Thromb Res, 2021 Jun 25

Absence of hypercoagulability after nCoV-19 vaccination: An observational pilot study.

Eur J Dermatol,

Telangiectasia macularis eruptiva perstans: a neglected type of mastocytosis with exclusively cutaneous involvement? A case series.

Pediatric blood & cancer, 2011-01

Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality.

Arthritis & rheumatology (Hoboken, N.J.), 2023 Jul 24

The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS).

The Journal of allergy and clinical immunology, 2021 Apr 20

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients.

European journal of immunology, 2022 Aug 10

Secondary rituximab-associated versus primary immunodeficiencies: The enigmatic border.

The journal of allergy and clinical immunology. In practice, 2022 Mar 26

Nontryptase Urinary and Hematologic Biomarkers of Mast Cell Expansion and Mast Cell Activation: Status 2022.

The journal of allergy and clinical immunology. In practice, 2022 Mar 25

Personalized Management Strategies in Mast Cell Disorders: ECNM-AIM User's Guide for Daily Clinical Practice.

Lupus, 2014 Jul 30

Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections.

MMWR. Morbidity and mortality weekly report, 2024 Sep 12

Use of 21-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024.

Journal of the Endocrine Society, 2022 Dec 02

Perioperative Evaluation and Management of Patients on Glucocorticoids.

Diagnostics (Basel, Switzerland), 2021 Apr 20

Glucocorticoid Withdrawal-An Overview on When and How to Diagnose Adrenal Insufficiency in Clinical Practice.

The American journal of medicine, 2024 Mar 16

The Contribution of 18F FDG PET-CT for the Investigation of Fever of Unknown Origin and Inflammation of Unknown Origin.

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