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General Internal Medicine

Hematology   

Questions discussed in this category

How would you approach the staging and treatment of extranodal marginal zone lymphoma of left and right lacrimal gland?
1 Answer available
Is there any benefit to checking serum viscosity in patients with autoimmune disease and headaches/migraines to see if aspirin or clopidogrel may be beneficial?
SLE, APLS, Sjogrens, and RA can sometimes have associated serum hyperviscosity. Is the standard viscosity test sensitive enough for these conditions a...
1 Answer available
How would you treat ESRD patients on hemodialysis with recurrent AV fistula thrombosis found with low protein C activity?
For ESRD patients with decreased Protein C activity level, the purported etiology may be a dialyzable substance in uremic plasma that interferes with ...
1 Answer available
How frequently would you consider IV iron treatment for ongoing iron loss and severe iron deficiency anemia?
For example, in a patient with ongoing GI bleeding already on monthly IV iron dextran 1000 mg, would you consider dosing more frequently at Q2 or Q3 w...
1 Answer available
How do you manage patients desiring home hospice but with severe thrombocytopenia and/or anemia due to advanced malignancy?
Do you consider supportive transfusions, and if so, have you been successful with keeping patients on hospice while receiving transfusions? Do you us...
2 Answers available
How would you manage recurrent migratory lower extremity thrombophlebitis that occurs despite being on therapeutic apixaban?
No DVT. AC started due to extensive size of initial LLE SVT, with continued SVT of contralateral RLE despite therapeutic anticoagulation with apixaban...
1 Answer available
How do you approach a patient with high titer ANA and a new diagnosis of ITP, but no other signs or symptoms suggestive of active rheumatologic disease?
Patient with +ANA 1:2560 for >10 years; rest of serologies are negative. Complements are normal. Negative dsDNA. Antiphospholipid labs are negative...
5 Answers available
How long would you continue chronic transfusion therapy for adult sickle cell patients who have had a stroke?
Is treatment indefinite or do you consider discontinuing chronic transfusions at some threshold?
2 Answers available
In a patient with cryptogenic stroke while on antecedent aspirin 81 mg, how do you decide between single antiplatelet therapy, dual antiplatelet therapy, or antiplatelet agent combined with anticoagulation such as rivaroxaban 2.5 mg BID?
1 Answer available
What is your clinical threshold for treating a potential monoclonal gammopathy of thrombotic significance?
New data suggests monoclonal gammopathies can be associated with thrombotic events. Is your practice changing to include monoclonal gammopathy evaluat...
1 Answer available
What is the optimal antithrombotic management, if at all, in patients with incidentally identified findings of multiple silent embolic appearing cerebral infarcts?
3 Answers available
Should you consider thromboprophylaxis, even for low-dose lenalidomide maintenance, post-autologous transplantation?
1 Answer available
Is there any evidence for amyloid/amyloidosis causing a spurious/false PSA reading?
1 Answer available
What is the utility of a hypercoagulability workup in recurrent cryptogenic stroke, and what specific tests would you recommend?
Is there any utility in predominantly venous hypercoagulability labs?
7 Answers available
Would you consider using DOACs as a bridge to warfarin instead of heparin or LMWH?
For example, would you consider this method in an ESRD/HD patient with antiphospholipid syndrome who had a major bleed requiring reversal of warfarin ...
4 Answers available
How do you manage anticoagulation in a patient with DVT from likely malignant mechanical obstruction?
Patient has bilateral common, internal, and external iliac and femoral DVT from obstruction by a large uterine mass that is likely malignant and is pl...
1 Answer available
Can anti-cardiolipin or anti-beta-2 glycoprotein antibodies cause prolonged PTT in the absence of a lupus anticoagulant?
Labs with normal PT, but prolonged PTT (47 sec, ULN 40 sec) that does not correct on immediate mix. Lupus anticoagulant negative (DRVVT and hexagonal ...
1 Answer available
How does your approach to subsegmental PE differ from segmental PE both diagnostically and therapeutically?
3 Answers available
Can lupus anticoagulant be positive despite a normal aPTT?
How often does this occur and does this lower your suspicion for a "true" or clinically significant lupus anticoagulant?
1 Answer available
What parameters would you use to monitor and interpret iron levels in a hemochromatosis patient where ferritin is unreliable due to underlying chronic inflammation?
How would your recommendation change if the patient has H63 homozygous mutation?
2 Answers available
How do you approach the work-up for a patient with iron deficiency anemia who is not responding to oral iron therapy?
Presuming good medication adherence.
1 Answer available
Are there data to support full-dose anticoagulation added to an antiplatelet in recurrent peripheral arterial thrombosis requiring revascularization and stenting? 
Assume the patient does not have another indication for AC like VTE or AFib. Could this be suggestive of a hypercoagulable state?
2 Answers available
Is there a role for DOAC use for patients with unprovoked PE, that have had recent sleeve gastrectomy with duodenal bypass?
Or do you generally prefer warfarin/non-DOAC agents? Do you consider trialing DOACs and testing anti-Xa DOAC levels to assess for absorption?
1 Answer available
How would you manage elevated vWF and FVIII levels in a patient with a family history of coagulopathy?
vWF and FVIII activities ~200% and were checked because of the patient's family history of "coagulopathy". Is there any utility in repeating the test...
1 Answer available
How do you approach severe anemia and thrombocytopenia in an elderly patient whose bone marrow biopsy shows hypercellular marrow with mild dysplasia in erythroid and megakaryocytic lineage but normal cytogenetics and a negative NGS panel?
Hgb is 8 and platelets 10. A very small PNH clone (0.08%) detected. No evidence of hemolysis. No response to steroids. All other anemia/thrombocytopen...
1 Answer available
How do you interpret CSF pleocytosis in the context of significant leukocytosis on CBC?
For example, a patient with 100 WBCs in CSF with a peripheral WBC 43k/mm3 due to AML.
1 Answer available
How does one interpret an SPEP showing potentially obscured but non-quantifiable M-spike however an IFE showing monoclonal protein?
Can you elaborate on reasons for a non-quantifiable SPEP and how does one follow the paraprotein?
3 Answers available
Do you routinely consider FDG PET/CT imaging for workup of fever of unknown origin?
1 Answer available
How do you evaluate a patient with MGUS and peripheral neuropathy?
Can you explain when would you consider light chain amyloidosis work up with fat pad biopsy?
1 Answer available
How do you approach management for CCUS with severe cytopenias?
Bone marrow biopsy does not meet criteria for MDS and no other identifiable cause of the cytopenias.
1 Answer available
Would you evaluate for thrombophilia in patients with incidental splenic infarcts in the setting of known cirrhosis, portal hypertension, and splenomegaly?
How would you approach anticoagulation in this situation? Does the presence of thrombocytopenia or hemorrhagic splenic infarcts change your manag...
