What adjustments, if any, do you make to chemotherapy regimens for patients with chromosomal breakage disorders who develop malignancy?  

Patients with known DNA repair disorders (such as Ataxia-Telangiectasia, Nijmegen Breakage Syndrome) are at high risk of developing toxicity from standard chemotherapy approaches for the treatment of their leukemia/lymphoma, which is the most common malignancy they are predisposed to. Agata Pas...