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Neurology

General Internal Medicine   

Questions discussed in this category

What types of cardiac conduction abnormalities would lead you to avoid using tricyclic antidepressants?
6 Answers available
Do you typically give GI prophylaxis when providing patients with steroid taper for status migrainosus?
3 Answers available
In ischemic stroke patients with low LDL levels (<30-50 mg/dl), would you consider lowering LDL levels to lower values without concern for any side effects?
How would you adjust statin therapy in these patients?
4 Answers available
When do you consider attributing isolated psychosis to an acute ischemic stroke?
1 Answer available
When would you consider treatment with steroids in patients with diabetic radiculoplexus neuropathy?
Are there any alternative treatments?
1 Answer available
How do you approach new onset idiopathic intracranial hypertension (IIH) with someone who has history of systemic lupus erythematosus? Would you consider this to be neuropsychiatric SLE (NPSLE) manifesting as IIH?
How do you approach someone with a history of SLE that has been well controlled for decades on CellCept and Plaquenil, who develops dizziness with a w...
2 Answers available
When do you use seizure prophylaxis in patients on clozapine?
7 Answers available
How do you approach a patient who develops a rest tremor after chemotherapy?
3 Answers available
What work-up and treatment do you recommend for exertional headaches?
1 Answer available
Do you make any dose adjustments for patients with ESKD who are on apixaban and do not otherwise meet criteria for reduced dosing?
2 Answers available
How do you identify patients with false positive AcHR antibodies?
In patients who have positive AcHR antibody, how do you screen for those who are falsely positive?
1 Answer available
How long would you continue chronic transfusion therapy for adult sickle cell patients who have had a stroke?
Is treatment indefinite or do you consider discontinuing chronic transfusions at some threshold?
2 Answers available
Do you recommend any medical management for patients with evidence of intracranial atherosclerosis without evidence for stroke?
2 Answers available
What is your clinical threshold for treating a potential monoclonal gammopathy of thrombotic significance?
New data suggests monoclonal gammopathies can be associated with thrombotic events. Is your practice changing to include monoclonal gammopathy evaluat...
1 Answer available
What leads you to suspect that a foot drop is secondary to a myopathy rather than a neuropathic process?
4 Answers available
What is the importance of finding a positive titer for TS-HDS and what treatment would be advised for these patients?
2 Answers available
How do you treat extrapyramidal symptoms secondary to anti-psychotic use in patients who have not benefited from cogentin or benadryl?
4 Answers available
At what point should aspirin therapy for stable cardiovascular disease be discontinued in patients with a diagnosis of chronic cerebral microbleeds or possible Cerebral Amyloid Angiopathy?
2 Answers available
For stroke patients with ablated paroxysmal atrial fibrillation without known recurrence and ICAD, would you recommend dual antiplatelet therapy or anticoagulation with or without an antiplatelet agent?
What is the duration of each treatment choice and which drug is preferred by either group? What else should we take into consideration when deciding o...
2 Answers available
Would you recommend dual antiplatelet therapy or anticoagulation for a patient previously on aspirin who has a breakthrough stroke with history of CADASIL?
2 Answers available
What is the optimal antithrombotic management, if at all, in patients with incidentally identified findings of multiple silent embolic appearing cerebral infarcts?
3 Answers available
What workup do you recommend for otherwise healthy migraine patients that develop dizziness with episodes?
1 Answer available
What is the utility of a hypercoagulability workup in recurrent cryptogenic stroke, and what specific tests would you recommend?
Is there any utility in predominantly venous hypercoagulability labs?
7 Answers available
What type of visual disturbance qualifies as a visual aura?
Visual aura is commonly described as a scintillating scotoma. In practice, there is a much wider spectrum of visual symptoms in the migraine populatio...
2 Answers available
Would you consider using DOACs as a bridge to warfarin instead of heparin or LMWH?
For example, would you consider this method in an ESRD/HD patient with antiphospholipid syndrome who had a major bleed requiring reversal of warfarin ...
4 Answers available
Do you recommend routine neurosyphilis testing in patients being evaluated for dementia?
1 Answer available
How do you manage pregnant individuals with newly diagnosed idiopathic intracranial hypertension?
1 Answer available
Can anti-cardiolipin or anti-beta-2 glycoprotein antibodies cause prolonged PTT in the absence of a lupus anticoagulant?
Labs with normal PT, but prolonged PTT (47 sec, ULN 40 sec) that does not correct on immediate mix. Lupus anticoagulant negative (DRVVT and hexagonal ...
1 Answer available
Are there any contraindications using nurtec in patients with headaches in the setting of recent RCVS?
1 Answer available
What factors would influence your decision to use or avoid heparin bridging in patients with mechanical heart valves resuming anticoagulation after intracerebral hemorrhage?
In light of a publication by Sakusic et al., PMID 39102615 suggests an increased risk of ICH expansion in patients with heparin bridge compared to sta...
1 Answer available
When should one consider obtaining a cardiac MRI in ischemic stroke patients?
What is the utility of it? 
2 Answers available
How would you approach the workup of unilateral chorea with a normal MRI?
2 Answers available
What is your approach to secondary stroke prevention in patients with atrial fibrillation and intracranial stenosis (>70%)?
6 Answers available
When do you attribute tremors to lamotrigine?
1 Answer available
Do you obtain an MSLT or start empiric therapy with modafinil in patients with residual excessive daytime sleepiness despite optimal adherence to PAP therapy?
In patients with an average of less than 5 respiratory events per hour, adequate sleep duration and hygiene were confirmed on the sleep log, absent ca...
5 Answers available
Do you try to treat the acidosis resulting from acetazolamide in patients with IIH?
1 Answer available
How do you approach the medical evaluation of new onset psychosis in elderly patients?
1 Answer available
How do you interpret CSF pleocytosis in the context of significant leukocytosis on CBC?
For example, a patient with 100 WBCs in CSF with a peripheral WBC 43k/mm3 due to AML.
1 Answer available
What are the differential and workup for a patient with findings suggestive of idiopathic intracranial hypertension without papilledema on examination?
4 Answers available
How do you use cardiac biomarkers, if at all, in prognostication for patients with ischemic stroke?
In light of data from Chang et al in J Neurol Aug 2024 showing that biomarkers such as LDH and troponin were associated with adverse clinical outcomes...
0 Answers available
How does one interpret an SPEP showing potentially obscured but non-quantifiable M-spike however an IFE showing monoclonal protein?
Can you elaborate on reasons for a non-quantifiable SPEP and how does one follow the paraprotein?
3 Answers available
How long do oscillopsia and ataxia secondary to thiamine deficiency last after completing repletion?
1 Answer available
What other conditions should you consider in someone with presumed Tolosa Hunt but without significant improvement on steroid therapy?
2 Answers available
How do you evaluate a patient with MGUS and peripheral neuropathy?
