Questions discussed in this category
If further resection is possible, would you recommend adjuvant radiation?
Would you consider definitive radiation alone?
Would you recommend convent...
Specifically, headaches thought not to be related to increased ICP.
E.g., patients with small CNS mets without vasogenic edema or symptoms. Epidural disease without epidural spinal cord compression or asymptomatic low-...
If so, how long do you continue medication and when do you discontinue? Does treatment with surgical resection versus radiation alone change your mana...
Do you treat this similarly to IDH-Wildtype GBM with the STUPP regimen? Is there any role of less-intensive paradigms, such as 59.4 Gy/33 fx?
Is there a role for adjuvant chemotherapy or radiation?
If so, how long would you hold? This medication is given for migraines as q3 month infusions and some data suggest that CGRP plays a role in immune-mo...
Do you recommend adjuvant chemotherapy after radiation treatment?
With the recent publication in IJROBP showing a greater than 50% response rate, have you started integrating this into your practice?
Do you ever allow patients to receive a couple of cycles of systemic therapy first if there is high burden of disease? What is the maximum time after ...
What is the harm of waiting for another recurrence after a second GTR to delay the toxicity of radiation and chemotherapy? The patient is a woman <...
In a patient with metastatic cancer to the lumbar spine and epidural disease on CT who presents back pain and leg weakness:
Is a whole spine MRI in...
Do all patients with brain metastases get started on anticonvulsants?
Do you decide based on extent of edema, tumor size, or something else?&nb...
What workup do you typically recommend?
Is there diminished radiotherapy efficacy in tumor control after certain timeframe has passed for malignant meningiomas with no signs of recurrent dis...
For example a 1 or 2 mm brain metastasis? Would you consider waiting for these to enlarge slightly for reasons such as more certainty they are real, l...
How does this strategy change depending on the acuity or chronicity of the symptoms?
If a patient has a metastatic lesion in close proximity to one hippocampus, would you offer sparing of the contralateral hippocampus? Do your dose con...
Is your approach different than that to a primary essential tremor?
History of 4th ventricle choroid plexus papilloma s/p GTR, now with recurrent disease in the 4th ventricle and the left lateral ventricle (7 nodules i...
How does 1p/19q co-deletion and IDH mutation status influence your decision?
When do you consider observation?
Would you consider empiric SRS if biopsy/resection is not feasible?
When would you consider liquid biopsy?
What is your preferred dose/fractionation following a previous course of radiotherapy?
Assouline et al., PMID 24411632 recommend delivering 500cGy x 4 fractions = 2000cGy on days 1, 3, 8, 10. Do you follow this schedule, treat every othe...
If not, then what is your preferred treatment and would you integrate SRS into it?
Do you ever add prophylactic Keppra (levetiracetam) for glioblastoma patients without a seizure history based on data such as this study (nature.com) ...
How often are you scanning the brain and what is your trigger to treat?
If so, what percent likelihood do you quote patients for this risk with SRS, SRT and fully fractionated therapy?
Do you routinely discontinue the device or continue if they are otherwise tolerating the treatment well?
Do you require neurosurgical evaluation first? Do you require any patients to wear a neck brace?
What would be your preferred technique and dose/fractionation?
For stroke-like migraine attacks after radiation therapy (SMART syndrome), does your management of these patient's change with recurrent episodes? How...
If so, when do you consider this?
Is there any additional benefit to radiation in addition to steroids in a patient who is not a surgical candidate?
Has the recently published interim analysis of the CATNON trial altered your utilization of temozolomide?Does IDH status change your treatment approac...
Do you consider the small, but statistically significant, improvement in OS to outweigh the side effects of treatment?
Length of temozolomide course when given with adjuvant radiotherapy
What factors play into your decision whether to re-treat the brain with craniospinal radiotherapy vs irradiation of the spine only vs other measures (...
E.g. The case in question is for a patient planned for thoracic RT for LS-SCLC. Any medications that may help or just give much bigger expansions to c...
When do you favor RT? What is your preferred dose/fractionation?
How does length of time from prior chemoradiotherapy influence your management?
In a palliative setting, how long would you wait to initiate WBRT?
