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Medical Oncology

Prostate Cancer   

Questions discussed in this category

What duration androgen deprivation do you recommend with salvage pelvic radiotherapy for pelvic node relapse after prostatectomy?
8 Answers available
Do you offer RT both to the prostate and synchronous oligometastases in de novo oligometastatic prostate cancer?
If a patient presents with de novo oligometastatic (i.e., meeting STAMPEDE low met burden criteria) prostate cancer with no prior history of primary t...
5 Answers available
How do you reconcile discordant PSMA and MRI findings in patients undergoing definitive radiotherapy for prostate cancer?
For example, if MRI revealed prostate-confined disease but PSMA had moderate avidity in the bilateral seminal vesicles, would you obtain further biops...
3 Answers available
Which patients with prostate cancer do you consider to be good candidates for salvage local treatment after radiation therapy?
How does time since radiation, original PSA and grade group/gleason score inform your decision? 
2 Answers available
How would you approach de novo metastatic castrate sensitive prostate cancer with extensive locoregional spread causing rectal compression, retroperitoneal lymphadenopathy, and PSA >3000 but no visceral or bone metastases?
Would you consider adding docetaxel to ADT and novel hormonal agents?
4 Answers available
What are your top takeaways in GU Cancers from ESMO 2024?
4 Answers available
For a patient post-prostatectomy with a high PSA (>1), a negative MRI pelvis, and a negative PSMA PET scan, do you pursue any other imaging?
FDG PET, Axumin PET, Bone scan? Or just proceed with salvage ADT/RT?
4 Answers available
Are there any contraindications to Pluvicto therapy you personally use, given that there are none directly provided by the manufacturer?
2 Answers available
With multiple PARPi + ARSI combinations now approved, how are you selecting which combination to use for a patient with BRCA mutated mCRPC?
3 Answers available
Is there adequate evidence for the use of PARPi in combination with ARSI for BRCA+/HRR mutated mCRPC as compared to sequential therapy?
3 Answers available
When and how are you incorporating tumor sequencing to plan treatment of metastatic prostate cancer?
Given the FDA approvals for PARP inhibitors and combinations in mCRPC, when do you obtain NGS for mCRPC? Do you have a preferred assay?
5 Answers available
Under what circumstances would you treat prostate cancer without a biopsy?
Would you be willing to treat an elderly patient on blood thinners who has PSMA+ PET, elevated PSA, and multiple urologists have deemed biopsy too ris...
2 Answers available
In what situations would a standard FDG PET/CT be useful in the evaluation of high risk prostate cancer?
With the advent of PSMA PET/CT, this is my study of choice for high risk prostate cancer. Are there scenarios where standard FDG PET is useful? For ex...
4 Answers available
When do you start ADT for a patient with a new diagnosis of node positive prostate cancer receiving radiation?
Do you start neoadjuvantly? Concurrently?
2 Answers available
What data support the use of continuing GnRH therapy "backbone" in metastatic castration resistant prostate cancer (mCRPC) receiving additional therapies?
Long-term ADT is deleterious to multiple organ systems (bone/sexual/psychiatric) and increases the risk of MACE. What level 1 evidence do we have to c...
2 Answers available
Why are patients getting enzalutamide s/p prostatectomy not candidates for salvage radiation therapy?
On the EMBARK trial (Freedland et al., PMID 37851874), 25% of men had a prostatectomy and the publication states, "Patients were excluded … if ...
2 Answers available
What is your experience with Pylarify vs. Posluma PSMA PET for prostate cancer and is one preferred over the other?
1 Answer available
Has the recent presentation of RADICALS-HD changed your ADT duration recommendations for patients receiving post operative radiation therapy for prostate cancer after radical prostatectomy?
2 Answers available
Given RADICALS-HD, are you completing 24 mo vs 6 mo of ADT with XRT following RP?
RADICALS-HD trial (ESMO 2022) demonstrated metastasis free survival benefit with 24 months compared to 6 months of ADT.
1 Answer available
Do you offer prostate RT to men with 0-3 bone metastases on conventional imaging when PSMA PET shows a very high number of M1 lesions?
STAMPEDE answer is yes, intuitively it seems there must be a line somewhere though. For patients staged only with PET that is widely M1, should a CT ...
4 Answers available
Are you comfortable combining relugolix with enzalutamide or abiraterone?
Current NCCN guidelines recommended not combining relugolix with these agents until more data is available.  Any drug interaction concerns or ot...
2 Answers available
How would you sequence PARPi vs pembrolizumab for a patient who has progressed on ARPI to mCRPC that has somatic PALB2 mutation and MSI-H?
2 Answers available
How do you treat metastatic large cell neuroendocrine carcinoma of prostate with undetectable PSA, who had the treatment related transformation while on ADT monotherapy?
Would you treat similar to small cell carcinoma? What is the suggested chemotherapy regimen? Will you continue ADT?
1 Answer available
Would you use olaparib after progression on an ARPI for a patient with somatic PALB2 mutated mCRPC?
Given the limited # of patients with PALB2 mutation on the PROfound trial (de Bono et al., PMID 32343890) and the benefit primarily driven by Cohort A...
1 Answer available
Is there any way to safely treat patients with mCRPC with 177-Lu PSMA who are on hemodialysis?
2 Answers available
Can you give Pluvicto with concurrent palliative EBRT?
If so, do you modify your external beam dose? 
1 Answer available
Do you use denosumab for castration-sensitive prostate cancer with osseous metastases?
Only the mCRPC population was included in the Fizazi et al. study, but the FDA approval is for prevention of skeletal related events from any solid tu...
4 Answers available
What is the optimal sequence of available therapies in patients with BRCA+/HRR mCRPC after progression on first line combinations?
If a patient has already received ADT+ARSI would you use PARPi over chemotherapy in 2nd line?
2 Answers available
Will prior novel hormonal therapy affect when/how you use olaparib plus abiraterone for patients with BRCA-mutated metastatic castration resistant prostate cancer?
2 Answers available
Do you still order mpMRI for staging of prostate cancer in addition to PET-PSMA?
Which patients specifically benefit from both mpMRI and PET-PSMA?
4 Answers available
For patients who progress to mCRPC on ADT+ARSI started in mCSPC setting, do you continue the ARSI if patients have had a mixed response?
ARSI may be controlling a hormone sensitive clone. Some patients flare after stopping the drug.  
1 Answer available
Would you extrapolate from EMBARK to use an ARPI other than enzalutamide in high risk biochemically recurrent prostate cancer for a patient with contraindications to enzalutamide?
1 Answer available
Does the presence of ductal adenocarcinoma change how you risk stratify or treat patients with localized prostate cancer?
How would it change your risk group or management? Does Decipher help further inform treatment?
1 Answer available
Are there any scenarios in which you would consider use of PARPi in the upfront mCSPC setting rather than reserving for CRPC?
3 Answers available
Does a negative staging PSMA PET in a patient with biopsy-proven recurrent prostatic adenocarcinoma change your management?
I have a pair of patients with MRI+ and biopsy+ disease who have staging PSMA PET/CT that do not show disease within the prostate (or anywhere else).&...
2 Answers available
How do you manage de novo high volume mCSPC with both BRCA2 mutation and MSI-H on somatic testing?
When (if ever) would you consider immune checkpoint inhibitor up front? Would you be less inclined to offer triple drug therapy? (Some thought that ta...
1 Answer available
How do you manage hot flashes in men with prostate cancer on androgen deprivation therapy?
16 Answers available
Can you/do you use an androgen receptor blocker alone in patients with metastatic hormone-sensitive prostate cancer who cannot tolerate GnRH-directed therapy?