Can you explain when would you consider light chain amyloidosis work up with fat pad biopsy?
1 Answer available
What typical lab tests do you send off for evaluation of neuropathy?
When do you use specialized panels for neuropathy? Which panels do you typically use?
2 Answers available
Do you ever use ocular ultrasound in evaluation of papilledema?
1 Answer available
What role do anti-seizure medication levels, such as levetiracetam, serve in seizure-free patients?
Is there a role in adjusting the medication doses to levels in seizure-free patients; or is it sufficient to just monitor patients clinically?
5 Answers available
What treatment do you use for stroke prevention in cervical artery dissection?
In light of the STOP-CAD study
2 Answers available
What prompts you to procure EEG and/or imaging in patients presenting with multiple simple febrile seizures?
1 Answer available
What would be the differential and initial workup for tongue fasciculation?
5 Answers available
For which stroke patients, if any, do you recommend implantable loop recorder for long-term cardiac monitoring and why?
It seems clear that longer monitoring yields more AF detected. What is less clear to me is whether all ILR-detected AF is relevant and merits anticoag...
4 Answers available
How do you treat patients with stroke thought to be secondary to Lambl excrescence?
2 Answers available
What is your diagnostic approach to patients referred for central sleep apnea on PSG but normal overnight EEG and MRI?
1 Answer available
How do you counsel patients who experience diarrhea from mycophenolate mofetil (Cellcept)?
Do you generally recommend anti-diarrheals, dietary modifications, or consider this an unacceptable side effect and move to other therapies? 
2 Answers available
How do you manage patients with atrial fibrillation having a thromboembolic infarct despite being on adequate anticoagulation?
Would you recommend left atrial appendage occlusion with or without continuing anticoagulation? In light of Maarse et al., JAMA Neurology 2024.
3 Answers available
When do you consider starting short-term DAPT in patients who present more than 24 hours after the onset of a high-risk TIA or minor stroke syndrome?
In light of the INSPIRES trial publication.
4 Answers available
What postural change in FVC is suggestive of respiratory muscle weakness?
2 Answers available
What is the expected timeframe for the development of radiation myelitis and therapies that have helped with neurologic symptoms?
4 Answers available
How would you prioritize physiotherapy and cognitive behavioral therapy for functional movement disorders in a resource-limited setting where access to both might be constrained?
In light of the publication by Macías-García et al., PMID 39102249 on combined physiotherapy and cognitive behavioral therapy for functi...
1 Answer available
How would you approach the workup and management of a young patient with recurrent biannual non-scarring oral ulcers and new onset neurologic symptoms with associated CNS white matter lesions concerning for Behcet’s?
1 Answer available
How do you approach use of DMARDs and/or biologics for inflammatory arthritis in patients with a history of seizure disorder on anti-epileptic medications?
Is there any concern for drug interactions of DMARDs and/or biologics with anti seizure medications?
1 Answer available
Do you send CSF or serum ACE levels in the workup of neurosarcoidosis?
If not, are there any serum or CSF tests you consider to be helpful?
3 Answers available
How do you approach long-term blood pressure parameters in ischemic stroke patients with severe symptomatic intracranial stenosis?
How do you balance between having a higher long-term blood pressure to prevent flow failure and leading to worsening of stenosis or occlusion from the...
2 Answers available
Do you use amyloid lowering therapy in patients on chronic anticoagulation?
How do you counsel them on the risk?
1 Answer available
What workup do you recommend for patients with symptoms suggestive of saphenous neuropathy?
1 Answer available
What is your approach to DVT prophylaxis in patients who require IVIG but are at increased risk for thrombotic events?
E.g., a patient with newly diagnosed CIDP who is wheelchair-bound.
2 Answers available
How do you workup patients with neuropathy suspected to be secondary to sarcoid?
Is a biopsy or EMG helpful in confirming the etiology? What is the best treatment for sarcoid neuropathy?
1 Answer available
How do you dose gabapentin in patients with renal failure?
3 Answers available
Do you recommend thiamine for patients presenting with acute symptoms of TGA?
1 Answer available
Does aspirin dose (81 mg vs 325 mg) matter for secondary stroke prevention?
Should some patients get 325 mg instead of 81mg at least for a certain amount of time, such as patients in the acute phase of ischemic stroke or patie...
1 Answer available
Would you recommend a CT venogram or MR venogram in patients with concern for venous sinus thrombosis?
1 Answer available
Does anyone utilize P2Y12 assays to determine if clopidogrel may be ineffective when used for DAPT?
If yes, if the assay shows they are a non-responder, do you switch to ticagrelor?
2 Answers available
How do you apply the 2HELPS2B score into clinical decision making for determining duration of cEEG testing?
1 Answer available
What imaging do you recommend for patients with suspected CSF leak?
2 Answers available
How do you counsel newly diagnosed patients with ALS on dietary recommendations?
Patients often see a dietician at ALS centers, but what do you discuss with patients before they have a formal consult with a dietician?
4 Answers available
What treatments options may be considered in patients with POTS who also need daily diuretics to treat heart failure and are already wearing compression garments?
3 Answers available
How do you manage stroke-related abulia?
1 Answer available
How do you counsel patients with ALS on the benefits of enteral nutrition?
E.g., PEG tube placement.
3 Answers available
How would you best evaluate and manage a patient with hemiplegic migraine and a history of ischemic stroke?
1 Answer available
Do you favor the use of maximal inspiratory/expiratory pressure measurement or supine spirometry in the evaluation of a patient with suspected respiratory muscle weakness?
1 Answer available
How do you utilize cytokine panels in your clinical practice?
Is there utility when classic inflammatory markers (ESR,CRP) or disease specific markers (C3, C4, dsDNA) do not correlate with patients disease activi...
1 Answer available
How do you manage patients with a prior intracerebral hemorrhage from probable cerebral amyloid angiopathy who develop new small vessel ischemic infarcts?
Would you consider using cilostazol instead of antiplatelets?
1 Answer available
How do you treat persistent headache after RCVS?
2 Answers available
When do you consider stenting in patients with recurrent stroke with ICAD?
2 Answers available
What is the preferred approach to managing non-occlusive or partially occlusive venous sinus thrombosis?
1 Answer available
When would you consider neuro-stimulants in post-stroke patients?
Is there management guidance on when to start after stroke onset?
3 Answers available
Do you get volumetric MRI in all patients with cognitive difficulties?
1 Answer available
Would you consider using IVIG for POTS in the absence of any clear autoimmune condition or abnormal antibodies?
4 Answers available
When is brain biopsy useful/warranted as part of the diagnostic work-up in patients with suspected primary CNS angiitis?
3 Answers available
How do you interpret the results of oligoclonal bands ordered to evaluate for demyelinating disease in patients with brain MRI lesions of unclear etiology?