1 Answer available
Would you anticoagulate an SMV thrombosis caused by malignant obstruction in the setting of metastatic colorectal cancer?
For what duration and is there a preferred anticoagulation agent?
1 Answer available
Would you start anticoagulation in a patient with RCC and related (tumor) thrombus with extension to renal vein and further?
3 Answers available
How do you counsel patients who experience diarrhea from mycophenolate mofetil (Cellcept)?
Do you generally recommend anti-diarrheals, dietary modifications, or consider this an unacceptable side effect and move to other therapies? 
2 Answers available
How do you manage significant asymptomatic indirect hyperbilirubinemia in patients with hemolytic diseases (SCD, HS, etc.)?
Do you consider starting Ursodiol? Do you perform routine abdominal ultrasound to monitor for cholelithiasis?
1 Answer available
For patients with SLE, is there an ANC level for which you would hold or adjust hydroxychloroquine in an asymptomatic patient?
UpToDate recommends Hydroxychloroquine for all SLE patients, but neutropenia is sometimes ascribed to HCQ rather than the underlying disease. What lev...
2 Answers available
What parasites do you screen for in your workup of HES?
1 Answer available
When would you consider using G-CSF in patients with rheumatic disease who have received cyclophosphamide?
2 Answers available
Can TPO agonists, like avatrombopag or lusutrombopag, be used for patients with chronic thrombocytopenia and new acute portal vein thrombosis?
Do the presence of gastric varices and use of anticoagulation change the way you think about using these agents?
1 Answer available
How would you approach secondary stroke prevention in an adult with Hemoglobin SC disease?
Would you consider chronic RBC exchange versus HU?
1 Answer available
What is your approach to DVT prophylaxis in patients who require IVIG but are at increased risk for thrombotic events?
E.g., a patient with newly diagnosed CIDP who is wheelchair-bound.
2 Answers available
How would you approach post-operative VTE prophylaxis for renal transplant in patients with a prior history of provoked VTE?
Are there specific guidelines for managing this patient population?
1 Answer available
How would you manage a patient with morbid obesity who presents with new symptomatic pulmonary embolism a few days after he was started on DOAC for DVT?
What is your preferred anticoagulation in patients with BMI >50?
5 Answers available
Does aspirin dose (81 mg vs 325 mg) matter for secondary stroke prevention?
Should some patients get 325 mg instead of 81mg at least for a certain amount of time, such as patients in the acute phase of ischemic stroke or patie...
1 Answer available
What workup do you perform for elevated B12 levels in an adult who is not taking supplements?
For B12 levels >2000-4000.
1 Answer available
Is there any indication for hydroxyurea in patients with sickle cell trait?
2 Answers available
How would you approach pursuing a kidney biopsy in a patient with suspected lupus nephritis who is on warfarin for antiphospholipid antibody syndrome? 
2 Answers available
How do you manage arthritis resulting from deferiprone in transfusion dependent thalassemia?
1 Answer available
Does your evaluation of a young person with spontaneous upper extremity DVT vary as compared to lower extremity DVT?
Do you do additional workup for venous obstruction or any other different testing/evaluation?
1 Answer available
Do you use direct oral anticoagulants to treat port-a-cath related VTE in patients with an active malignancy?
Do social or economic factors (i.e., relative cost of acquiring LMWH, the patient being injection averse) affect your decision to use DOACs? Do you s...
1 Answer available
Do you favor 24 hour urinary metabolites over random urine collection when screening for MCAS?
1 Answer available
How do you manage hyperalgesia in patients with sickle cell disease?
1 Answer available
Do you diagnose MCAS if a patient is concurrently on drugs known to cause non-specific mast cell degranulation?
1 Answer available
Is it true that a ferritin above 200 essentially rules out iron deficiency?
Does this hold true when the patient has significant inflammation? 
1 Answer available
When would you phlebotomize patients with secondary hemochromatosis, such as due to NAFLD/cirrhosis?
HFE gene mutations in C282Y and H63D are negative.
1 Answer available
How do you utilize cytokine panels in your clinical practice?
Is there utility when classic inflammatory markers (ESR,CRP) or disease specific markers (C3, C4, dsDNA) do not correlate with patients disease activi...
1 Answer available
What is the preferred approach to managing non-occlusive or partially occlusive venous sinus thrombosis?
1 Answer available
Do you avoid ESAs in patients with anemia and chronic kidney disease who also have Factor V Leiden?
1 Answer available
How do you approach evaluation for underlying rheumatologic disease in patients with chronic asymptomatic thrombocytopenia?
Thrombocytopenia is moderate (80-100,000 microL). No concomitant cytopenias present.
2 Answers available
For patients with suspected complement-mediated TMA, are there specific clinical or laboratory parameters that can help guide the decision for starting empirical treatment (e.g., eculizumab) while awaiting the results of complement testing?
1 Answer available
When would you initiate chronic therapeutic phlebotomy in a patient with erythrocytosis secondary to a high hemoglobin-oxygen affinity hemoglobinopathy?
1 Answer available
How would you work up a patient with cutaneous mastocytosis?
Is a BM biopsy a must when there is skin involvement? If tryptase level is mildly elevated but less than 20 would you recommend a BM biopsy?
1 Answer available
How would you manage a patient pre-operatively with a prolonged PTT that does not correct on mixing, with lupus anticoagulant testing that is abnormal by LA-PTT only?
Confirmatory tests with DRVVT, hexagonal phase assay, and PNP are all normal. No bleeding history
1 Answer available
What is the indication for phlebotomy in compound heterozygous hemochromatosis?
What is the ferritin target that you would aim for? What would be your approach for a ferritin >500? When do you order an MRI liver for iron quanti...
1 Answer available
Do you typically use NOACs or Lovenox in patients with stroke due to hypercoagulability from malignancy?
1 Answer available
When do you re-image patients with a diagnosis of venous sinus thrombosis?
2 Answers available
Is there a role for phlebotomy in secondary polycythemia?
Aside from addressing the underlying case, is there a role for phlebotomy in secondary polycythemia such as in COPD or post-renal transplant erythrocy...
1 Answer available
Does PT/PTT elevation due to severe vitamin K deficiency protect against thrombosis?
In the setting of requiring anticoagulation for atrial fibrillation and bioprosthetic valve, but also having severe vitamin K deficiency, would you st...
2 Answers available
Is a bone marrow necessary in patient with splenomegaly and polycythemia vera?
1 Answer available
How do you discuss harms of MGUS screening with other medical providers?
For example, how do you address tendency to "over-order" these tests in patients with common aches/pains but no structural abnormalities on advanced i...
2 Answers available
Do you utilize post-vaccination IgG titers to detect common variable immunodeficiency in patients who are about to start or are actively on B cell depleting therapy?
2 Answers available
What are your management strategies for patients with chronic kidney disease attributed to deferasirox use who require frequent blood products for a hematologic disorder?