7 Answers available
How would you manage a patient with mCRPC with a good clinical and >50% reduction in PSA to Lu-PSMA but evidence of radiographic progression on PSMA PET/CT?
1 Answer available
How would you treat a patient presenting with de novo metastatic prostate cancer and baseline low testosterone?
If baseline testosterone is at castrate levels (e.g. <50), would you consider patient to have castrate-resistant disease?
1 Answer available
How would you treat margin positive, node positive (pN+) prostate cancer with detectable post-op PSA but negative PSMA-PET after radical perineal prostatectomy?
How does margin positive influence your decision? 
1 Answer available
How do you manage dry eye related to Pluvicto Lu-177?
2 Answers available
How do you sequence Ra-223 and Lu-177 in patients with mCRPC with predominantly bony disease?
Do you preferentially use Ra-223 first given the RALU study? 
1 Answer available
Is there a role for radiotherapy to the primary in high volume metastatic prostate cancer with well controlled disease on ADT?
1 Answer available
How do you manage drug-drug interactions between oral anticoagulants and the ARSI agents such as apalutamide and enzalutamide?
1 Answer available
How do you reconcile discrepancies in clinical prostate cancer staging with AJCC and NCCN?
In particular, in the modern era of multi-parametric prostate MRI and PSMA-PET, certain findings such as EPE, SVI, or pelvic lymphadenopathy may be no...
7 Answers available
For what duration should abiraterone be used in a patient with biochemical and pelvic node recurrence (N1M0) who had prior definitive therapy with either RP or RT?
Do you feel comfortable stopped abiraterone after 2 years? 
2 Answers available
What is the minimum duration to be on bicalutamide prior to starting GnRH agonist in de novo metastatic prostate cancer with significant bone disease?
1 Answer available
Has use of PSMA PETCT revealed increased local failures than previously known after definitive prostate EBRT with biochemical failure?
3 Answers available
How do you treat localized prostate cancer with neuroendocrine differentiation?
4 Answers available
Do you always obtain PSMA PET as initial staging for high risk and very high risk localized prostate cancer patients?
6 Answers available
Would you consider adding abiraterone to ADT and salvage RT in a prostate cancer patient with pN1 disease at radical prostatectomy?
24 months ADT + abiraterone + definitive RT is indicated for cN1 disease but not for pN1 disease per NCCN. Can the data be extrapolated to this popula...
1 Answer available
In a patient with very high risk prostate cancer opting for prostatectomy, when, if ever, do you recommend neoadjuvant ADT?
4 Answers available
How aggressive would you be in irradiating asymptomatic bone metastases in a patient with metastatic prostate cancer?
Notably, the patient presented with renal failure due to ureteral obstruction and hydronephrosis, receives hemodialysis, and has limited systemic opti...
4 Answers available
What is the optimal duration of ADT for unfavorable intermediate risk or high risk localized prostate cancer treated with SBRT instead of conventionally fractionated or hypofractionated RT?
Do you also give neoadjuvant, concurrent, and adjuvant ADT in the same manner as for non-SBRT EBRT?
5 Answers available
How do you interpret PSMA/PET with focal prostate activity after XRT currently on ADT with stable PSA?
Pretreatment PSA 25.3 with Gleason 4+3=7 and MRI suspicious for ECE. Eight months after pelvic nodal and prostate XRT to 79 Gy, PSA is 5.02 (down from...
1 Answer available
Would you treat the prostate in a patient with widely metastatic disease who has CR to all metastatic sites after systemic therapy or ADT?
2 Answers available
Do you recommend prostate RT for patients with metastatic (M1) disease?
A recent NCBD analysis (Rusthoven et al., PMID 27325855) suggests that the addition of prostate RT significantly improves survival compared to AD...
8 Answers available
Would you consider adding abiraterone, in addition to ADT, for patients with less than very-high risk localized prostate cancer but high clinical-genomic metastasis risk after EBRT?
Specifically if metastatic risk estimate approached the failure rate in control arm of STAMPEDE for high-risk non-metastatic disease (69% MFS at 6 yea...
1 Answer available
Do you ever initiate on degarelix and then switch to leuprolide for patients with prostate cancer and cardiac risk factors receiving ADT?
If so, how long are they on degarelix before the switch? 
2 Answers available
What is your approach to systemic treatment of de novo metastatic hormone-sensitive prostate ductal adenocarcinoma with lung only metastases?
1 Answer available
What systemic therapy do you recommend for prostate cancer pelvic nodal recurrence on PSMA PET-CT after prostatectomy and salvage radiation?
If ADT +/- ARPI + RT, what duration of systemic therapy do you recommend?
1 Answer available
Do you continue ADT/Lupron in all patients with castrate resistance prostate cancer?
Are there exceptions?
1 Answer available
How do you approach imaging in patients with M0 castration-resistant prostate cancer with rising PSA on an ARSI?
What imaging modality do you use (conventional, PSMA PET, etc.)? When do you image (ex: a PSA threshold or PSADT)?
1 Answer available
How do you approach a patient with prostate cancer with sclerotic/lytic lesions found on a CT scan but not seen on a bone scan or PET-PSMA?
Would you consider these as metastatic sites? Would you biopsy to confirm?
3 Answers available
Would you change AR signaling inhibitor in a patient with high volume metastatic castration-sensitive prostate cancer who started darolutamide with initial plan for docetaxel but in whom chemotherapy was eventually deferred?
Would you switch to enzalutamide or apalutamide if not giving docetaxel given darolutamide data for mCSPC is only from ARASENS trial with docetaxel?
1 Answer available
Does recent COVID-19 infection result in elevated PSA?
1 Answer available
Would you prescribe ADT or AR inhibitors for a patient with moderate to severe dementia who has biochemical recurrent, non-metastatic prostate cancer, but otherwise good physical performance status and prognosis >5 years?
Would you prescribe ADT for a patient with dementia who has biochemical recurrent, non-metastatic prostate cancer, but otherwise good physical PS?
2 Answers available
How do you approach systemic therapy for metastatic prostate cancer in geriatric patient when progressed to mCRPC on ADT alone?
2 Answers available
Would you use abiraterone or docetaxel in addition to ADT and radiotherapy for patients with very high risk, node-negative prostate cancer?
2 Answers available
Did the approval of lutetium Lu 177 vipivotide tetraxetan (Pluvicto) change how you image and manage patients with metastatic castrate-resistant prostate cancer?
When do you order PSMA PET? Do you preferably order Locametz (gallium Ga 68 gozetotide) PET? 
1 Answer available
Which imaging modality do you prefer when monitoring disease status for patients with prostate cancer undergoing 177-Lu PSMA treatment?
PSMA PET vs Conventional imaging vs combined imaging?
4 Answers available
How do you manage surveillance imaging for patients with metastatic castration-naive prostate cancer with an initial low PSA?
2 Answers available
How long after initiating ADT/androgen blockade is it acceptable to start docetaxel in a patient with high burden, de-novo metastatic HSPC where you are recommending triplet therapy?
1 Answer available
Would you consider bone antiresorptive therapy in mCRPC with only 1 lesion per PSMA scan?
1 Answer available
How do you define bone disease progression in mCRPC while on docetaxel?
Do you wait for radiographic progression? What is your preferred imaging modality for re-staging?
1 Answer available
In a patient with otherwise low-risk prostate cancer, does presence of a small component of Grade Group 3 disease up-stage to unfavorable intermediate?
How would you treat such a patient? 
3 Answers available
Is there any role for ascertaining somatostatin-receptor status with a DOTATATE PET scan in prostatic adenocarcinoma with neuroendocrine features to consider lanreotide along with chemotherapy?