Does the number of bands matter in making the diagnosis? Does it make a difference whether isolated or also in the serum? How do you interpret other r...
1 Answer available
Is there any benefit from oral vs topical steroids in herpes zoster opthalmicus?
Would the management change if there were complications with optic neuritis?
1 Answer available
When do you use MRI to evaluate patients with spontaneous subdural hemorrhage?
In light of the evidence associating cerebral amyloid angiopathy (CAA) with subdural hemorrhage; Rivier et al., PMID 38147345.
1 Answer available
How do you manage patients with ice-pick headaches?
2 Answers available
Do you typically use NOACs or Lovenox in patients with stroke due to hypercoagulability from malignancy?
1 Answer available
Do you avoid SSRIs in patients with a history of RCVS?
2 Answers available
Do you repeat a lumbar puncture in a patient living with HIV diagnosed with and treated for neurosyphilis and if so, when?
1 Answer available
When do you re-image patients with a diagnosis of venous sinus thrombosis?
2 Answers available
How would you manage cognitive changes in a patient with memory impairment and significant brain atrophy with no diagnostic testing consistent with Alzheimer's disease?
1 Answer available
Would you recommend genetic polymorphic testing before the initiation of antiplatelet medication in patients with ICAD?
4 Answers available
Do you utilize post-vaccination IgG titers to detect common variable immunodeficiency in patients who are about to start or are actively on B cell depleting therapy?
2 Answers available
Would you use sumatriptan in a patient with a history of cerebral aneurysm rupture?
1 Answer available
How do you manage incidentally found venous sinus thrombosis?
5 Answers available
Do you typically obtain an EEG in patients undergoing workup for cognitive dysfunction?
5 Answers available
Would you consider dual antiplatelet therapy for stroke prevention for ICAD in patients with a history of SAH?
2 Answers available
What criteria are used to choose a specific dose of aspirin in ischemic stroke?
We have seen 81 vs 162 vs 325 mg up to 1300 mg.
3 Answers available
How would you interpret a temporal artery biopsy demonstrating focal chronic inflammation in the adventitia associated with small adventitial vessels and nerves without inflammation of the intima and media and without giant cells?
2 Answers available
What is the normal range of spinal tap opening pressure?
Are there variations with different patient populations?
3 Answers available
What duration of dual antiplatelet therapy do you use for secondary prevention of ischemic stroke due to intracranial atherosclerotic disease?
While some have the practice of 90 days per SAMMPRIS trial, the lower rates of ischemic stroke in the medical therapy group were driven by events with...
8 Answers available
Would a surgical decompression be indicated in a patient with amyloidosis and severe median neuropathy at the wrist?
1 Answer available
What management do you recommend in patients with backpack palsy?
1 Answer available
How would you approach additional workup and management of a patient with active Crohn’s disease, who has multiple lung and brain nodules, with lung pathology demonstrating necrotizing granulomatous inflammation and brain biopsy with granulomatous inflammation and medium-large vessel vasculitis?
The patient is on mesalamine for Crohn’s and CellCept and HCQ for skin manifestations (currently on hold during workup). The infectious workup i...
1 Answer available
Do you start aspirin for patients with incidentally found intracranial vertebral stenosis?
3 Answers available
In patients with suspected RCVS, is there a role for preventative CCB if headache has resolved/now asymptomatic?
3 Answers available
Does IVIG or subcutaneous Ig interfere with monoclonal antibody therapy (i.e. dupilumab, infliximab, rituximab, etc)?
How should IVIG and either biologic injections or infusions be spaced?
2 Answers available
Would you avoid combining JAK inhibitors with IVIG given the risk of thromboembolism?
4 Answers available
How would you evaluate and treat a disabling tongue tremor?
The tremor fluctuates and can last for 45 minutes with the inability to talk, eat, or drink.
1 Answer available
What workup do you initiate for thoracic outlet syndrome?
1 Answer available
How do you counsel patients with postmedian sternotomy plexopathy?
1 Answer available
How do you manage cases of levodopa intolerance due to nausea or drowsiness?
Particularly when ondansetron and taking it with food are not beneficial.
1 Answer available
When do you recommend neuropsychiatric testing in patients with post-concussive syndrome?
4 Answers available
Do you routinely obtain baseline vascular imaging (CTA, MRA, PET) in patients with suspected GCA, but negative temporal artery biopsy?
Per 2021 GCA Vasculitis Guidelines: low evidence, but conditional recommendation for CTA neck, chest, abd/pelvis. Is anybody following this or do you ...
2 Answers available
What is your approach to determining if an SPEP abnormality is causal or coincidental in peripheral neuropathy work up?
1 Answer available
When do you consider genetic testing in patients with concern for hemiplegic migraine?
2 Answers available
How do you treat patients with hemiplegic migraine?
2 Answers available
When do you consider use of ketamine in patients with migraine with aura?
1 Answer available
How do you manage incidentally identified pituitary lesions on brain imaging?
What workup do you typically recommend?
1 Answer available
How do you recommend tapering IVIG in patients whose inflammatory myositis has achieved remission?
4 Answers available
When do you restart antiplatelet therapy in patients with hemorrhagic conversion of stroke?
2 Answers available
How long can you treat dermatomyositis with IVIG?
3 Answers available
Would you recommend anti-platelet or anticoagulation in a patient with recurrent strokes, CADASIL, and Antiphospholipid Syndrome?
1 Answer available
How do you diagnose and manage patients with hypnagogic shooting headache?
What are the diagnosis and treatment for hypnagogic shooting headache?
2 Answers available
How frequently do you monitor EKGs for patients newly initiated on lacosimide?
1 Answer available
What workup do you recommend on patients with suspected ischemic cranial nerve six palsy?
1 Answer available
Considering only cerebrovascular indications, are there circumstances in which you would use aspirin along with a DOAC in patients with atrial fibrillation and stroke?
6 Answers available
In antiphospholipid syndrome with recurrent strokes, would you consider adding antiplatelets to warfarin?
Also how would you manage this perioperatively?
7 Answers available
Would testing for ATTR cardiac amyloidosis be considered in an older patient with bilateral carpal tunnel surgeries and multiple spinal stenosis surgeries, but no obvious cardiac symptoms?
1 Answer available
Is intracranial hemorrhage a contraindication for valproic acid?
1 Answer available
How slowly do you taper a dopamine agonist to prevent dopamine agonist withdrawal syndrome (DAWS)?
6 Answers available
What is your approach to managing a patient with a history of tardive dyskinesia on a VMAT2 inhibitor, presenting with parkinsonism and found to have an abnormal DAT scan?
1 Answer available
How do you manage patients with post spinal tap headaches?
Are there any diagnostic tests or imaging that you recommend?
3 Answers available
How do you approach a patient with atrial fibrillation on apixaban who has a new cardioembolic stroke?