1 Answer available
How would you manage an elderly patient with mild pancytopenia who refuses bone marrow biopsy and whose flow cytometry is suggestive of CMML/MDS?
2 Answers available
How would you manage a young patient with HL who develops HF (EF < 30%) after 4 cycles of A+AVD who obtained a PET2 CR?
2 Answers available
What additional testing is recommended with heterozygous HFE C282Y mutation whose ferritin is elevated and transferrin saturation percentage is at baseline?
Ferritin >2200, TSAT >80%
2 Answers available
What is your preferred formulation of parenteral iron?
There are various formulations of intravenous iron; each with varying costs, test dose requirement, elemental dose, and number or time of infusions ne...
1 Answer available
Do you use FVIII levels to differentiate between DIC and coagulopathy of liver disease?
Common thought is that FVIII may be used for differentiating coagulopathy in liver disease (normal to increased, from reduced clearance of VWF/FVIII) ...
4 Answers available
Does phosphatidylserine antibody play a role in the diagnosis of antiphospholipid antibody syndrome?
3 Answers available
How do you approach anticoagulation in the setting of HIT and thrombocytopenia?
I.e. platelet count <30. Would your management change if HIT were only suspected rather than confirmed?  
1 Answer available
Do you avoid ESA use in patients with anemia and chronic kidney disease who also have APLS and risk for thrombosis?
2 Answers available
Are there any possible scenarios where you would do phlebotomies for heterozygous hemochromatosis?
1 Answer available
How long do you anticoagulate for cirrhosis patients who have portal vein thrombosis extending to the mesenteric veins?
2 Answers available
How do you dose apixaban in patients with CrCl <30 mL/minute?
1 Answer available
For an asymptomatic patient discovered during workup for elevated PT/PTT to have mild prothrombin deficiency, would you suggest any preoperative prophylaxis?
Level >60%. No family or surgical h/o of bleeding but heavy postpartum bleeding.
2 Answers available
Would you treat a hemochromatosis carrier with IV iron if they have iron deficiency anemia in conjunction with elevated ferritin?
Hb <11, low iron saturation (<10%), high ferritin (>900), and low reticulocyte hemoglobin equivalent.
1 Answer available
How should one approach an incidentally found T-cell gene arrangement?
Work-up was performed for isolated anemia which resolved to >11 g/dl after the reversible cause was treated.
1 Answer available
In a patient with a history of HIT, how would you reintroduce Heparin?
Is it only done when heparin is used in an emergency?
1 Answer available
What is your approach to evaluation in patients who present with erythromelalgia?
1 Answer available
How do you manage drug-drug interactions between oral anticoagulants and the ARSI agents such as apalutamide and enzalutamide?
1 Answer available
What is your approach to using medications that can cause bone marrow suppression in SLE patients who have persistent leukopenia?
3 Answers available
Would you anticoagulate a patient with splenic infarctions in the setting of CMV viremia?
If so, for how long? 
1 Answer available
What are the indications for anticoagulation in splenic infarctions?
What is the work up and what is the duration of anticoagulation if used?
2 Answers available
How do you interpret a low VWF activity/antigen ratio, when both activity and antigen levels are above 50%?
E.g. Normal F8, VWF activity ~50%, VWF antigen ~100%, ratio 0.5 sent in a patient with positive bleeding history Is there any clinical significance t...
1 Answer available
What is your approach to bridging anticoagulation in patients with history of recent HIT?
Do you always avoid heparin/enoxaparin or rechallenge if antibodies are negative?
1 Answer available
What is the ideal period to wait until curative surgery for patients with acute pulmonary embolism and solid malignancy?
Specifically, asymptomatic subsegmental PE diagnosed within a month from planned bilateral mastectomy for breast cancer. 
1 Answer available
How would approach the management of a patient with significantly positive anticardiolopin and beta 2 glycoprotein antibodies in the absence of any clotting (including obstetric) history but with significant thrombocytopenia (but no other features of active connective tissue disease)?
1 Answer available
How do you manage a DOAC if interested in testing for lupus anticoagulant?
Significant history of autoimmune diseases and DVT in family, recent PE/DVT for a month
4 Answers available
How would you manage a patient with new renal failure and mild anemia in the setting of a moderate M-Spike and low kappa/lambda ratio, but with negative PET and bone marrow with <10% plasma cells?
1 Answer available
What initial workup do you perform when there is a concern for porphyria?
1 Answer available
Can you use apixaban or rivaroxaban in case of dabigatran failure?
1 Answer available
How do you approach a persistently elevated mean platelet volume and immature platelet fraction in an otherwise healthy patient with a normal platelet count?
Provided that the platelet count is normal, do you usually consider this to be a potential erroneous result or do you pursue additional workup for RBC...
1 Answer available
Is there a correlation between spleen size and degree of thrombocytopenia?
1 Answer available
How would you manage warfarin in a patient with APLS and alcoholic cirrhosis?
Nonreliable INR, given hepatic coagulopathy
1 Answer available
How would you approach microcytosis without anemia with high TSAT and ferritin?
How often do you see non transfusion-dependent thalassemia and how do you approach the treatment?
1 Answer available
How is transferrin saturation a reliable indicator for any parameter if serum iron is not reliable?
Although TIBC is negative acute phase reactant, would it be a better indicator of iron deficiency (in combination with ferritin)?
1 Answer available
What are common indications for ordering NGS of peripheral blood?
Would a negative NGS eliminate the possibility of MDS? Is bone marrow biopsy indicated in a patient with pancytopenia with a negative NGS panel?
1 Answer available
How accurate of an indicator is reticulocyte hemoglobin equivalent for iron deficiency?
1 Answer available
What is your practice for work up and treatment of incidental splenic infarcts with or without splenomegaly in patients without sickle cell disease?
1 Answer available
For patients with microcytosis MCV 75-79 and normal Hb, low TIBC, and normal ferritin do you always rule out thalassemia?
What else would you consider in your differential?
5 Answers available
In antiphospholipid syndrome with recurrent strokes, would you consider adding antiplatelets to warfarin?
Also how would you manage this perioperatively?
7 Answers available
How do you manage recurrent hemodialysis filter clotting in an in-center ESKD patient with heparin-induced thrombocytopenia?
1 Answer available
Would testing for ATTR cardiac amyloidosis be considered in an older patient with bilateral carpal tunnel surgeries and multiple spinal stenosis surgeries, but no obvious cardiac symptoms?
1 Answer available
How would you work up an elevated copper level without cytopenias in a patient with history of bariatric surgery not on supplements or using copper utensils?
Often see bariatric surgery ordering these tests, is there any clinical relevance?
1 Answer available
What is your approach to evaluating a patient with known rheumatologic disease and elevated free kappa:lambda ratio, but no evidence of monoclonal immunoglobulins?
1 Answer available
When should I consider anticoagulation in an unprovoked upper extremity superficial venous thrombosis?