1 Answer available
What clinical and pathological features do you consider when deciding which androgen receptor targeted agent to combine with ADT for a patient with newly diagnosed castrate sensitive metastatic prostate cancer?
2 Answers available
How would you approach second line treatment for prostate adenocarcinoma with diffuse neuroendocrine features?
What would you use after platinum/taxane/IO first line therapy?
1 Answer available
For a patient with localized high risk prostate cancer with high risk Decipher score receiving ADT and abiraterone, is there any value of continuing ADT and abiraterone beyond two years?
2 Answers available
Would you consider SBRT for node negative small cell carcinoma of the prostate?
2 Answers available
What duration of ADT + abiraterone do you recommend prior to initiation of HDR brachytherapy followed by EBRT for very high risk localized cT3bN0 prostate cancer?
1 Answer available
How do you approach rising PSA many years after prostatectomy with negative PSMA PET?
4 Answers available
For a patient with PSMA+ mCRPC but relatively low SUV values, does that influence your decision to use 177Lu-PSMA or discussion with patient regarding potential benefit?
Would you use an FDG PET to further inform decision?
1 Answer available
How would you manage a patient with PSA relapse 10 years after salvage radiotherapy with PSA doubling time<6 months?
Would you treat with ADT if no metastatic disease? Does absolute PSA (e.g. PSA<2) inform decision?
1 Answer available
Do you hold ADT prior to biopsy of possible prostate cancer metastatic disease?
Does ADT affect the results of a biopsy?
1 Answer available
How would you work up a patient with prostate cancer with bone scan suspicious for metastatic disease and a negative PSMA PET/CT?
Additional imaging of the potential lesions, biopsy or assume negative given normal PSMA PET/CT. 
7 Answers available
In patients who initially received chemo-hormonal first-line therapy for metastatic prostate cancer followed by abiraterone/enzalutamide for castration-resistant disease, would you re-challenge with docetaxel?
Or would you proceed with cabazitaxel or other therapy? Initial chemo-hormonal therapy was ADT + Docetaxel x6 cycles.Docetaxel rechallenge at time of ...
2 Answers available
Will you offer olaparib + abiraterone for all patients with metastatic castrate resistant prostate cancer based on results of PROPEL trial?
Do you find the ibPFS endpoint sufficient to change practice for any or all patients, or will you await OS or other data/trials?
2 Answers available
For unfavorable intermediate prostate cancer in elderly patients, would you consider radiation without ADT?
2 Answers available
What is the role of liquid biopsy in patients with metastatic castration resistant prostate cancer to asses BRCA1/2 or other mutations and consider PARP inhibitors?
Alternatively, is a biopsy of a metastatic bone lesion preferred in a patient who has already progressed on chemo and hormonal therapy and has bone-on...
2 Answers available
Given several PARP inhibitors approved or with emerging positive data in castrate resistant prostate cancer, how do you decide which one and when to use?
How do you differentiate between olaparib, rucaparib, niraparib, talazoparib?
2 Answers available
For a patient treated with abiraterone for first line metastatic prostate cancer, would you still use a combination of abiraterone/olaparib at a subsequent progression?
If yes, would you directly add olaparib at progression on abiraterone vs waiting to use abi/olaparib at a later line of therapy?
2 Answers available
Among non-HRRm castrate resistant prostate cancer patients, are there features predictive of response to PROPEL regimen of abiraterone/olaparib?
3 Answers available
What could explain the discordant results between PARP/abiraterone combinations in MAGNITUDE and PROpel in non-HRRm prostate cancer?
Is the benefit in PROpel driven by BRCA1/2 or ATM mutated tumors vs all comers?
1 Answer available
How would you treat node positive (pN+) prostate cancer with undetectable post-op PSA after radical prostatectomy and pelvic LND?
Would you offer adjuvant radiation? (Dose? Target?) vs Salvage? Would you add ADT? Would you add abiraterone? Would the number of lymph nodes involv...
3 Answers available
For HRRm prostate cancer, will you use olaparib alone or in combination with abiraterone?
1 Answer available
When would you use PARP inhibitors in patients with refractory metastatic castrate resistant prostate cancer with somatic non-BRCA HRD mutations?
Would you consider using them in patients with CHEK2 mutations?
3 Answers available
What is your general approach to treatment sequencing of available regimens in castration-resistant metastatic prostate cancer?
Do you have a preferred way to incorporate advanced androgen blockade vs chemo vs sip-T vs Lu-PSMA vs PARP vs other targeted agents?
1 Answer available
Would you treat a patient with metastatic castration resistant prostate cancer and prior treatment with Ra-223 with Lu-117-PSMA-617 therapy?
Is prior Ra-223 a contraindication for treatment? 
1 Answer available
What can prostate patients do for sexual function while on ADT?
4 Answers available
Would you ever recommend testosterone replacement for men with incomplete T recovery after ADT for prostate cancer?
Patient has ED unresponsive to cialis/viagra; would you recommend testosterone replacement therapy?
5 Answers available
How does urinary obstruction impact your choice of therapy for metastatic or locally advanced prostate cancer?
1 Answer available
In high or very high risk prostate cancer, do you utilize combined androgen blockade in patients receiving definitive RT?
Do you have a preference for bicalutamide? Can abiraterone be used instead?  
6 Answers available
At what PSA level would you consider restaging a patient who was treated with ADT and radiation and had undetectable PSA?
At what PSA would you become suspicious for biochemical recurrence and pursue restaging? Is there a threshold value? What imaging modality would you ...
2 Answers available
When would you use PSMA PET over conventional imaging for prostate cancer?
Would you use it for initial staging or at time of biochemical recurrence?
2 Answers available
Do you treat de novo metastatic hormone sensitive prostate cancer presenting with a paraneoplastic syndrome more aggressively?
1 Answer available
Do you consider estrogen patches in treatment of prostate cancer?
2 Answers available
Can abiraterone or enzalutamide be substituted for bicalutamide to prevent a flare when initiating ADT with a GnRH agonist for metastatic prostate cancer?
1 Answer available
Would you give ADT + docetaxel -> darolutamide for a low risk castrate sensitive metastatic prostate cancer patient given ARASENS results?
The trial inclusion criteria was essentially "docetaxel candidate per the treating oncologist"
2 Answers available
Would you consider de-escalating abiraterone in a patient treated with ADT/abiraterone/prednisone for metastatic hormone sensitive prostate cancer who has had an excellent response with undetectable PSA and minimal side effects for over 2 years?
Is there a concern regarding rarer side effect emergence (cardiac, bone, muscle, cognitive) of long term exposure to "maximal" androgen deprivation? I...
2 Answers available
Based on the STAMPEDE trial pooled analysis, which patients with high risk prostate cancer would you add abiraterone for 2 years?
3 Answers available
How do PSMA PET positive nodes change your treatment recommendations after RP?
Would you consider boosting the nodes?  What dose?  Would this change your recommendation for length of ADT?  
2 Answers available
How would you treat a patient with prostate cancer with de novo bone and bone marrow metastases with cytopenias?
Would you consider chemotherapy, androgen blockade or triple therapy (chemo and AR targeting)?
1 Answer available
What are your top takeaways from ASCO GU 2022?
6 Answers available
Would you consider addition of docetaxel to abiraterone and ADT in metastatic hormone senstive prostate cancer patients who progress on ADT and abiraterone?
Would the results of PEACE-1 trial justify this?
2 Answers available
Would you change treatment in a patient with metastatic CRPC on PARP inhibitor with rising PSA but negative Axumin PET scan?