148092199717353209471835015031250020629212952033819591192901936918894184131865075661864218529183801825217929172971052917179149661622316370119054598156791586110671261114010146811444814272133151342112974128288374119121181011528102891316109481101682521039010381103179299101339796953773389498633
Papers discussed in this category
Stroke, 2008 Jul 17
J Neuroimaging, 2020 Feb 10
Lancet,
International journal of radiation oncology, biology, physics, 2018-03-15
J Clin Oncol, 2021 Dec 13
J Clin Oncol, 2020 Jul 24
Pract Radiat Oncol, 2022 Sep-Oct
Lancet Oncol, 2016 Sep 27
Neuro Oncol, 2021 May 05
Radiother Oncol, 2021 May 06
The New England journal of medicine, 2014-02-20
The New England journal of medicine, 2014-02-20
Neuro-oncology, 2016-09
Onco Targets Ther, 2017 Jan 18
Neuropsychologia, 2016 Aug 16
Neuroimage, 2006 Aug 10
Neuron, 2009 Jan 15
Radiother Oncol, 2022 Oct 20
Journal of neurosurgery, 2005-09
Surgical neurology, 2000-05
Cureus, 2020 Jun 11
Stereotact Funct Neurosurg, 2019 Nov 26
N Engl J Med,
Acta Oncol, 2015 Oct 23
Int J Radiat Oncol Biol Phys, 2020 Jun 13
Neuro-oncology, 2013-10
Acta Neurochir (Wien), 2019 Jan 29
J. Clin. Oncol., 2020 Feb 14
Cancer, 2020 May 19
N Engl J Med,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-09-01
Lancet Oncol, 2021 May 14
Strahlenther Onkol,
J Clin Oncol, 2012 Oct 15
International journal of radiation oncology, biology, physics, 2018-06-01
Surgical neurology international, 2018
J Neurooncol, 2019 Oct 01
Progress in neurological surgery, 2013
Neurosurgery,
Journal of neurosurgery. Spine, 2010-09
Spine, 2010-10-15
Neurosurgery,
Cancer, 2011 Feb 01
JAMA, 2017-12-19
Cancer, 2012-02-15
Neurosurgery, 2010-11
Neurosurgery, 2008-01
Neurosurgery, 2009-01
J Neurooncol, 2013 Nov
Neurosurgery, 2016-07
World neurosurgery, 2016-07
Strahlenther Onkol, 2017 Jun 15
World Neurosurg, 2016-03-01
J. Neurosurg., 2016-12-01
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017-12
Neurosurgery, 2018-06-01
Journal of radiosurgery and SBRT, 2013
Int. J. Radiat. Oncol. Biol. Phys., 2019 Nov 29
J Natl Compr Canc Netw, 2020 Nov 2
Radiat Oncol, 2021 Feb 17
Neuro Oncol,
J Neurosurg,
World Neurosurg, 2017 Mar 12
World Neurosurg,
The New England journal of medicine, 2018-08-23
Lancet Oncol, 2020 Apr 03
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-03-01
Sci Rep, 2020 Jul 01
Neuro Oncol,
N Engl J Med,
The Laryngoscope, 2016-01
Journal of the neurological sciences, 2011-09-15
Journal of neuro-oncology, 2012-01
The New England journal of medicine, 2005-03-10
Cancer, 1982 Feb 01
Journal of neurosurgery, 2018-01
Journal of neurosurgery, 2013-04
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-05-01
Cochrane Database Syst Rev, 2020 Apr 28
J. Neurol. Sci., 2008-12-15
J Clin Oncol, 2003 Jul 01
Int J Radiat Biol, 2018 Apr 27
Aesthet Surg J, 2010 May-Jun
Turk Gogus Kalp Damar Cerrahisi Derg, 2018 Sep 16
Journal of neuro-oncology, 2022 Aug 04
Frontiers in oncology, 2020 Jul 28
Oncology letters, 2019 Nov 19
Annals of translational medicine, 2021 Dec
The spine journal : official journal of the North American Spine Society, 2017-10
Adv Radiat Oncol, 2021 May-Jun
The New England journal of medicine, 2016-04-07
Current opinion in oncology, 2009-07
Cancer, 2012-05-01
Advances in radiation oncology, 2022 Dec 24
N Engl J Med, 2023 Jun 04
Neuroepidemiology, 2011 Jun 16
Journal of neurosurgical sciences, 2019 Jun
Fitoterapia, 2012 Oct 23
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-04-20
Neurosurgical review, 2021 Oct 20
Neurosurgery, 2002-07
Practical radiation oncology, 2013
Radiother Oncol, 2016 Nov 16
Springerplus, 2016 Jan 12
Acta neuropathologica, 2019 Dec 04
Neuro-oncology advances, 2021 Apr 19
Journal of the Endocrine Society, 2022 Dec 02
Diagnostics (Basel, Switzerland), 2021 Apr 20
Int J Radiat Oncol Biol Phys, 2006 Dec 1
Int J Radiat Oncol Biol Phys, 2019 Oct 10
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2021 May 05
International journal of radiation oncology, biology, physics, 2013-03-01
International journal of radiation oncology, biology, physics, 2020 Jan 24
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2001 Mar
Cancer research and treatment, 2006 Dec 31