Would it change your management if the thrombus was symptomatic? Or if larger >3 cm?
1 Answer available
Do the level of positive lupus anticoagulant titers correlate with the risk of VTE?
1 Answer available
What is your approach to further work-up and management of neutropenia in patients with SLE/RA overlap?
For example, a patient with a bone marrow biopsy that shows normocellular bone marrow. Prior management with leflunomide and HCQ with neutropenia attr...
2 Answers available
What would be the main indications for opting for biosimilars over an original biologic, outside of insurance barriers?
Are there any instances where you would prefer a biosimilar rather than the reference product? 
2 Answers available
What additional testing besides LAC/APLS, factor V Leiden, prothrombin gene mutation, JAK 2 do you draw for unprovoked cerebral venous sinus thrombosis?
1 Answer available
What would be your next step in workup for a patient with IgG Kappa Monoclonal protein detected on SPEP and free lambda light chains found in the urine, with chronic diarrhea for 3 years and concern for GI amyloidosis?
1 Answer available
How do you approach the workup for a patient with persistently elevated inflammatory markers (CRP and ESR) whose history and exam do not point to a clear cause?
4 Answers available
What is the best approach to manage iron overload secondary to both heterozygous HFE gene mutation and two heterozygous aceruloplasminemia gene mutations?
Any particular labs or imaging indicated?
1 Answer available
What are your recommendations for adult sickle cell patients who end up being admitted several times a year for pain crises despite hydroxyurea, crizanlizumab, voxelotor, etc?
What can you recommend that might help keep them out of the hospital? Do you consider a program of exchange transfusions in this situation?
2 Answers available
How do you explain TTP to patients?
1 Answer available
Would you anticoagulate a patient with an asymptomatic gonadal vein thrombosis on CT scan, found on surveillance imaging for colorectal cancer?
1 Answer available
Is there a role for hydroxychloroquine for secondary prevention in patients with APS without SLE?
1 Answer available
Do you recommend starting an antiplatelet for primary prophylaxis in post splenectomy thrombocytosis given there is some increased risk of venous thrombosis?
If so, what platelet count threshold would you use? Would age impact your decision? Would you do a bone marrow to rule out primary MPD in adults if th...
1 Answer available
How do you approach low to moderate titer of APLS when working up unprovoked DVT if it is persistent on repeat testing?
4 Answers available
Would you consider using DOACs in a young patient with SLE and Libman-Sacks endocarditis, who is negative for APS?
2 Answers available
How do you manage a patient with progressive cerebellar ataxia and positive cardiolipin antibodies?
Do you wait 12 weeks for confirmation to begin treatment if patient is declining?
1 Answer available
How should elevated PT of unclear etiology and significance be evaluated?
In the absence of concerning bleeding or thrombosis, family history of coagulopathy, current anticoagulant use, or malnutrition
2 Answers available
How would you counsel a patient with active SLE on treatment, low to moderate level of one of the APLS antibodies, and remote history of provoked blood clot regarding perioperative anticoagulation?
Is SLE-related APLS managed differently in terms of anticoagulation?
2 Answers available
Do you send an antiphospholipid antibody panel routinely for all patients with an unprovoked thrombus?
2 Answers available
Is rituximab for refractory ITP contraindicated in the setting of an active COVID infection, particularly in a patient with asymptomatic COVID?
2 Answers available
How will you treat a young man with recurrent cryptogenic strokes with no identifiable cause, with MTHFR A1298C homozygous mutation and normal homocysteine level?
1 Answer available
For hypogammaglobulinemia as a complication of successful treatment, do you empirically start prophylaxis with either 400 mg/kg monthly for IVIG or 100 mg/kg weekly for subcutaneous immune globulin?
1 Answer available
Would you consider clearing a patient with essential thrombocytosis for a kidney donation?
1 Answer available
How would you work up a mildly neutropenic patient (ANC >800) with family history of neutropenia and personal history of occasional mouth sore?
What are indications to order gene mutation studies (e.g. ELANE) and how would it help the patient?
1 Answer available
What is the appropriate management of arthralgias associated with bosutinib?
1 Answer available
How do you work up a young patient with increasing ferritin and normal TSAT without infectious, inflammatory, or liver disorders?
Ferritin uptrending >1000, no additional lab abnormalities. HFE wildtype. Too young for age-appropriate cancer screening. Asymptomatic except fatig...
1 Answer available
What is the optimal management of a patient needing surgical clearance for a knee replacement with VWF Ag and factor VIII between 40-50 and no bleeding history?
1 Answer available
In a patient with Type I von Willebrand disease with history of VTE and heavy menses, would tranexamic acid be a treatment option?
Is thrombotic risk too significant? Patient failed OCPs.
3 Answers available
When can abdominal surgery be safely performed for presumptive ovarian cancer in a patient with recent pulmonary emboli?
(Normal oxygenation and echo)
1 Answer available
Can APLS cause a false positive HIT ELISA?
If so, is there one type of antibody that is more likely to cause this false positive test? 
1 Answer available
At what ferritin threshold would a patient with anemia of inflammation or malignancy no longer benefit from iron supplementation for functional iron deficiency?
For example, if TSAT is less than 20% but ferritin is over 200. 
1 Answer available
How do you workup splenomegaly related to possible hematologic etiology in the absence of abnormal blood counts, adenopathy or severe constitutional symptoms?
For instance, evaluation by primary care and GI without other etiology for splenomegaly
1 Answer available
Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?
Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?
3 Answers available
How would you confirm the diagnosis of splenic marginal zone lymphoma without utilizing splenic biopsy or splenectomy?
1 Answer available
Do you treat secondary erythrocytosis caused by SGLT2 inhibitor?
1 Answer available
How do you approach work-up for a patient suspected for monoclonal gammopathy of renal significance for whom renal biopsy is contraindicated?
E.g. a patient with monoclonal protein with mild light chain ratio elevation. Do we need to get a BM biopsy in all such patients?
2 Answers available
When considering the use of DOACs in APLS, does the number of positive APLS antibodies influence your decision?
2 Answers available
How do you manage and/or prevent ruxolitinib withdrawal syndrome?
1 Answer available
Do you hold IV iron in the setting of active infection?
1 Answer available
What is the recommended management approach in regard to diagnostic evaluation and treatment for patients with homocystinuria and cerebral thrombosis?
Do we prophylactically place patients on anticoagulation after one episode? Besides MRI/MRV brain, are there other diagnostic imaging that should b...
1 Answer available
What workup and initial treatment should be considered for suspected autoimmune myelofibrosis?
1 Answer available
How would you work up and manage persistent lymphopenia in an asymptomatic patient?
ALC<200
1 Answer available
How would you manage an incidental catheter-related thrombosis in a functioning dialysis catheter?
- Dialysis catheter used for hemodialysis- RIJ thrombus in dialysis catheter was incidentally found- Patient asymptomatic with no prior history of VTE...