2 Answers available
Do you consider ADT intensification with enzalutamide or abiraterone in patients receiving adjuvant radiation with ADT?
Are there clinical features (post-op PSA, Decipher score, pN+, pT3, etc) that would inform your decision?
2 Answers available
Do you hold ADT before work up for prostate cancer when ordering advanced imaging such as PSMA PET?
Do you worry about false negatives on PET, CT, MRI if ADT is started before the scan? Scheduling scans can sometimes book 2-4 weeks out. 
2 Answers available
For metastatic prostate cancer, when would you add carboplatin to docetaxel or cabazitaxel?
1 Answer available
What is your preferred therapy for CDK12-altered advanced prostate cancer, outside clinical trial?
Would you treat with PARP inhibitor or Check-Point Inhibitor?
1 Answer available
Do you recommend ADT or other systemic therapy in patients with rising PSA after prostatectomy and salvage RT and PSMA scan negative for metastatic disease?
2 Answers available
How would you treat a patient with Gleason 8 or 9 prostate cancer, pretreatment PSA 15-24, with retroperitoneal adenopathy?
Is there a role of EBRT to the prostate with extended fields to cover the retroperitoneal nodes plus ADT (definitive therapy) or would you treat as ca...
4 Answers available
How would you manage asymptomatic radiographic progression from M0 CRPC to M1 CRPC to bone?
PSA rose from 25 to 30 ng/mL over 6 months on darolutamide for M0 CRPC, prompting scans which showed oligometastatic disease to bone, not amenable to ...
1 Answer available
Would you consider PARP inhibition in a patient with metastatic prostate cancer and a germline BRCA2 variant of unknown significance?
Or would you restrict such treatment to patients with known pathogenic germline BRCA mutations?
1 Answer available
In addition to ADT, how would you treat Gleason 8, pure ductal prostate adenocarcinoma with oligometastatic disease?
Given ductal histology, is docetaxel preferred over NHT?
1 Answer available
Is there an absolute PSA level above which you would not recommend a radical prostatectomy for newly diagnosed prostate cancer despite the absence of metastatic disease with advanced imaging?
Are there other high or very high risk features that would also contribute to your decision making?
1 Answer available
Would you recommend surgery or radiation for newly diagnosed localized prostate cancer diagnosed on a urethral lesion biopsy?
GS 4+4. PSA low (1-2). CT and bone scan negative for lymphadenopathy or metastatic disease.  Prostate MRI pending. 
2 Answers available
Will you consider adding an AR targeted agent to ADT for a patient thought to have isolated pelvic nodal recurrence of prostate CA if next generation imaging reveals additional non-regional disease not seen on conventional imaging?
Patient previously had prostatectomy and salvage RT
1 Answer available
Would you continue or switch therapy for someone who progressed through AR directed therapy and has a rapid rise in PSA while receiving Ra-223 for bone-dominant castrate resistant prostate cancer?
1 Answer available
What is the best approach to organ confined squamous cell cancer of the prostate?
Would you recommend surgery first or neoadjuvant therapy such as concurrent cisplatin/RT or another regimen?
1 Answer available
Which patients with mCRPC on ADT + advanced anti-AR do you treat with bisphosphonates or denosumab?
Did you change your practice given the SRE results in the control arm of EORTC 1333 at ASCO 2021? When using bisphosphonates or denosumab, what dosin...
2 Answers available
How exactly would you utilize ADT via leuprolide or bicalutamide with salvage RT post prostatectomy with PSA >0.5?
2 Answers available
How and when are you using sipuleucel-T in metastatic prostate cancer given the increase in available treatment options?
Do prior treatments for mHSPC change your thinking on whether or not to use sipuleucel-T?
2 Answers available
What is your preferred choice and timing of systemic therapy in a patient with high risk oligometastatic prostate cancer undergoing metastasis directed therapy to all sites of disease, including the prostate?
1 Answer available
How would you treat high risk prostate adenocarcinoma who relapsed after RT and ADT with a very low PSA, widespread mets to bone and soft tissue who is progressing on ADT, docetaxel and carboplatin?
No targetable mutations detected
1 Answer available
How would you treat a patient with newly diagnosed prostate cancer with low volume bone metastases and extensive lung metastases with a very low PSA (< 5) and no neuroendocrine differentiation on pathology?
In addition to ADT, would you treat with abiraterone, enzalutamide or docetaxel? Or other treatment - platinum/taxane?
3 Answers available
How would you sequence 177LU-PSMA-617 with current therapies for men with mCRPC?
2 Answers available
Would you consider radical prostatectomy for a young male with unfavorable intermediate risk cT3a prostate cancer and PSMA PET concerning for regional lymph nodes involvement but negative conventional imaging?
Gleason 4+3=7 and PSA 4
3 Answers available
What are your treatment recommendations in a patient with de novo metastatic prostate adenocarcinoma with neuroendocrine differentiation?
1 Answer available
Do you consider tertiary grade pattern, LVI or PNI on prostatectomy specimens as adverse features to recommend EBRT and ADT for patients with unfavorable intermediate prostate CA after prostatectomy with undetectable PSA?
Are there other adverse features aside from seminal vesicle invasion, positive margins, or extraprostatic extension that you consider?
1 Answer available
After completing 6 cycles of docetaxel plus ADT for metastatic hormone-sensitive prostate cancer per CHAARTED, are there clinical scenarios in which you would add an additional AR targeted agent (ex: enzalutamide, abiraterone, or apalutamide) to ADT?
Does post docetaxel PSA influence your decision?
1 Answer available
For persistent PSA elevation after prostatectomy, would you recommend salvage radiation if pathologically negative nodes, but regional and non-regional lymphadenopathy on PSMA PET?
Specifically, would you offer salvage radiation to a patient who underwent a prostatectomy with PLND and had a post-op PSA of 12 with pathology reveal...
2 Answers available
How would you sequence therapies for a patient with chemotherapy-naive metastatic castration-resistant prostate cancer who is MSI-H on tissue-based NGS?
What line would you give pembrolizumab?
1 Answer available
Would you consider adding abiraterone or docetaxel in patients with high risk prostate cancer whose PSA does not become undetectable after ADT and radiotherapy with castrate level testosterone?
4 Answers available
When using active surveillance for rising PSA after prostatectomy, at what level of PSA would you start ADT?
2 Answers available
Are there any clinical scenarios where you would recommend adjuvant docetaxel for localized prostate cancer?
1 Answer available
What duration of ADT do you recommend for a patient with locally treated prostate cancer who undergoes metastasis-directed radiation therapy to a single oligometastatic bone lesion?
Would you add abiraterone or enzalutamide?
5 Answers available
In a patient with metastatic prostate cancer on abiraterone planning to start Radium-223, what is the minimum interval between the last dose of abiraterone and the first dose of Radium?
1 Answer available
What is your preferred treatment approach for a patient who has prostate cancer with disease only in retroperitoneal nodes, experiencing rapid biochemical progression on abiraterone, and who was previously treated with an androgen receptor inhibitor while non-metastatic?
1 Answer available
How would you manage a patient with localized prostate cancer treated with radical prostatectomy and found to have a single involved pelvic lymph node on final pathology and a detectable postoperative PSA?
2 Answers available
In what settings is Fluciclovine (Axumin) PET/CT best utilized in prostate cancer?
What clinical scenario(s) do you find results to be the most beneficial?
1 Answer available
Would you treat a patient with refractory, metastatic castrate resistant prostate cancer who has somatic ATM mutation with a PARP inhibitor?
Does the specimen (blood vs tissue) used to detect mutation affect your consideration?