3 Answers available
In patients with Afib on anticoagulation and concurrent intracranial atherosclerotic disease, would you consider adding an anti-platelet to anticoagulation if there are recurrent events that could be related to the ICAD?
1 Answer available
Does pregabalin contribute to esophagitis or gastroparesis?
1 Answer available
In patients with embolic stroke and a PFO, how often do you go beyond venous Doppler of the lower extremities to screen for DVT (e.g. MRV or CTV abdomen and pelvis)?
Would you anticoagulate if this screening is negative pending PFO closure?
1 Answer available
What work-up do you recommend in patients with early-onset dementia?
Which genetic/other testing should be considered in an early-onset dementia work-up? 
1 Answer available
Does the presence and location of cerebral microbleeds affect your decision for antithrombotic treatment in patients with atrial fibrillation?
Do you distinguish between primary and secondary prevention? Wilson et al., PMID 31130428 is helpful, but curious how people apply this data in practi...
3 Answers available
What is your approach to elevated CK in patients without clinical or serologic evidence of immune mediated myopathy?
1 Answer available
Is there any clinical benefit in referring patients with SLE or Sjogren's with cognitive impairment for neuropsychological testing?
How do you differentiate symptoms related to centralized pain syndrome from possible cognitive dysfunction?
2 Answers available
How do you evaluate patients with suspected pseudo-dementia?
1 Answer available
What is your preferred workup for patients who present with concern for autonomic neuropathy?
2 Answers available
How do you diagnose and treat patients with cervicogenic headache?
5 Answers available
What would be the main indications for opting for biosimilars over an original biologic, outside of insurance barriers?
Are there any instances where you would prefer a biosimilar rather than the reference product? 
2 Answers available
What additional testing besides LAC/APLS, factor V Leiden, prothrombin gene mutation, JAK 2 do you draw for unprovoked cerebral venous sinus thrombosis?
1 Answer available
Would you recommend PFO closure in patients >60 years old with presumed paradoxical embolism as their mechanism of stroke?
2 Answers available
Do patients on eculizumab or ravulizumab require repeat vaccination against meningococcal infection after a certain interval?
1 Answer available
When do you recommend lumbar puncture in patients with concern for memory loss?
1 Answer available
How do you approach the workup of transverse myelitis without any abnormality on spine MRI?
If a patient has classic TM symptoms but a normal MRI, are there specific causes you look for?
4 Answers available
When do you consider intrathecal baclofen pump in patients with acquired spasticity?
For example, patients with spasticity due to hypoxic or anoxic brain injury.
4 Answers available
Do you typically get muscle MRI in patients with symptoms of myopathy?
1 Answer available
How do you approach the diagnostic workup for patients with suspected Fabry's disease?
1 Answer available
Would you recommend switching to DAPT for patients on anticoagulation who develop symptoms of a TIA secondary to ICAD?
3 Answers available
How do you manage a patient with progressive cerebellar ataxia and positive cardiolipin antibodies?
Do you wait 12 weeks for confirmation to begin treatment if patient is declining?
1 Answer available
What antithrombotic regimen do you recommend prior to and in anticipation of CEA for patients with symptomatic carotid stenosis?
2 Answers available
What is your approach to initiating and titrating midodrine for both inpatient and ambulatory settings?
1 Answer available
When do you recommend genetic testing in patients with neuropathy?
1 Answer available
How do you approach the symptomatic management of central vertigo in a patient with minimal improvement on (or contraindication to) meclizine?
1 Answer available
When is a paraneoplastic panel indicated when working up patients with neuromuscular conditions?
0 Answers available
How will you treat a young man with recurrent cryptogenic strokes with no identifiable cause, with MTHFR A1298C homozygous mutation and normal homocysteine level?
1 Answer available
Are there any risk factors for IO induced rhabdomyolysis and how do you approach and manage it?
2 Answers available
Is LP indicated for patients with recurrent thunderclap headaches over a 4-week period and negative head imaging for SAH?
2 Answers available
How do you approach the management of patients on lamotrigine who develop a minor rash?
Should one restart lamotrigine or look for an alternative? If no other alternative available, is slow titration vs regular titration preferred?
4 Answers available
How do you manage a diabetic patient with generalized myasthenia gravis post thymectomy previously treated with Imuran?
1 Answer available
How do you approach the diagnosis and treatment of recurrent neurosyphilis in a previously treated patient?
Are VDRL titers useful?
1 Answer available
Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?
Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?
3 Answers available
When do you consider immunosuppression in patients with Sjogren's neuropathy?
3 Answers available
How do you approach the workup of a patient with incidentally found pachymeningitis?
1 Answer available
What is your practice for the timing of resumption of oral anticoagulation after ICH?
Do you order any imaging beforehand? Are there other studies that you order?  
1 Answer available
Why do we not typically see features of rhabdomyolysis or acute kidney injury with idiopathic inflammatory myopathies?
1 Answer available
How do you evaluate asymptomatic patients referred for benign intracranial hypertension?
If patients are asymptomatic, what work up do you typically proceed with?
3 Answers available
What symptomatic management do you recommend in patients with post LP headaches?
When do you consider a blood patch? 
1 Answer available
How do you manage orthostatic hypotension in patients with Parkinsonian syndromes?
We often use abdominal binders and compression stockings, in addition to hydration and midodrine/fludricortisone. However, are there more targeted the...
4 Answers available
How do you approach the workup for patients with hyperCKemia and positive NXP2 with no clinical symptoms?
1 Answer available
What is the most effective treatment for a patient with persistent post-stroke headache?
4 Answers available
What is the recommended management approach in regard to diagnostic evaluation and treatment for patients with homocystinuria and cerebral thrombosis?
Do we prophylactically place patients on anticoagulation after one episode? Besides MRI/MRV brain, are there other diagnostic imaging that should b...
1 Answer available
When do you use levocarnitine in patients on Depakote therapy for seizures?
1 Answer available
How do you approach the initiation and/or continuation of antiseizure medication in a patient who has experienced one lifetime seizure with a normal EEG and MRI with a comorbid health condition that is associated with an increased risk of epilepsy?
(e.g. Alzheimer's disease)?
1 Answer available
How do you approach a mildly positive finding on an autoimmune encephalitis panel when there is no other evidence of encephalitis (such as elevated CSF protein, abnormal imaging, or EEG findings)?
For example, a GAD65 Ab of 0.07 when the cut-off is 0.02. Does this answer change if you consider adult vs pediatric populations?
2 Answers available
When do you trial pyridostigmine in a patient with suspected myasthenia gravis?
Is there a role for using a trial of pyridostigmine as a diagnostic aid in a patient with suspected (but not confirmed) myasthenia gravis?