2 Answers available
Is an elevated CRP an expected finding in an otherwise healthy patient with hemoglobin S - alpha thalassemia?
CRP 39 mg/L (normal < 10) and normal ESR
1 Answer available
How would you manage someone with antithrombin deficiency who has recurrent VTE on a DOAC?
APLA syndrome, obesity, non compliance ruled out and prefers another oral anticoagulation. Is higher dose of rivaroxaban or apixaban an option?
2 Answers available
Does normal methylmalonic acid levels absolutely rule out vitamin B12 deficiency?
1 Answer available
Do you always initiate hypercoagulable work up in a patient with recurrent stroke?
If so, what would you consider ordering?
1 Answer available
In a patient with a bleeding disorder, how would one approach anticoagulation during active COVID infection?
Bleeding disorder such as vWD
1 Answer available
At what platelet count would you feel comfortable dosing aspirin 81 mg for coronary artery disease in a patient with ITP?
Presuming strong indication for ASA - eg history of NSTEMI
1 Answer available
How do you counsel patients with elevated factor VIII levels for their thrombosis risk?
Should we stop checking factor VIII levels as part of thrombosis workup?
1 Answer available
How would you approach protein S deficiency found on hypercoagulability work-up in a patient with a post-operative central retinal vein occlusion?
In the setting of no personal or family history and no other risk factors for thrombosis, is systemic anticoagulation warranted if local treatments (e...
4 Answers available
How do you interpret elevations in antiphospholipid antibodies that are lower than Sapporo criteria?
(e.g. beta 2 glycoprotein IgM > 20 but <40)
2 Answers available
Would you give antithrombin concentrate for surgical VTE prophylaxis in case of congenital AT deficiency?
1 Answer available
To what extent does the degree of thrombocytopenia correlate with the severity of cirrhosis?
1 Answer available
How do you manage patients who develop minor antigen antibodies and require multiple blood transfusions?
e.g. K, Fya, s, etc
1 Answer available
How long after starting anticoagulation would you remove an IVC filter in a patient with a DVT presenting with stroke and PFO which is now closed?
1 Answer available
What are the alternatives to anticoagulation in an individual with an atrial thrombus and absolute contraindications to anticoagulation?
1 Answer available
How does evidence of cerebral amyloid angiopathy/microbleeds affect choices for secondary stroke prevention in patients with a history of ischemic stroke and atrial fibrillation?
How do you approach secondary stroke prevention for patients with ischemic stroke, atrial fibrillation, and signs of cerebral amyloid angiopathy/micro...
1 Answer available
Would you give a TPO agonist for thrombocytopenia in alcoholic cirrhosis?
1 Answer available
Would you check vitamin B6 routinely in the work up of anemia?
1 Answer available
Are there best practices or data regarding the use of open notes among oncology patients?
What is the impact among patients and providers? Has your documentation been adjusted now that patients can readily review?
2 Answers available
How do you approach heparin management in patients who have suprathetherapeutic Xa levels on minimal heparin?
1 Answer available
What is your recommended management algorithm for bleeding associated with an acquired factor VIII inhibitor?
1 Answer available
How would you qualify and treat a patient with neutropenia, anemia, and abnormal NK cell population with normal trilineage marrow maturation?
Peripheral blood flow shows prominent NK cell population but marrow aspiration/bx shows normocellular marrow with trilineage hematopoiesis. 
1 Answer available
Does 4G/5G polymorphism in the plasminogen activator inhibitor (PAI-1) gene increase the risk of thrombosis?
In the absence of a VTE would you consider prophylaxis after a surgical procedure? Often non-hematologists order this testing but we are consulted for...
1 Answer available
Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?
Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?
1 Answer available
Is antiplatelet or anticoagulant therapy preferred for the secondary prophylaxis of cryptogenic stroke in a patient with underlying malignancy?
4 Answers available
For treatment of ITP, what would you add to dexamethasone to achieve the fastest recovery in a patient waiting for a procedure?
IVIG, TPO, or other agents?
1 Answer available
How should one manage a patient with leukocytosis and borderline detectable BCR-ABL without other clinical features of CML such as basophilia or splenomegaly?
e.g. IS < 0.002% by qPCR
1 Answer available
How does one interpret persistently positive lambda light chains on serum immunofixation but without measurable serum monoclonal protein and a normal light chains and ratio?
Is a repeatedly abnormal serum immunofixation all it takes for MGUS?
2 Answers available
What are your considerations for peri-operative anticoagulation in patients with a mechanical heart valve undergoing a major noncardiac surgery?
Please comment on bridging.
1 Answer available
Does testing for elevated serum homocysteine have any relevance in thrombophilia management?
What should be done with a high level?
1 Answer available
Are you comfortable using DOACs in obese patients with VTE?
1 Answer available
Do you approach the diagnosis and treatment of HIT patients differently in the outpatient setting or in a resource-limited community setting?
For example, for outpatients or resource-limited settings with a moderate probability 4-T score (but low clinical suspicion), would you ever consider ...
1 Answer available
How do you manage HIT in a patient with high bleeding risk?
e.g. in the setting of using prophylactic heparin in the past but now requiring therapeutic anticoagulation
1 Answer available
What is your typical workup for a patient with a spontaneous renal infarct?
Please also discuss the type and duration of anticoagulation.
1 Answer available
In patients with high-risk polycythemia vera with a history of thrombosis, should aspirin be used in addition to indefinite anticoagulation and cytoreduction for prevention of recurrent thrombosis?
What if there are no cardiovascular risk factors?  Are VKAs preferred or can DOACs be used?
1 Answer available
How do you approach patients with underlying psychiatric disorders who refuse CML treatment due to not believing their diagnosis?
1 Answer available
Do you routinely check for copper deficiency as part of workup for bicytopenia with leukopenia/anemia or pancytopenia?
1 Answer available
What is your preferred approach for patients with anti-phospholipid syndrome with recurrent thrombosis on coumadin and LMWH?
1 Answer available
How would you approach moderate neutropenia (ANC < 1000) in a solid organ transplant recipient?
Is there a particular sequence you would adjust contributing antirejection or antimicrobial medications? Is the use of G-CSF appropriate and at what c...
2 Answers available
How do you diagnose sickle hepatopathy?
1 Answer available
How do you approach conversations regarding discontinuation of transfusions in patients with advanced hematologic malignancies who are otherwise appropriate for hospice?
Are there other supportive care interventions that would otherwise be covered by hospice?
1 Answer available
How would you manage VTE in a patient with bleeding disorder such as hemophilia?
Have you used anticoagulants other than coumadin? Or is that the only appropriate agent given monitoring is based on PT/INR?
1 Answer available
How would you manage a patient with acquired von Willebrand disease who requires DAPT for arterial disease?
1 Answer available
What hematologic conditions are contraindications for a COVID vaccine?