1 Answer available
For patients with high-risk metastatic castration-sensitive prostate cancer who have completed upfront ADT + docetaxel, would you consider starting abiraterone or enzalutamide in addition to ADT while the disease is still castration-sensitive?
Are there particular populations in whom you would add an AR targeted agent after docetaxel?
6 Answers available
Which of the androgen blocking agents have the best CNS penetration for someone with metastatic CRPC with brain metastases?
Assuming patient received appropriate local therapy for brain metastases, which agent would you use?
1 Answer available
Which patients would you treat with relugolix instead of injectable GnRH agonist therapy?
HERO study - https://clinicaltrials.gov/ct2/show/NCT03085095
1 Answer available
What is your treatment approach for metastatic squamous carcinoma of the prostate?
1 Answer available
How do you decide between abiraterone or docetaxel for first line treatment of newly diagnosed metastatic prostate cancer?
Given that ADT + abiraterone and ADT + docetaxel have not been directly compared.
2 Answers available
Would you introduce AR targeted therapy if a patient has already been successfully treated with LHRH for low risk, low volume metastatic hormone sensitive prostate cancer?
What is the time window in which you would consider adding AR targeted therapy? Is there a time frame in which you would NOT consider introducing sin...
2 Answers available
Would you treat prostate cancer with hormone sensitive metastatic recurrence (after local treatment) the same as de novo metastatic hormone sensitive disease?
1 Answer available
Do you offer adjuvant chemotherapy or abiraterone for patients with high and very high risk prostate cancer with still detectable PSA after radical prostatectomy and lymph node dissection?
2 Answers available
Would you retreat a patient with docetaxel for metastatic castrate resistant prostate cancer if treated in hormone sensitive setting (metastatic disease) with good response three years ago but now has CRPC and has progressed on abiraterone?
2 Answers available
What is the preferred steroid regimen for metastatic prostate cancer patients on docetaxel?
Is there an optimal strategy to minimize unnecesary steroid use?For example, pre-treatment dexamethasone or 3 day dexamethasone? Prednisone only conti...
1 Answer available
Would you give abiraterone in the post-prostatectomy setting to patients with positive nodes detected at surgery?
Is there data and FDA approval for this indication? What about for nodal failure after radiation? 
1 Answer available
Would you treat a patient with Radium 223 for prostate cancer with mainly bone metastasis if he has a history of osteonecrosis of the jaw bone from bisphosphonate/Denosumab?
1 Answer available
How do you think about management options in a patient with a minute focus of Gleason grade 4 (4+4) on 1 core from needle biopsy along with only Gleason 3+3 disease in other biopsy cores and PSA<10?
Assuming patient is not a surgical candidate and wishes to pursue definitive radiotherapy, what duration of ADT would you give?
1 Answer available
How would you treat a patient with metastatic small cell of the prostate who is progressing on cisplatin/etoposide and has previous NGS without actionable mutations?
2 Answers available
Would you treat unfavorable intermediate risk prostate cancer in the setting of recently resected NSCLC?
How would a much higher risk cancer affect decision making? How would you treat him? 
3 Answers available
Is there a role of definitive radiation or prostatectomy, in a patient who has M0 castrate resistant prostate cancer and whose PSA is undetectable on ADT and enzulatamide?
2 Answers available
What is your approach to imaging for localization of biochemical relapse of prostate cancer after radical prostatectomy?
Abstract 5014 at ASCO annual meeting 2019 showed superiority of PSMA-PET imaging over fluciclovine-PET imaging.  Are you utilizing these speciali...
1 Answer available
For recurrent prostate cancer after definitive radiation, how do you guide patients between the various salvage options vs ADT?
1 Answer available
How does your management change for patients with bone marrow failure due to a metastatic solid tumor to the marrow?
Do you offer EPO and TPO support? Do you modify your systemic therapy up front or after subsequent cycles?
1 Answer available
In a patient with M0CRPC with PSA doubling time < 6 months, will you wait until the absolute PSA value is >2, or is PSADT alone sufficient to start an AR targeted agent?
In the SPARTAN trial, median PSA at study entry was ~ 7. Does the MFS benefit extend to patients with low PSA(< 2 or < 1)?
3 Answers available
What is the optimal duration of ADT for cN1 disease with EBRT?
3 Answers available
Would you offer PA nodal XRT in a patient with rising PSA and multiple PET positive nodes after previous prostate XRT treatment that is otherwise locally controlled?
For instance, if the fluclicovine scan shows a few small avid nodes not only in the pelvis but extending to the paraaortic region, would you treat the...
2 Answers available
What duration of ADT do you recommend for patients with high risk or very high risk prostate cancer who undergo radical prostatectomy, adjuvant RT, and adjuvant docetaxel?
1 Answer available
For a very high risk prostate cancer with relatively no elevation in PSA but no distant or nodal metastasis would you consider “neoadjuvant” ADT and chemotherapy prior to EBRT?
In this case, Gleason 5+5 in all cores, clinical T4.
1 Answer available
In a patient with intermediate risk castration sensitive prostate cancer S/P prostectomy and now with biochemical recurrence + regional lymph node involvement 8 months post RP, would you do hormonal therapy (ADT or ADT+Abiraterone) with or without EBRT?
1 Answer available
Should enzalutamide be given concurrently with Sip-T in castration-resistant metastatic prostate cancer?
2 Answers available
How do you manage androgen deprivation in a patient with oligometastatic prostate cancer in which the primary and all known metastatic sites have been treated with curative intent radiation and PSA remains undetectable?
How long would you continue androgen deprivation after radiation? 
2 Answers available
Are the cardiac risks of LHRH agonists also seen in patients undergoing bilateral orchiectomy for ADT in hormone-sensitive prostate cancer?
1 Answer available
Has the role of radium-223 changed in the treatment of prostate cancer given the availability of newer anti-androgen medications to treat metastatic prostate cancer?
2 Answers available
How much emphasis do you place on anti-AR therapy in a patient with metastatic castration resistant prostate adenocarcinoma with progressive neuroendocrine differentiation?
In a patient with a prior response to ADT and progression on taxane and platinum chemotherapy, would you consider AR directed therapy?
1 Answer available
Would you recommend Radium-223 for extensive bone disease in a prostate cancer patient with adenopathy >3cm?
Per the ALSYMPCA study, they excluded patients with > 3cm lymphadenopathy. Patient is currently on enzalutamide and leuprolide and refuses docetaxe...
1 Answer available
Is there a role for docetaxel for men with high risk prostate cancer receiving radiation and androgen deprivation therapy?
Does the STAMPEDE trial, showing a survival benefit with the addition of docetaxel to standard treatment, change the standard of care for high risk, n...
4 Answers available
How many cycles of docetaxel do you give to patients with metastatic castration resistant prostate cancer?
1 Answer available
For a patient with metastatic castration-resistant prostate cancer to the bones with rising PSA but no evidence of radiographic or symptomatic progression, would you continue with the same treatment or change therapy based on biochemical progression?
Assuming there was an initial period of response to the mCRPC treatment.
1 Answer available
Would you add atezolizumab to carboplatin + etoposide for small cell/neuroendocrine prostate cancer?
Treatment for small cell/neuroendocrine prostate is extrapolated from data on small cell lung cancer. It now appears that Carboplatin + Etoposide + At...
1 Answer available
How do you manage surveillance imaging for patients with metastatic castration-resistant prostate cancer?
Are you directed by symptoms, PSA changes or do you have a standard schedule regardless of those factors?
1 Answer available
How do you treat newly diagnosed low volume metastatic hormone sensitive prostate cancer in light of new data from STAMPEDE presented at ESMO 2018?