1 Answer available
Does the overall conclusion of the CHANCE-2 trial make ticagrelor + ASA a worthwhile transition given the data showing cumulative hazard of stroke diverged during the first week and was subsequently similar, which suggests the benefit of ticagrelor over clopidogrel is seen predominantly soon after stroke?
4 Answers available
Do you ever do surveillance MR imaging in patients with stable exam and history of cardioembolic stroke?
1 Answer available
How do you decide on initiation of treatment with steroids or immunomodulatory therapy in patients with statin-induced myopathy versus statin-induced autoimmune necrotizing myopathy?
In patients presenting with likely statin-induced myopathy versus statin-induced autoimmune necrotizing myopathy - how do you approach the decision re...
3 Answers available
Would you generalize the data from the CHANCE-2 trial to a broader clinic population given that the study was specific to Han Chinese patients?
How do you plan to incorporate the results of the CHANCE-2 trial (Wang et al., PMID 34708996) in your own practice?
3 Answers available
Do you recommend genetic testing after a patient on clopidogrel has a stroke based on the results of the CHANCE-2 trial?
3 Answers available
Would you consider anticoagulation for a young patient with a recent embolic stroke and newly diagnosed global cardiac hypokinesis with ejection fraction of less than 25%?
No thrombus detected on echocardiogram and no evidence of atrial fibrillation is present.
1 Answer available
What workup do you do for patients who have PL-7 elevation when screening for myopathy?
2 Answers available
Would you recommend short-term dual antiplatelet therapy for a patient who received tPA, and is otherwise eligible for dual antiplatelet therapy per POINT or SAMMPRIS trial?
3 Answers available
How do you work up patients who present with elevated myoglobin in the setting of normal creatinine kinase and exercise intolerance?
For patients who present with elevated myoglobin in the setting of normal creatinine kinase and exercise intolerance, what work up process do you typi...
1 Answer available
How do you interpret a mildly positive NT5C1A lab test in patients with hyperCKemia?
1 Answer available
Do you always initiate hypercoagulable work up in a patient with recurrent stroke?
If so, what would you consider ordering?
1 Answer available
How would you approach protein S deficiency found on hypercoagulability work-up in a patient with a post-operative central retinal vein occlusion?
In the setting of no personal or family history and no other risk factors for thrombosis, is systemic anticoagulation warranted if local treatments (e...
4 Answers available
Are adults with IDD at increased risk for adverse events like NMS or central anticholinergic syndrome?
1 Answer available
At what point do you recommend muscle biopsy in the workup for myositis?
1 Answer available
How does the FDA safety warning on the cardiac effects of lamotrigine, based on in vitro data, inform your clinical practice?
This question is intended to include consideration of cardiac diagnostic screening, as well as initiation & maintenance of lamotrigine, in epileps...
1 Answer available
How long after starting anticoagulation would you remove an IVC filter in a patient with a DVT presenting with stroke and PFO which is now closed?
1 Answer available
In what conditions can you see roving eye movements?
1 Answer available
Can giant cell arteritis present with a partial cranial neuropathy?
3 Answers available
How do you approach the treatment of SREAT (steroid-responsive encephalopathy with autoimmune thyroiditis) after initial pulse dose steroids?
1 Answer available
How does evidence of cerebral amyloid angiopathy/microbleeds affect choices for secondary stroke prevention in patients with a history of ischemic stroke and atrial fibrillation?
How do you approach secondary stroke prevention for patients with ischemic stroke, atrial fibrillation, and signs of cerebral amyloid angiopathy/micro...
1 Answer available
When would you suspect metabolic myopathy and what is your approach to initial workup?
2 Answers available
What is the role of x-ray of the cervical or lumbar spine in patients presenting with radicular symptoms?
I teach my students/residents that they should hardly ever get routine X-rays in patients presenting with radicular symptoms. MRI far better for seein...
4 Answers available
At what stage of the neuropathy workup do you screen for B6 toxicity?
2 Answers available
How do you treat lupus-associated small fiber neuropathy?
1 Answer available
Is antiplatelet or anticoagulant therapy preferred for the secondary prophylaxis of cryptogenic stroke in a patient with underlying malignancy?
4 Answers available
What is the significance of elevated fractionated catecholamines in POTS?
What would be the next steps in these cases?
2 Answers available
How would you approach evaluation and treatment of a patient on pembrolizumab therapy who presents with symmetric, proximal, upper extremity and lower extremity painful weakness without an elevated CK?
1 Answer available
Have you seen patients who develop neuromuscular disorders following COVID-19 vaccination?
1 Answer available
How do you approach the workup and management of patients with suspected functional neurologic disorders?
What testing do you typically proceed with?
1 Answer available
In which subset of patients with concussion do you recommend further brain imaging?
Do you typically recommend MRI or CT?
1 Answer available
At what point is a skin biopsy indicated in patients with neuropathy?
1 Answer available
Do you always perform temporal artery biopsy in patients with positive inflammatory markers and high clinical suspicion of GCA?
2 Answers available
Is either ESR or CRP more sensitive or specific for the diagnosis of GCA?
Additionally, what is the current role for temporal artery ultrasound in workup for GCA?
3 Answers available
How do you treat post-IVIG headache that is not responsive to Tylenol or NSAIDs?
Specifically, how do you treat the delayed headache, not the headache that develops during the infusion where pre-hydration and slowing down the rate ...
4 Answers available
What is the utility in repeating a temporal ultrasound (US) in a previously US diagnosed positive GCA patient who has received treatment and is presenting with recurrent GCA symptoms?
1 Answer available
For patients with atrial fibrillation on DOAC, when should they resume DOAC after a thalamic bleed without intraventricular bleed?
How does presence of intraventricular hemorrhage change your recommendations?
2 Answers available
How do you manage a patient with inclusion body myositis?
Is there a role for immunomodulatory therapy?
2 Answers available
What workup do you recommend for patients with stabbing headaches?
How do you approach treatment?
1 Answer available
What DHE migraine protocol works best for acute treatment both in terms of dosage and timeframe?
1 Answer available
What is the importance of finding a positive titer for FGFR3 and what treatment would be advised for these patients?
1 Answer available
When would you consider checking JC virus prior to initiating biologic therapy?
1 Answer available
What suspected myositis manifestations drive you to start empiric therapy before the work-up is complete?
Myositis specific antibodies and pathology results often take weeks to result.  In which cases do you start therapy before the diagnosis is solid...
1 Answer available
How do you determine if a patient is safe to drive after having a PCA infarct?
What is the best way to determine if patients with new PCA territory infarct can drive? Upon discharge from the hospital, do you routinely refer them ...
1 Answer available
What is your steroid-sparing agent of choice to treat GCA given the current tocilizumab shortage?
Thoughts on sarilumab vs methotrexate, or just treat with steroids alone
1 Answer available
When is the best time to consider left atrial appendage closure for secondary stroke prevention in patients with atrial fibrillation?