2 Answers available
How would you manage a patient with type 1 cryoglobulinemia secondary to MGUS?
What if the patient is no longer responding to steroids?
1 Answer available
Do you recommend anticoagulation for a splenic infarct in patients with myelofibrosis and splenomegaly?
1 Answer available
How do you approach treatment of vasculitis in a sickle cell disease patient?
There are multiple difficulties that could be seen: steroids can precipitate a sickle cell crisis, vasculitis and sickle cell can produce similar clin...
1 Answer available
What is your perioperative approach to holding and restarting hydroxyurea in patients with essential thrombocythemia?
1 Answer available
Should assessing for a MTHFR mutation be part of the thrombophilia evaluation in a patient presenting with a thrombus?
1 Answer available
Can you use other iron formulations if a patient develops Stevens-Johnson Syndrome with ferumoxytol?
1 Answer available
Is there any role for iron chelation in a patient with iatrogenic transfusion-induced iron overload such as in patients with end-stage kidney or liver disease?
Does transplant eligibility make a difference for management?
1 Answer available
Do you routinely obtain bone marrow biopsy in newly diagnosed autoimmune hemolytic anemia when working up potential underlying etiologies?
1 Answer available
How do you approach evaluation of pulmonary vein thrombosis?
Is there any difference between anticoagulants in this clinical context (e.g. anti-Xa inhibitors vs warfarin vs LMWH)?
1 Answer available
How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?
Is there a role for empiric antibiotics if there is history of opportunistic infection?
1 Answer available
How do you approach the treatment of drug-induced thrombotic microangiopathy?
When do you consider initiating eculizumab?
1 Answer available
How would you evaluate a patient with an isolated high RBC count but with a normal hemoglobin and hematocrit?
Would you consider this type of patient as having polycythemia?
2 Answers available
When (if ever) do you check for anti-platelet antibodies for workup of thrombocytopenia?
1 Answer available
Do you offer iron supplementation to a patient with iron studies that are normal (including normal ferritin) except for low iron saturation?
What is the potential differential diagnoses for low iron saturation?
1 Answer available
Do you routinely start anticoagulation for a patient with newly diagnosed hepatocellular carcinoma presenting with a portal venous thrombosis?
3 Answers available
How do you approach patients with a history of lymphoma in remission who are in need of immunosuppressive (e.g. TNF blockers, 6MP) or other therapies (e.g. JAK inhibitors) for autoimmune disease that have been linked with the development of lymphoma?
1 Answer available
What could explain discordant iron studies?
For a patient with low ferritin, but high TSAT?
1 Answer available
How do you workup erythrocytosis with a normal or elevated serum erythropoietin?
2 Answers available
What are the current official guidelines regarding COVID-19 vaccination for patients with cancer or for hematologic conditions?
2 Answers available
Do you account for the effect of coffee on platelet aggregation studies?
1 Answer available
Why are autoantibodies not often detected on monoclonal gammopathy assays (SPEP/IFE, quantitiative immunoglobulins)?
For example, in cold agglutinin disease or AIHA, antibodies can be detected via DAT, but are often not observed on assays for monoclonal gammopathies.
1 Answer available
How would you time COVID-19 vaccination with someone on R-CHOP chemotherapy?
1 Answer available
Is there an equivalent test for serum viscosity in sickle cell disease?
1 Answer available
Is there a role for G-CSF treatment for SLE patients with persistent neutropenia?
1 Answer available
How do you counsel patients who are candidates for a clinical trial regarding their options?
Specifically, are there strategies you use to 1) empower patients to participate in decision-making and 2) reassure patients who may be skeptical?
2 Answers available
What is your threshold for pursuing bone marrow biopsy in a lupus patient with cytopenias?
2 Answers available
How do you approach the management of a patient with symptomatic iron deficiency anemia who is intolerant of iron?
Such as a patient who cannot tolerate oral iron and has had a anaphylaxis to intravenous iron
4 Answers available
What is the target ferritin level for patients with hereditary hemochromatosis and signs of end-organ damage?
For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?
2 Answers available
For which rituximab infusion reaction symptoms do you consider it safe to re-challenge in the office with adjusted rates and pre-medications?
1 Answer available
Should venous thrombosis in a patient with Behcet syndrome be treated with both immunosuppression and anticoagulation?
1 Answer available
How do you handle hypogammaglobulinemia detected in patients prior to maintenance rituximab infusion?
2 Answers available
Is there a role for anti-neutrophil antibody testing in the workup of neutropenia?
If autoimmune neutropenia already suspected, is this test informative or unnecessary?
1 Answer available
Do hemoglobin S levels always correlate with SCD phenotype?
What is the lowest level you have seen with uncomplicated or complicated crises?
4 Answers available
How do you approach diagnosing a patient with Iron Refractory Iron Deficiency Anemia (IRIDA)?
Do you go straight to TMPRSS2 genetic testing or what other lab testing (e.g. hepcidin) could be helpful?
1 Answer available
How do you manage VTE in the setting of persistent severe thrombocytopenia?
Is there a preferred strategy of transfusional support versus reduced-dose anticoagulation during the duration of thrombocytopenia?
3 Answers available
Is there any role for direct oral anticoagulants in the treatment of antiphospholipid syndrome?
What if this was "triple-negative" antiphospholipid syndrome?
2 Answers available
How often do you utilize soluble transferrin receptor or hepcidin testing in the diagnosis of ambiguous iron deficiency, such as with concomitant anemia of chronic disease?
Does recent iron intake affect the iron panel, and if so, do you often order fasting labs in practice?
1 Answer available
Would you anticoagulate a patient with an isolated arterial thrombosis in the setting of an inherited thrombophilia?
Does your opinion change based on the specific underlying inherited thrombophilia? The original case was a central retinal artery occlusion in a patie...
2 Answers available
How do you evaluate an isolated prolonged aPTT in patients?
Especially in a patient without hemophilia or thrombosis history?
1 Answer available
Do you routinely prescribe anticoagulation for patients on active chemotherapy?
1 Answer available
Would you consider giving ESA for anemia secondary to chronic kidney disease in a patient with follicular lymphoma in remission and on rituximab maintenance?
1 Answer available
Would you stop current immunosuppressive therapy or delay starting immunosuppressive therapy in a patient with aplastic anemia who has been infected with COVID-19?
2 Answers available
Are patients with bleeding disorders receiving plasma-derived products at increased risk of acquiring COVID-19?
1 Answer available
How do you approach a patient with IgM monoclonal gammopathy associated with severe neuropathy of unclear etiology?
2 Answers available
What stage is bilateral orbital/conjunctival NHL (limited only to the bilateral orbit/conjunctiva)?
2 Answers available
How do you approach incidentally diagnosed mantle cell lymphoma found on a routine screening colonoscopy?
1 Answer available
What is your preferred treatment to ameliorate bone pain from G-CSF?