Abstract LBA5_PR ‘Radiotherapy (RT) to the primary tumour for men with newly-diagnosed metastatic prostate cancer (PCA): survival results from S...
1 Answer available
In view of possible equivalent efficacy of low dose abiraterone with food, has anyone had clinical experience offering low dose abiraterone to spare patients from financial toxicity of abiraterone?
Prospective International Randomized Phase II Study of Low-Dose Abiteraterone with Food versus Standard Dose Abiraterone In Castration-Resistant Prost...
1 Answer available
Is it acceptable defer or forgo biopsy and to start androgen deprivation therapy in an elderly, fragile patient with PSA in the 900s and evidence of bone metastases?
1 Answer available
When is the best time to start denosumab in men with metastatic prostate cancer?
Should it be started at the initial diagnosis of bone mets?
2 Answers available
How do you approach non-metastatic castration-resistant prostate cancer?
For which patients would you consider addition of apalutamide or enzalutamide? How do you decide between the 2 drugs?
2 Answers available
How would you approach a patient with M0 castrate-resistant prostate cancer started on enzalutamide who continues to have increasing PSA levels without metastases seen on imaging?
NCCN recommends to change therapy or maintain current therapy in this setting without further clarification. What thresholds would cause a change in t...
1 Answer available
How do you manage a patient with metastatic prostate cancer who does not acheive a PSA response to upfront ADT?
1 Answer available
How do you approach a patient with a non-castrate testosterone level and rising PSA despite receiving LHRH agonist therapy?
1 Answer available
Would you use AR-V7 testing to decide second-line androgen receptor-axis-targeted therapy vs chemotherapy for patients who with metastatic castration-resistant prostate cancer?
If yes, what factors push you to test for AR-V7 or would you test all patients in this clinical scenario?
3 Answers available
What approach would you take for patients with metastatic castration-resistant prostate cancer with marked PSA response (undetectable) on docetaxel, but radiographic progression in bone metastases?
1 Answer available
How would you treat a patient with high-volume metastatic prostate cancer who has asymptomatic biochemical relapse after having a good response to upfront docetaxel?
Would you initiate abiraterone or enzalutamide for the rising PSA or wait until the patient is symptomatic or has a new site of metastasis?
1 Answer available
How do you manage musculoskeletal pain in men receiving androgen deprivation therapy for non-metastatic prostate cancer?
In patients with new bone pain and without any evidence of bone metastases receiving GnRH agonists, how do you manage pain symptoms?
1 Answer available
If a patient with non-metastatic prostate cancer is found to have a BRCA mutation, should this influence treatment recommendations for local therapy?
2 Answers available
How do you approach isolated recurrence in a para-aortic lymph node following definitive radiation for localized prostate cancer?
Is there a role for salvage LN dissection or salvage RT to the node? And is there a role for systemic therapy (ADT or chemotherapy) in addition? If yo...
1 Answer available
Do you counsel patients on the risk of dementia following androgen deprivation therapy for prostate cancer?
Two retrospective studies from Stanford showed that patients who received ADT had an increased risk of dementia and Alzheimer's. Is this finding ...
3 Answers available
When do you initiate androgen deprivation therapy for biochemical relapse of prostate cancer following primary therapy?
Do you use a PSA threshold, PSA doubling time, or only evidence of metastatic disease to trigger ADT? For those without rapid doubling time, do you ev...
1 Answer available
What duration of androgen deprivation therapy do you use for patients with pN+ prostate cancer undergoing upfront adjuvant RT after a radical prostatectomy and pelvic lymph node dissection?
Do other factors (i.e. Gleason score, pretreatment PSA, or pT stage) affect your decision? 
2 Answers available
In light of CHAARTED and STAMPEDE, should all men with newly-diagnosed, treatment-naive metastatic prostate cancer be treated with chemohormonal therapy?
1 Answer available
Which, if any, aspects of your management of prostate cancer differ in your African-American patients versus those of other racial/ethnic backgrounds?
Given recent advancements in the understanding of biological differences in prostate cancer patients of African vs. other ancestry, does your manageme...
1 Answer available
For patients eligible for and considering active surveillance for low-risk prostate cancer, do you routinely use tests for molecular risk stratification?
Are there specific subsets for whom these results should change management?
1 Answer available
Do you routinely offer AR-v7 testing to determine whether to treat with chemotherapy versus enzalutamide or abiraterone in metastatic castration resistant prostate cancer?
2 Answers available
Do you routinely include sipuleucel-T as one of your lines of systemic therapy for metastatic castration resistant prostate cancer?
If so, how do you sequence this with other therapies?  In addition, in the absence of an effect on radiographic PFS or serum PSA, how do you asse...
1 Answer available
Which PET imaging modality, if any, is preferred to work up possible nodal involvement or local recurrence in prostate cancer?
In situations where there is a significant risk of either local or nodal persistence/recurrence post prostatectomy with a rising PSA, or nodal involve...
1 Answer available
For castration-naive metastatic prostate cancer patients who you plan to treat with LHRH agonist monotherapy, how long do you treat with an anti-androgen therapy prior to and after initiating the LHRH-agonist?
A recent systematic review suggested that disease progression owing to a testosterone "flare" may not be a real phenomenon: http://www.ncbi.nlm.nih.go...
1 Answer available
Is there a role for adjuvant docetaxel in patients with high-risk localized prostate cancer who elect for prostatectomy?
The role of adjuvant docetaxel with ADT following RT for high risk disease has been previously elucidated by RTOG 0521.  Following prostatectomy,...
1 Answer available
Following presentation of the PRINCE at ASCO 2016, should we be offering intermittent docetaxel to patients with metastatic castration-resistant prostate cancer?
At the ASCO 2016 annual meeting, results of the PRINCE trial were reported. A strategy of intermittent docetaxel was found to be non-inferior to conti...
1 Answer available
When should intermittent androgen deprivation vs continuous androgen deprivation be used for the treatment of prostate cancer?
 In a patient with node positive disease, treated definitively with radiation, should continuous or intermittent ADT be administered? If a patien...
1 Answer available
Is there any role for radium-223 early in the course of castration-resistant prostate cancer with bone metastases?
Typically radium-223 is reserved for men with symptomatic bone disease after failure of multiple other therapies.  Is there a population of men w...
1 Answer available
Should bone-directed agents, such as denosumab or zoledronic acid, be given when patients are being treated with radium-223?
1 Answer available
At what point would Radium-223 dicholoride treatment be the best management for a patient with established metastatic prostate cancer with an elevated PSA and symptomatic bone pain with corresponding bone lesions on imaging?
1 Answer available
When should SBRT be offered to oligometastatic bone disease in a patient with prostate cancer?
What factors should be considered with offering SBRT to oligometastatic bone disease in prostate cancer patients? Should this been done off of a proto...
2 Answers available


Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-04-10
Randomized controlled trial of early zoledronic acid in men with castration-sensitive prostate cancer and bone metastases: results of CALGB 90202 (alliance).
Lancet, 2016 Mar 19
Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.
Eur. Urol.,
Combining enzalutamide with abiraterone, prednisone, and androgen deprivation therapy in the STAMPEDE trial.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2015-09-01
A Randomized Phase II Trial of Sipuleucel-T with Concurrent versus Sequential Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer.
Eur Urol, 2015 Jul 16
Progression-free Survival Following Stereotactic Body Radiotherapy for Oligometastatic Prostate Cancer Treatment-naive Recurrence: A Multi-institutional Analysis.
BJU Int, 2009 Feb
Systemic therapy for advancing or metastatic prostate cancer (STAMPEDE): a multi-arm, multistage randomized controlled trial.