For example, with a Watchman device? What is the evidence behind this?
1 Answer available
Is an EMG/NCS required to clinically diagnose Guillain barre syndrome?
1 Answer available
How do you manage oxaliplatin-induced acute peripheral nerve hyperexcitability?
Patients can develop sensory and motor symptoms such as paresthesias, jaw/facial pain and stiffness, cramping and twitching, ptosis and vision changes...
2 Answers available
In patients with recurrent ischemic infarcts on the same side as an internal carotid artery lesion, is intervention warranted even if there is less than 50% obstruction?
When would you consider stenting or CEA even if there is less than 50 obstruction when no other etiology has been found?
1 Answer available
Do you recommend getting a muscle biopsy in a patient with suspected IMNM with statin exposure, weakness, elevated CK, and positive HMGCR antibody?
2 Answers available


Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-04-01
Phase III randomized, placebo-controlled, double-blind study of intravenous calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity (N08CB/Alliance).
Oncol Lett, 2015 Aug 11
FOLFIRINOX-induced reversible dysarthria: A case report and review of previous cases.
Muscle & nerve, 2003-02
Sensory neuropathy with monoclonal IgM binding to a trisulfated heparin disaccharide.
Muscle & nerve, 2012-06
Clinical and laboratory features of neuropathies with serum IgM binding to TS-HDS.
Muscle Nerve, 2022 Nov 29
A double-blind placebo-controlled pilot study of immunoglobulin for small fiber neuropathy associated with TS-HDS and FGFR-3 autoantibodies.
Muscle & nerve, 2019 Nov 06
Cryptogenic small-fiber neuropathies: Serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor-3.
Journal of clinical neuromuscular disease, 2021 Jun 01
Clinical Features and Treatment Response in Immune-Mediated Small Fiber Neuropathy with Trisulfated Heparin Disaccharide or Fibroblast Growth Factor Receptor 3 Antibodies.
Journal of neurology, 2023 Jun 09
TS-HDS autoantibody: clinical characterization and utility from real-world tertiary care center experience.
Stroke, 2019-02
Ischemic Stroke and Internal Carotid Artery Web.
J Am Coll Cardiol,
Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial.
Neurology, 2015-09-29
Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE.
Stroke, 2017-08
Challenges in the Medical Management of Symptomatic Intracranial Stenosis in an Urban Setting.
Stroke, 2021 May 24
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.
Lancet (London, England), 2014-01-25
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
Circulation, 2019-08-20
Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.
Archives of neurology, 2009-06
Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments.
Muscle & nerve, 2013-04
Striational antibodies in a paraneoplastic context.
Muscle & nerve, 2016-08
P/Q- and N-type calcium-channel antibodies: Oncological, neurological, and serological accompaniments.
Muscle & nerve, 2017-07
GAD65 neurological autoimmunity.
Annals of neurology, 2017-07
Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients.
Headache, 1990-05
Repetitive intravenous DHE in the treatment of refractory headache.
Neurology, 1986-07
Repetitive intravenous dihydroergotamine as therapy for intractable migraine.
Headache, 1997-03
Continuous intravenous dihydroergotamine in the treatment of intractable headache.
J Pain Res, 2020 Apr 30
Updated Evaluation of IV Dihydroergotamine (DHE) for Refractory Migraine: Patient Selection and Special Considerations.
Headache, 2010 Jan 28
Outpatient home-based continuous intravenous dihydroergotamine therapy for intractable migraine.
N Engl J Med,
Trial of Tocilizumab in Giant-Cell Arteritis.
Lancet, 2016 Mar 04
Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial.
Arthritis Rheum,
Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis.
American heart journal, 2010-07
Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): design and rationale.
Lancet, 2021 Aug 27
Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.
Seminars in arthritis and rheumatism, 2012-06
Utility of erythrocyte sedimentation rate and C-reactive protein for the diagnosis of giant cell arteritis.
Arthritis Rheumatol, 2021 Jul 08
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.
Ann Rheum Dis, 2019 Jul 03
2018 Update of the EULAR recommendations for the management of large vessel vasculitis.
Mayo Clin Proc,
My Treatment Approach to Giant Cell Arteritis.
Journal of neurovirology, 2018-06
Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.
Neurology, 2019 Jan 11
RCVS score and diagnostic approach for reversible cerebral vasoconstriction syndrome.
Brain : a journal of neurology, 2016-05
Association of inclusion body myositis with T cell large granular lymphocytic leukaemia.
Scand J Rheumatol, 2018 May 18
Blood-flow restricted resistance training in patients with sporadic inclusion body myositis: a randomized controlled trial.
Postgrad Med J,
Post lumbar puncture headache: diagnosis and management.
Anesth Essays Res,
Role of Oral Prednisolone in the Management of Postdural Puncture Headache after Spinal Anesthesia in Urological Patients.
The New England journal of medicine, 2013-03-21
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
Neurology, 2013-08-13
An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke.
The New England journal of medicine, 2017-09-14
Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.
Circ Cardiovasc Interv, 2022 Jun 23
Transcatheter Closure of Patent Foramen Ovale in Older Patients With Cryptogenic Thromboembolic Events.
JAMA, 2021 Dec 14
Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.
JAMA Neurol, 2020 Jul 01
Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke.
JAMA Neurol, 2022 Nov 01
Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure.
Ann Rheum Dis, 2021 Jul 02
Ultrasound halo sign as a potential monitoring tool for patients with giant cell arteritis: a prospective analysis.
Muscle Nerve, 2021 May 04
Parsonage Turner syndrome after COVID-19 vaccination.
J Am Heart Assoc, 2020 Nov 23
Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study.
Am J Hematol,
Protein S abnormalities: a diagnostic nightmare.
Curr Opin Neurol,
Central vertigo.
Am Fam Physician,
Treatment of vertigo.
J Clin Neurol, 2011 Dec 29
Vestibular rehabilitation therapy: review of indications, mechanisms, and key exercises.
The New England journal of medicine, 2000-10-05
The neuropathic postural tachycardia syndrome.
Clinical science (London, England : 1979), 2001-04
Influence of posture on the Valsalva manoeuvre.
Current rheumatology reports, 2015-10
Myositis Mimics.
Curr Opin Rheumatol,
Myositis mimics: how to recognize them.
Contemp Neurol Ser,
The diagnosis of stupor and coma.
Stroke, 2016 Dec 20
Optimal Timing of Anticoagulant Treatment After Intracerebral Hemorrhage in Patients With Atrial Fibrillation.
Stroke, 2010 Oct 28
Optimal timing of resumption of warfarin after intracranial hemorrhage.
J Thromb Haemost, 2010 Apr 08
Management of anticoagulation following central nervous system hemorrhage in patients with high thromboembolic risk.
Lancet Neurol, 2021 Sep 03
Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial.