1 Answer available
How are you making the diagnosis of chronic lymphocytic leukemia transforming to prolymphocytic leukemia?
Technically, you can have up to 55% of larger cells circulating and still be called CLL.
1 Answer available
What is the difference between involved node and involved site irradiation?
1 Answer available


Papers discussed in this category

International journal of radiation oncology, biology, physics, 2014-07-15
Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the international lymphoma radiation oncology group (ILROG).
Arch. Pathol. Lab. Med.,
A TNM-based clinical staging system of ocular adnexal lymphomas.
Int. J. Radiat. Oncol. Biol. Phys.,
Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes.
J Clin Oncol, 2020 Feb 10
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Blood,
How I treat unexplained arterial thrombosis.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2016-04
Apixaban for the Secondary Prevention of Thrombosis Among Patients With Antiphospholipid Syndrome: Study Rationale and Design (ASTRO-APS).
Blood, 2018 Jul 12
Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome.
Ann. Intern. Med., 2019 Oct 15
Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.
Blood Transfus, 2018 Oct 24
Platelet cut-off for anticoagulant therapy in thrombocytopenic patients with blood cancer and venous thromboembolism: an expert consensus.
J Thromb Haemost, 2018 May 08
Management of cancer-associated thrombosis in patients with thrombocytopenia: guidance from the SSC of the ISTH.
Chest, 1975-12
Symptomatic and puomonary response to acute phlebotomy in secondary polycythemia.
Clin Nephrol,
Therapeutic efficiency of phlebotomy in posttransplant hypertension associated with erythrocytosis.
JAMA network open, 2018-11-02
Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.
American journal of hematology, 2011-10
Safety and efficacy of rapidly administered (one hour) one gram of low molecular weight iron dextran (INFeD) for the treatment of iron deficient anemia.
The American journal of medicine, 2017-12
Results of the First American Prospective Study of Intravenous Iron in Oral Iron-Intolerant Iron-Deficient Gravidas.
American journal of hematology, 2018-05
Comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia: A randomized trial.
Am J Hematol, 2020 Jun 29
A 6 month extension trial evaluating safety and efficacy of ferric derisomaltose in patients with iron deficiency anemia: The FERWON-EXT trial.
Am J Hematol, 2019 Sep
A prospective, multi-center, randomized comparison of iron isomaltoside 1000 versus iron sucrose in patients with iron deficiency anemia; the FERWON-IDA trial.
Am J Hematol, 2019 Sep
Single total dose infusion of ferumoxytol (1020 mg in 30 minutes) is an improved method of administration of intravenous iron.
Am J Hematol, 2018 Jun
Iron isomaltoside is superior to iron sucrose in increasing hemoglobin in gynecological patients with iron deficiency anemia.
JAMA,
Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials.
N Engl J Med,
Sickle Cell Disease.
Blood, 2017 Jan 19
How I treat cryoglobulinemia.
The journal of allergy and clinical immunology. In practice, 2017
Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.
American journal of hematology, 2008-08
Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.
Blood, 2010-07-22
How I treat hemochromatosis.
Am J Gastroenterol,
ACG Clinical Guideline: Hereditary Hemochromatosis.
Rheumatol Int, 2019 Apr 30
Indications for bone marrow examinations in rheumatology.
Clin Exp Rheumatol, 2012 Sep 25
Indications for bone marrow examination in autoimmune disorders with concurrent haematologic alterations.
Wien Klin Wochenschr,
[Rationale for bone marrow examination in patients with inflammatory rheumatic diseases].
Leukemia, 2009-05
The complete evaluation of erythrocytosis: congenital and acquired.
J Rheumatol, 2006 Jul 01
Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares.
Semin Arthritis Rheum,
Treatment of severe neutropenia due to Felty's syndrome or systemic lupus erythematosus with granulocyte colony-stimulating factor.
Blood, 2020 Sep 10
Anticoagulant therapy for splanchnic vein thrombosis: A systematic review and meta-analysis.
Blood Adv,
American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer.
Journal of thrombosis and haemostasis : JTH, 2013-04-10
Recommendations for the Standardization of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH.
J Thromb Haemost, 2009 Aug 19
Reducing intra-individual variation in platelet aggregation: implications for platelet function testing.
Clin Appl Thromb Hemost, 2018 Jun 19
Platelet Aggregation in Healthy Participants is Not Affected by Smoking, Drinking Coffee, Consuming a High-Fat Meal, or Performing Physical Exercise.
Blood, 2015 Sep 17
How I treat posttransplant lymphoproliferative disorders.
American journal of hematology, 2016-01
How we diagnose and treat iron deficiency anemia.
PLoS One, 2021 Apr 08
Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study.
Ann Intern Med,
The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis.
Seminars in hematology, 2013-07
Evaluation and management of patients with isolated neutropenia.
Am J Hematol, 2021 Jun 29
BNT162b2 COVID-19 vaccine is significantly less effective in patients with hematologic malignancies.
Blood, 2016-07-14
How I treat patients with inherited bleeding disorders who need anticoagulant therapy.
Blood, 2016 Sep 26
New concepts for anticoagulant therapy in persons with hemophilia.
JCO Oncol Pract, 2020 Aug 21
Changes in Intravenous Immunoglobulin Usage for Hypogammaglobulinemia After Implementation of a Stewardship Program.
Expert Rev Hematol, 2019 Jul 05
High-dose intravenous immunoglobulin for the treatment and prevention of heparin-induced thrombocytopenia: a review.
J Thromb Thrombolysis,
Comparative effectiveness and safety of direct oral anticoagulants compared to warfarin in morbidly obese patients with acute venous thromboembolism: systematic review and a meta-analysis.
Lancet Haematol,
Management of anticoagulant-refractory thrombotic antiphospholipid syndrome.
Leukemia, 2021 May 19
Direct oral anticoagulants for myeloproliferative neoplasms: results from an international study on 442 patients.
Circulation, 2012-09-25
Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates.
BMJ, 2021 Jun 09
Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial.
J Am Heart Assoc, 2020 Nov 23
Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study.
Am J Hematol,
Protein S abnormalities: a diagnostic nightmare.
Cancer Cell, 2020 Oct 08
Open Notes in Oncology: Patient versus Oncology Clinician Views.
J Gen Intern Med, 2021 Feb 02
Words Matter: What Do Patients Find Judgmental or Offensive in Outpatient Notes?
JAMA Netw Open, 2020 Jun 01
Frequency and Types of Patient-Reported Errors in Electronic Health Record Ambulatory Care Notes.
Practical radiation oncology, 2019-03
Impact of Open Access to Physician Notes on Radiation Oncology Patients: Results from an Exploratory Survey.
Blood Adv, 2020 Jan 28
American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.
Blood, 2019 Apr 25
Transfusion-related red blood cell alloantibodies: induction and consequences.