European urology, 2014-06
Might men diagnosed with metastatic prostate cancer benefit from definitive treatment of the primary tumor? A SEER-based study.
The New England journal of medicine, 2013-07-18
Alpha emitter radium-223 and survival in metastatic prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-05-10
Effect of Chemotherapy With Docetaxel With Androgen Suppression and Radiotherapy for Localized High-Risk Prostate Cancer: The Randomized Phase III NRG Oncology RTOG 0521 Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-01-20
Evaluating Intermittent Androgen-Deprivation Therapy Phase III Clinical Trials: The Devil Is in the Details.
The New England journal of medicine, 2004-10-07
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer.
JAMA oncology, 2016-11-01
Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer.
J. Nucl. Med., 2015 Jun 25
Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-04-01
Phase III randomized placebo-controlled trial of two doses of megestrol acetate as treatment for menopausal symptoms in women with breast cancer: Southwest Oncology Group Study 9626.
Lancet Oncol., 2010-02-01
Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: a double-blind, randomised trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-03-20
Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7.
The Journal of urology, 2005-08
Parenteral medroxyprogesterone for the management of luteinizing hormone releasing hormone induced hot flashes in men with advanced prostate cancer.
Mol Clin Oncol, 2015 May 04
Bee pollen and honey for the alleviation of hot flushes and other menopausal symptoms in breast cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-12-10
Multicenter, randomized, cross-over clinical trial of venlafaxine versus gabapentin for the management of hot flashes in breast cancer survivors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-11-10
Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer.
The Journal of urology, 1999-07
Pilot evaluation of venlafaxine for the treatment of hot flashes in men undergoing androgen ablation therapy for prostate cancer.
Annals of oncology : official journal of the European Society for Medical Oncology, 2009-03
A phase III randomized, double-blind, placebo-controlled trial of gabapentin in the management of hot flashes in men (N00CB).
Mayo Clin Proc, 2004 Oct
Pilot evaluation of paroxetine for treating hot flashes in men.
JNCI Cancer Spectr, 2019 Oct 21
Oxybutynin vs Placebo for Hot Flashes in Women With or Without Breast Cancer: A Randomized, Double-Blind Clinical Trial (ACCRU SC-1603).
N Engl J Med, 1994 Aug 11
Megestrol acetate for the prevention of hot flashes.
The New England journal of medicine, 2018-05-03
Oxybutynin for Hot Flashes Due to Androgen Deprivation in Men.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002-08-01
Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-06-20
Persistent, biologically meaningful prostate cancer after 1 year of androgen ablation and docetaxel treatment.
The Journal of urology, 2002-09
Impact of previous local treatment for prostate cancer on subsequent metastatic disease.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2009-01-15
Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence.
Nature, 2005-12-08
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.
J Clin Oncol, 1999 Jul
Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer: A randomized study.
Lancet, 2015 Jan 3
Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial.
The New England journal of medicine, 2001-12-06
Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer.
Lancet, 2001-09-22
Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial.
Breast Cancer Res. Treat., 2010-02-01
Impact of breast surgery on survival in patients with distant metastases at initial presentation: a systematic review of the literature.
The Journal of urology, 1982-06
Treatment of a metastatic prostate derived tumor with surgery and chemotherapy.
Cancer research, 2000-04-15
Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
J. Clin. Oncol., 2009-04-01
Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer.
Oncol. Rep., 2015-12-01
Surgical cytoreduction of the primary tumor reduces metastatic progression in a mouse model of prostate cancer.
Nat Commun, 2015-04-01
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.
PLoS ONE, 2016-01-01
Does Radiotherapy for the Primary Tumor Benefit Prostate Cancer Patients with Distant Metastasis at Initial Diagnosis?
J. Urol., 2002-04-01
Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis.
Lancet Oncol., 2015 Sep 09
Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial.
European urology, 2018-02
Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.
Lancet, 2018 Oct 18
Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.
The Lancet. Oncology, 2006-06
Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-06-20
Course and Predictors of Cognitive Function in Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Controlled Comparison.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-02-20
Androgen Deprivation Therapy and Future Alzheimer's Disease Risk.
JAMA oncology, 2016-04
Adverse Health Events Following Intermittent and Continuous Androgen Deprivation in Patients With Metastatic Prostate Cancer.
JAMA oncology, 2017-01-01
Association Between Androgen Deprivation Therapy and Risk of Dementia.
JCO Precision Oncology, 2017 May 31
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making
The New England journal of medicine, 2016-08-04
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
NEJM Evidence, 2022 Jun 3
Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer
The New England journal of medicine, 2018-04-12
Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer.
The New England journal of medicine, 2018-06-28
Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer.
The New England journal of medicine, 2015-08-20
Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-06-10
External Validation of the Benefit of Adjuvant Radiotherapy for Pathologic N1M0 Prostate Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-12-10
Impact of adjuvant radiotherapy on survival of patients with node-positive prostate cancer.
JAMA Oncol,
Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial.
J Urol,
Long-term followup of a randomized study of locally advanced prostate cancer treated with combined orchiectomy and external radiotherapy versus radiotherapy alone.
Urology, 2013-06
Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-T in the Immunotherapy for Prostate Adenocarcinoma Treatment (IMPACT) trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-08-20
Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162).
N. Engl. J. Med., 2019 Jun 02
Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer.
Nat Rev Urol, 2014 Apr
Small cell carcinoma of the prostate.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2013-07-01
Platinum-based chemotherapy for variant castrate-resistant prostate cancer.
N Engl J Med, 2010 Jul 29
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
N. Engl. J. Med., 2017-07-27
Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-04-10
Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2016-03-15
Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers.
Prostate Int,
Correlation and diagnostic performance of the prostate-specific antigen level with the diagnosis, aggressiveness, and bone metastasis of prostate cancer in clinical practice.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-05-10
Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-05-10
Low-Fat Abiraterone Food Effect Is of Little Consequence.
Nat Rev Urol, 2017 Dec 12
HSD3B1 status as a biomarker of androgen deprivation resistance and implications for prostate cancer.
Lancet, 2021 Dec 23
Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol.
The New England journal of medicine, 2017-07-27
Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer.
Ann. Oncol.,
Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial.
The Lancet. Oncology, 2013-08
Docetaxel and atrasentan versus docetaxel and placebo for men with advanced castration-resistant prostate cancer (SWOG S0421): a randomised phase 3 trial.
Eur Urol, 2017 Oct 23
Anticancer Activity and Tolerance of Treatments Received Beyond Progression in Men Treated Upfront with Androgen Deprivation Therapy With or Without Docetaxel for Metastatic Castration-naïve Prostate Cancer in the GETUG-AFU 15 Phase 3 Trial.
J Clin Oncol, 2017 Jul 28
Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial-FIRSTANA.
N. Engl. J. Med., 2019 May 31
Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer.
J. Clin. Oncol., 2019 Jul 22
ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer.
Lancet Oncol, 2019 Apr 12
Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial.
AJR. American journal of roentgenology, 2019-10
Fluorine-18-Labeled Fluciclovine PET/CT in Clinical Practice: Factors Affecting the Rate of Detection of Recurrent Prostate Cancer.
JAMA oncology, 2019-06-01
Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer: A Prospective Single-Arm Clinical Trial.
Clin Nucl Med,
A Prospective Head-to-Head Comparison of 18F-Fluciclovine With 68Ga-PSMA-11 in Biochemical Recurrence of Prostate Cancer in PET/CT.
The Lancet. Oncology, 2019-03
Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial.
JAMA Oncol,
Effect of Adding Docetaxel to Androgen-Deprivation Therapy in Patients With High-Risk Prostate Cancer With Rising Prostate-Specific Antigen Levels After Primary Local Therapy: A Randomized Clinical Trial.