The New England journal of medicine, 2018-07-19
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
N Engl J Med, 2013 Jun 26
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
Ann Rheum Dis, 2017 Dec
2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups.
N Engl J Med, 2021 Oct 28
Ticagrelor versus Clopidogrel in Loss-of-Function Carriers with Stroke or TIA.
N Engl J Med,
Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.
Rheumatology (Oxford, England), 2017-06-01
A longitudinal cohort study of the anti-synthetase syndrome: increased severity of interstitial lung disease in black patients and patients with anti-PL7 and anti-PL12 autoantibodies.
Autoimmun Rev, 2012 Jul 05
Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity.
JAMA neurology, 2019-04-01
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.
Lancet Neurol, 2019 May 23
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.
JAMA Neurol,
Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.
Lancet Neurol, 2018 Jan 10
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study.
Cancer causes & control : CCC, 2010-03
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Atherosclerosis, 2001-06
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The American journal of clinical nutrition, 2008-10
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Circulation. Cardiovascular genetics, 2008-12
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012-01
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Human genetics, 2012-05
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.
PeerJ, 2013
Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.
Nature, 2016-08-18
Analysis of protein-coding genetic variation in 60,706 humans.
Am J Hum Genet, 1998 May
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Am J Reprod Immunol, 2011 Jan 18
Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss.
Am J Reprod Immunol, 2012 Aug 06
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome.
BMC Cancer, 2008 Nov 07
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
BMJ Case Rep, 2012 Nov 15
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation.
BMJ Case Rep, 2013 Jun 13
Bilateral consecutive optic neuropathy in a patient with thrombophilia.
Mol Biol Rep, 2010 Jun 08
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk.
Mol Biol Rep, 2010 Nov 16
Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases.
Nat Genet, 2008 Jul
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Proc Natl Acad Sci U S A, 2001 Mar 13
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Mol Biol Rep, 2018 Mar 29
CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children.
Transfus Apher Sci, 2014 Jan 08
Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vein occlusion in Tunisian patients.
J Matern Fetal Neonatal Med, 2015 Jul 02
Thrombophilic genes alterations as risk factor for recurrent pregnancy loss.
Clin Neurol Neurosurg, 2013 Mar 21
Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.
J Hum Genet, 2006 Feb 18
MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers.
Circulation, 2009-03-31
Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial.
The New England journal of medicine, 2012-05-17
Warfarin and aspirin in patients with heart failure and sinus rhythm.
Cerebrovascular diseases (Basel, Switzerland), 2014
Recurrent stroke in the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial.
The New England journal of medicine, 2018-10-04
Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.
JAMA Neurol,
Left Ventricular Dysfunction Among Patients With Embolic Stroke of Undetermined Source and the Effect of Rivaroxaban vs Aspirin: A Subgroup Analysis of the NAVIGATE ESUS Randomized Clinical Trial.
JAMA Neurol,
The Dilemma of Diagnosing Idiopathic Intracranial Hypertension Without Papilledema in Patients With Chronic Migraine.
JAMA Neurol,
Prevalence of Incidentally Detected Signs of Intracranial Hypertension on Magnetic Resonance Imaging and Their Association With Papilledema.
Arch Neurol,
Dopamine agonist withdrawal syndrome in Parkinson disease.
J Immunol Methods, 2016 Feb 18
Testing for myositis specific autoantibodies: Comparison between line blot and immunoprecipitation assays in 57 myositis sera.
Neurology, 2018-10-09
Antiepileptic drug treatment after an unprovoked first seizure: A decision analysis.
Arthritis and rheumatism, 2007-07
Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals.
Stroke, 2014-07
Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
Cochrane Database Syst Rev, 2020 Oct 12
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
Archives of internal medicine, 1997-10-13
A retrospective review of 61 patients with antiphospholipid syndrome. Analysis of factors influencing recurrent thrombosis.
Lupus, 2011-02
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies.
Annals of the rheumatic diseases, 2019-10
EULAR recommendations for the management of antiphospholipid syndrome in adults.
,
Diagnosis and Management of the Antiphospholipid Syndrome.
Lupus,
16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends.
J Autoimmun, 2018 Feb 13
The treatment of anti-phospholipid syndrome: A comprehensive clinical approach.
Int J Med Sci, 2009 Dec 05
Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome.
Clin Microbiol Infect, 2018 Feb 07
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).
Arthritis & rheumatology (Hoboken, N.J.), 2018-03
The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.
Journal of immunotherapy (Hagerstown, Md. : 1997), 2018-05
PD-1 Inhibitor-associated Myopathies: Emerging Immune-mediated Myopathies.
Neurology, 2019 Mar 08
Neuromuscular adverse events associated with anti-PD-1 monoclonal antibodies: Systematic review.
Front Immunol, 2022 Aug 22
Neuromuscular junction dysfunctions due to immune checkpoint inhibitors therapy: An analysis of FAERS data in the past 15 years.
Clinical pharmacokinetics, 2018-12
Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease.
Frontiers in immunology, 2018
Reversing Autoimmunity Combination of Rituximab and Intravenous Immunoglobulin.
Clinical immunology (Orlando, Fla.), 2020 Jul 15
The potential impact of timing of IVIG administration on the efficacy of rituximab for immune tolerance induction for patients with Pompe disease.
The Pediatric infectious disease journal, 2018 Oct
Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017 Nov 03
Successful IVIG treatment without discontinuation of TNF-α blocker in Guillain-Barre syndrome induced by adalimumab in patient with Crohn's disease.
BMC Res Notes, 2018 Mar 14
Tongue fasciculations with denervation pattern in osmotic demyelination syndrome: a case report of diagnostic dilemma.
Ann Indian Acad Neurol, 2018 Jul-Sep
Clinical Mimickers of Amyotrophic Lateral Sclerosis-Conditions We Cannot Afford to Miss.
Neurol Int, 2014 Aug 08
Another Perspective on Fasciculations: When is it not Caused by the Classic form of Amyotrophic Lateral Sclerosis or Progressive Spinal Atrophy?
Clinical neuropharmacology, 2010
Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects.
Current treatment options in gastroenterology, 2018-12
Parkinson's Disease and Current Treatments for Its Gastrointestinal Neurogastromotility Effects.
Clin Drug Investig, 2016 Feb
Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.
Parkinsonism Relat Disord, 2016 Mar 04
Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson's disease: Systematic review and meta-analysis.
The New England journal of medicine, 2018-02-15
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism.
N Engl J Med, 2020 Mar 29
Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer.
N Engl J Med, 2003 Jul 10
Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
N Engl J Med, 2005 Mar 31
Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.
Neurology, 2017-01-24
Relationship between risk factor control and vascular events in the SAMMPRIS trial.
Anesth Pain Med (Seoul), 2022 Jan 18
Recent update on epidural blood patch.