Circulation, 2022 Nov 06
A Randomized Controlled Trial Comparing Apixaban With the Vitamin K Antagonist Phenprocoumon in Patients on Chronic Hemodialysis: The AXADIA-AFNET 8 Study.
Circulation, 2022 Nov 06
Apixaban for Patients With Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial.
Lupus, 2021 May 27
16th International congress on antiphospholipid antibodies task force report on clinical manifestations of antiphospholipid syndrome.
Cancer causes & control : CCC, 2010-03
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Atherosclerosis, 2001-06
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The American journal of clinical nutrition, 2008-10
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Circulation. Cardiovascular genetics, 2008-12
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012-01
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Human genetics, 2012-05
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.
PeerJ, 2013
Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.
Nature, 2016-08-18
Analysis of protein-coding genetic variation in 60,706 humans.
Am J Hum Genet, 1998 May
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Am J Reprod Immunol, 2011 Jan 18
Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss.
Am J Reprod Immunol, 2012 Aug 06
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome.
BMC Cancer, 2008 Nov 07
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
BMJ Case Rep, 2012 Nov 15
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation.
BMJ Case Rep, 2013 Jun 13
Bilateral consecutive optic neuropathy in a patient with thrombophilia.
Mol Biol Rep, 2010 Jun 08
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk.
Mol Biol Rep, 2010 Nov 16
Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases.
Nat Genet, 2008 Jul
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Proc Natl Acad Sci U S A, 2001 Mar 13
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Mol Biol Rep, 2018 Mar 29
CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children.
Transfus Apher Sci, 2014 Jan 08
Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vein occlusion in Tunisian patients.
J Matern Fetal Neonatal Med, 2015 Jul 02
Thrombophilic genes alterations as risk factor for recurrent pregnancy loss.
Clin Neurol Neurosurg, 2013 Mar 21
Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.
J Hum Genet, 2006 Feb 18
MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers.
N Engl J Med,
Monoclonal Gammopathy of Renal Significance.
Am J Med,
Systemic lupus erythematosus and myelofibrosis.
Arthritis and rheumatism, 2007-07
Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals.
Stroke, 2014-07
Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
Cochrane Database Syst Rev, 2020 Oct 12
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
Archives of internal medicine, 1997-10-13
A retrospective review of 61 patients with antiphospholipid syndrome. Analysis of factors influencing recurrent thrombosis.
Lupus, 2011-02
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies.
Annals of the rheumatic diseases, 2019-10
EULAR recommendations for the management of antiphospholipid syndrome in adults.
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Diagnosis and Management of the Antiphospholipid Syndrome.
Lupus,
16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends.
Stroke, 2021 May 24
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.
J Autoimmun, 2018 Feb 13
The treatment of anti-phospholipid syndrome: A comprehensive clinical approach.
Int J Med Sci, 2009 Dec 05
Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome.
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Telangiectasia macularis eruptiva perstans: a neglected type of mastocytosis with exclusively cutaneous involvement? A case series.
J Thromb Haemost, 2020 Nov 29
Trial of Rivaroxaban in AntiPhospholipid Syndrome (TRAPS): Two-year outcomes after the study closure.
Front Cardiovasc Med, 2021 Aug 03
Use of Direct Oral Anticoagulants in Patients With Antiphospholipid Syndrome: A Systematic Review and Comparison of the International Guidelines.
Clin Microbiol Infect, 2018 Feb 07
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).
Arthritis & rheumatology (Hoboken, N.J.), 2018-03
The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.
J Thromb Haemost, 2009 Mar 05
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus.
Blood, 2018 Dec 21
How I treat low von Willebrand factor levels.
Genetic epidemiology, 2016-09
Association Between Absolute Neutrophil Count and Variation at TCIRG1: The NHLBI Exome Sequencing Project.
American journal of hematology, 2019-03
Neutropenia in the age of genetic testing: Advances and challenges.
Blood, 2021 Jan 07
When non-Whiteness becomes a condition.
Blood, 2013-08-01
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Circulation, 2003 Jun 17
The epidemiology of venous thromboembolism.
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The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients.
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18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis.
Rheumatology (Oxford), 2022 Jul 22
PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis.
Int J Lab Hematol, 2021 Oct 05
A single-institution retrospective study of causes of prolonged prothrombin time and activated partial thromboplastin time in the outpatient setting.
The New England journal of medicine, 2018-02-15
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism.
N Engl J Med, 2020 Mar 29
Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer.
N Engl J Med, 2003 Jul 10
Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
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Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy.
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Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.
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Anemia of Inflammation.
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A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome.
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Coagulation factor V levels as a prognostic indicator in fulminant hepatic failure.
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Cerebral and Splanchnic Vein Thrombosis: Advances, Challenges, and Unanswered Questions.
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Clots in unusual places: lots of stress, limited data, critical decisions.
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Seminars in hematology, 2002-04
Chronic neutropenia associated with autoimmune disease.
Blood, 2002 Jan 01
Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B.
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Long-term outcomes of peripheral blood stem cell unrelated donors mobilized with filgrastim.
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Overall survival and risk of second malignancies with cancer chemotherapy and G-CSF support.
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Use of Colony-Stimulating Factors in Patients With Systemic Lupus Erythematosus.
J Thromb Haemost, 2021 Jul 14
Use of direct oral anticoagulants in patients with obesity for treatment and prevention of venous thromboembolism: Updated communication from the ISTH SSC Subcommittee on Control of Anticoagulation.
Blood, 2020 Mar 19
How I treat obese patients with oral anticoagulants.
The New England journal of medicine, 1994-03-17
High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell disease.
Haematologica, 2013-09
A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.
European journal of haematology, 2003-08
Danaparoid for heparin-induced thrombocytopenia: an analysis of treatment failures.
Blood, 2016 Apr 25
How I treat patients with a history of heparin-induced thrombocytopenia.
Mayo Clinic proceedings, 2021 May 02
Using Reticulocyte Hemoglobin Equivalent as a Marker for Iron Deficiency and Responsiveness to Iron Therapy.
American journal of obstetrics and gynecology, 2023 Jul 05
Reticulocyte hemoglobin trend in pregnancy.
Gastroenterology, 2019 Apr 12
AGA Clinical Practice Update: Coagulation in Cirrhosis.
Blood, 2014 Oct 15
How I treat splanchnic vein thrombosis.
Blood, 2022 Jun 23
Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond.
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Antiphospholipid syndrome.
Autoimmunity reviews, 2018 Apr 07
Antinuclear antibodies: Is the indirect immunofluorescence still the gold standard or should be replaced by solid phase assays?
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Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature.
British journal of haematology, 2024 Sep 02
Measurement of heparin, direct oral anti-coagulants and other non-coumarin anti-coagulants and their effects on haemostasis assays: A British Society for Haematology Guideline.
JAMA, 2023 Aug 8
Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial.
Blood, 2017 Jan 31
Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines.
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