European urology, 2018-08
Clinical and Genomic Characterization of Low-Prostate-specific Antigen, High-grade Prostate Cancer.
N. Engl. J. Med., 2019 Sep 30
Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer.
Lancet,
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
Eur. Urol., 2018 Jul 03
Duration of Androgen Deprivation Therapy in High-risk Prostate Cancer: A Randomized Phase III Trial.
Lancet, 2019 Apr 11
Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial.
J. Clin. Oncol., 2017 Dec 14
Surveillance or Metastasis-Directed Therapy for Oligometastatic Prostate Cancer Recurrence: A Prospective, Randomized, Multicenter Phase II Trial.
Eur. Urol., 2019 Jul 19
Metastasis-directed Therapy in Treating Nodal Oligorecurrent Prostate Cancer: A Multi-institutional Analysis Comparing the Outcome and Toxicity of Stereotactic Body Radiotherapy and Elective Nodal Radiotherapy.
Lancet, 2008 Dec 16
Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.
Lancet, 2011-12-17
Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.
J Thorac Oncol. , 2019 Oct 17
Nivolumab Monotherapy and Nivolumab Plus Ipilimumab in Recurrent Small Cell Lung Cancer: Results From the CheckMate 032 Randomized Cohort.
Cancer, 2020 Feb 19
Validation of a subclassification for high-risk prostate cancer in a prospective cohort.
Clin Genitourin Cancer, 2019 Mar 13
Use of Radium-223 Dichloride in Patients With Osteonecrosis of the Jaw Induced by Zoledronic Acid: Report of 2 Cases.
N. Engl. J. Med., 2020 May 29
Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2012-12-15
Cabazitaxel: more than a new taxane for metastatic castrate-resistant prostate cancer?
,
Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports.
BMC Cancer, 2014 Sep 15
Surveillance or metastasis-directed Therapy for OligoMetastatic Prostate cancer recurrence (STOMP): study protocol for a randomized phase II trial.
JAMA Oncol,
Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial.
Eur Urol, 2019 Feb 28
Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005-02-01
Androgen suppression plus radiation versus radiation alone for patients with stage D1/pathologic node-positive adenocarcinoma of the prostate: updated results based on national prospective randomized trial Radiation Therapy Oncology Group 85-31.
Urology, 2001-08
Addition of radiation therapy to androgen ablation improves outcome for subclinically node-positive prostate cancer.
The New England journal of medicine, 2017-02-02
Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer.
Lancet Oncol., 2016-06-01
Salvage radiotherapy with or without short-term hormone therapy for rising prostate-specific antigen concentration after radical prostatectomy (GETUG-AFU 16): a randomised, multicentre, open-label phase 3 trial.
JAMA Oncol, 2020 Mar 26
Association of Presalvage Radiotherapy PSA Levels After Prostatectomy With Outcomes of Long-term Antiandrogen Therapy in Men With Prostate Cancer.
Lancet, 2020 Sep 28
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A Comparison of F-DCFPyL, F-NaF, and F-FDG PET/CT in a Prospective Cohort of Men with Metastatic Prostate Cancer.
Lancet (London, England), 2020 Mar 22
Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021 May 14
PSMA-PET for the assessment of metastatic hormone-sensitive prostate cancer volume of disease.
European urology oncology, 2020 Jun 24
The Automated Bone Scan Index as a Predictor of Response to Prostate Radiotherapy in Men with Newly Diagnosed Metastatic Prostate Cancer: An Exploratory Analysis of STAMPEDE's "M1|RT Comparison".
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024 Mar 14
Efficacy of Poly(ADP-ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene-Mutated Metastatic Castration-Resistant Prostate Cancer: A US Food and Drug Administration Pooled Analysis.
JAMA oncology, 2019-04-01
Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade.
JCO precision oncology, 2022 Jun
PARP Inhibitor Insensitivity to Monoallelic Mutations in Microsatellite Instability-High Cancers.
The Lancet. Oncology, 2023 Apr
Testosterone suppression plus enzalutamide versus testosterone suppression plus standard antiandrogen therapy for metastatic hormone-sensitive prostate cancer (ENZAMET): an international, open-label, randomised, phase 3 trial.
Cancers, 2022 Nov 18
PSMA PET for the Evaluation of Liver Metastases in Castration-Resistant Prostate Cancer Patients: A Multicenter Retrospective Study.
European urology, 2023 Jul 05
Diagnostic Performance and Safety of Positron Emission Tomography with F-rhPSMA-7.3 in Patients with Newly Diagnosed Unfavourable Intermediate- to Very-high-risk Prostate Cancer: Results from a Phase 3, Prospective, Multicentre Study (LIGHTHOUSE).
The Journal of urology, 2023 Apr 26
Diagnostic Performance and Safety of F-rhPSMA-7.3 Positron Emission Tomography in Men With Suspected Prostate Cancer Recurrence: Results From a Phase 3, Prospective, Multicenter Study (SPOTLIGHT).
The Prostate, 2023 May 27
First, do no harm: The unclear benefit of lifelong castration for patients with metastatic prostate cancer.
BMC Cancer, 2019 Aug 19
Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial.
BMC Cancer, 2020 May 5
Stereotactic ablative radiotherapy for the comprehensive treatment of 1-3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial.
Chest, 2007-07
Natural history of stage I non-small cell lung cancer: implications for early detection.
The Journal of urology, 2017-08
An Update of the American Urological Association White Paper on the Prevention and Treatment of the More Common Complications Related to Prostate Biopsy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015 Feb 17
Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer.
Practical radiation oncology, 2024 Jul 15
Target Volume Optimization for Localized Prostate Cancer.
European urology, 2021 Aug 28
The Additive Diagnostic Value of Prostate-specific Membrane Antigen Positron Emission Tomography Computed Tomography to Multiparametric Magnetic Resonance Imaging Triage in the Diagnosis of Prostate Cancer (PRIMARY): A Prospective Multicentre Study.
European urology oncology, 2021 Apr 10
Using Prostate Imaging-Reporting and Data System (PI-RADS) Scores to Select an Optimal Prostate Biopsy Method: A Secondary Analysis of the Trio Study.
European urology, 2021 Dec 06
Radical Prostatectomy Without Prior Biopsy Following Multiparametric Magnetic Resonance Imaging and Prostate-specific Membrane Antigen Positron Emission Tomography.
The Journal of urology, 2024 Jun 17
Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by F-Labeled Prostate-Specific Membrane Antigen-Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-Center, Prospective, Single-Arm Trial.
The New England journal of medicine, 2024 Sep 15
Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021 Apr 29
Apalutamide in Patients With Metastatic Castration-Sensitive Prostate Cancer: Final Survival Analysis of the Randomized, Double-Blind, Phase III TITAN Study.
The New England journal of medicine, 2024 Mar 07
Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024 Sep 16
Darolutamide in Combination With Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer From the Phase III ARANOTE Trial.
N Engl J Med,
Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
Lancet, 2023 Jun 02
Atezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): a multicentre, randomised, open-label, phase 3 trial.
European urology, 2023 Apr 07
Head-to-head Comparison of the Diagnostic Accuracy of Prostate-specific Membrane Antigen Positron Emission Tomography and Conventional Imaging Modalities for Initial Staging of Intermediate- to High-risk Prostate Cancer: A Systematic Review and Meta-analysis.
Radiology, 2019 Sep 10
Diagnostic Accuracy of Multiparametric MRI versus Ga-PSMA-11 PET/MRI for Extracapsular Extension and Seminal Vesicle Invasion in Patients with Prostate Cancer.

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