J Clin Med, 2020 Mar 10
Cerebral and Splanchnic Vein Thrombosis: Advances, Challenges, and Unanswered Questions.
Hematology Am Soc Hematol Educ Program, 2021 Dec 10
Clots in unusual places: lots of stress, limited data, critical decisions.
JAMA Neurol, 2019 Dec 01
Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis: A Randomized Clinical Trial.
Neurology, 2021 Mar 25
Intravenous Immunoglobulin Therapy in Patients With Painful Idiopathic Small Fiber Neuropathy.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2024 Feb 04
Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND).
Cleveland Clinic journal of medicine, 2016-01
Approach to asymptomatic creatine kinase elevation.
The British journal of dermatology, 2019-11
Utilization patterns and performance of commercial myositis autoantibody panels in routine clinical practice.
J Am Acad Dermatol, 2020 Sep 04
Accuracy of commercial panels to evaluate myositis autoantibodies: A single-institution perspective.
Rheumatology (Oxford),
The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity.
Medicine (Baltimore), 2016 Aug
Creatine kinase in the U.S. population: Impact of demographics, comorbidities, and body composition on the normal range.
BMJ, 2021 Jun 23
Investigating raised creatine kinase.
Arthritis and rheumatism, 2010-05
Assessment of cognitive function in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis by computerized neuropsychological tests.
Ann Clin Transl Neurol, 2020 Jul 06
Cognitive impairment in patients with Neuro-Sjögren.
Lupus, 2023 Apr 10
In-person versus virtual administration of the American College of Rheumatology gold standard cognitive battery in systemic lupus erythematosus: Are they interchangeable?
Lupus Sci Med, 2022 Jan
To treat or not to treat with immunosuppressive therapy: psychiatric disorders in patients with systemic lupus erythematosus.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2021 Oct 14
Validity of ICD-10 Codes for Cerebral Venous Thrombosis Depends on Clinical Context.
N Engl J Med, 2022 Oct 06
Trial of Intravenous Immune Globulin in Dermatomyositis.
Rheumatology (Oxford, England), 2015-03
Large-vessel giant cell arteritis: a cohort study.
Circulation, 2020 May 21
The COMPASS Trial: Net Clinical Benefit of Low-Dose Rivaroxaban Plus Aspirin as Compared With Aspirin in Patients With Chronic Vascular Disease.
Journal of vascular surgery, 2016 Sep
Reporting standards of the Society for Vascular Surgery for thoracic outlet syndrome.
Journal of the peripheral nervous system : JPNS, 2020 Jan 29
Backpack palsy and other brachial plexus neuropathies in the military population.
General thoracic and cardiovascular surgery, 2022 Jul 25
Brachial plexus injury and upper rib fracture after median sternotomy in cardiac surgery.
Interactive cardiovascular and thoracic surgery, 2007 Jan 04
Brachial plexus injury following median sternotomy.
Parkinsonism & related disorders, 2012 Jan
Essential tremor: phenotypes.
Neurology, 2022 Feb 10
Teaching Video NeuroImage: Tongue Tremor as a Presenting Feature of Progressive Supranuclear Palsy.
Movement disorders clinical practice, 2022 Dec 20
Isolated Jaw and Tongue Tremor in a Definite Case of Progressive Supranuclear Palsy.
British journal of haematology, 2024 Sep 02
Measurement of heparin, direct oral anti-coagulants and other non-coumarin anti-coagulants and their effects on haemostasis assays: A British Society for Haematology Guideline.
Open access rheumatology : research and reviews, 2016
Polymyalgia rheumatica: observations of disease evolution without corticosteroid treatment.
Medicine, 2016 Feb
Description and Validation of Histological Patterns and Proposal of a Dynamic Model of Inflammatory Infiltration in Giant-cell Arteritis.
Histopathology, 2023 Aug 08
Age-related histopathological findings in temporal arteries.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 2023 Sep 06
Consensus statement on the processing, interpretation and reporting of temporal artery biopsy for arteritis.
Lancet (London, England), 2018-08-04
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials.
Journal of pain research, 2017 Jan 27
Rational dosing of gabapentin and pregabalin in chronic kidney disease.
Headache, 2015 Apr 22
Headache, cerebral aneurysms, and the use of triptans and ergot derivatives.
JAMA neurology, 2018-12-01
Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group.
Journal of neuroimmunology, 2022 Apr 09
Peripheral neuropathy in sarcoidosis.
Neurology(R) neuroimmunology & neuroinflammation, 2021 Oct 04
Neurosarcoidosis: Pathophysiology, Diagnosis, and Treatment.
Lung, 2015 Nov 13
Diagnostic Utility of Angiotensin-Converting Enzyme in Sarcoidosis: A Population-Based Study.
Biomolecules, 2022 Sep 30
Performance of Serum Angiotensin-Converting Enzyme in Diagnosing Sarcoidosis and Predicting the Active Status of Sarcoidosis: A Meta-Analysis.
Archives of neurology, 2004 May
The aura-headache connection in migraine: a historical analysis.
Critical reviews in clinical laboratory sciences, 2022 Mar 11
Oligoclonal bands: clinical utility and interpretation cues.
JAMA neurology, 2018-12-01
Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial.
Stroke, 2015 Nov 03
Modafinil May Alleviate Poststroke Fatigue: A Randomized, Placebo-Controlled, Double-Blinded Trial.
Stroke, 2017 Apr 12
MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.
Stroke, 2005 Dec 01
Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010-12
A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS.
Journal of neurology, neurosurgery, and psychiatry, 2020 Jun 23
Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study.
Journal of neurology, 2023 Jun 28
The safety and effectiveness of high-calorie therapy for treating amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Annals of neurology, 2020 Jan 06
Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis.
Lancet (London, England), 2014-06-14
Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial.
Therapeutic drug monitoring, 2022 Jun 01
Drug-Drug Interactions Between Mycophenolic Acid and Proton Pump Inhibitors: A Systematic Review and Meta-Analysis.
Stroke, 2019-04
WEAVE Trial: Final Results in 152 On-Label Patients.
Sleep, 2007-06
Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning.
Seminars in neurology, 2008-04
The evaluation of chronic axonal polyneuropathies.
Seminars in neurology, 2019 Oct 22
Laboratory Evaluation of Peripheral Neuropathy.
Stroke, 2024 Feb 09
Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study.
JAMA neurology, 2019 Jun 01
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
The Lancet. Neurology, 2021 Mar 23
Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial.
Stroke, 2024 Feb 01
Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association.
Neurology, 2001-07-24
Postural change of forced vital capacity predicts some respiratory symptoms in ALS.
The European respiratory journal, 2019-06
ERS statement on respiratory muscle testing at rest and during exercise.
The journal of prevention of Alzheimer's disease, 2023
Lecanemab: Appropriate Use Recommendations.
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